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Improvement of white matter and functional connectivity abnormalities by repetitive transcranial magnetic stimulation in crossed aphasia in dextral
Lu, Haitao1; Wu, Haiyan2; Cheng, Hewei3; Wei, Dongjie3; Wang, Xiaoyan1; Fan, Yong3; Zhang, Hao1; Zhang, Tong1
2014
Source PublicationINTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
ISSN1940-5901
SubtypeArticle
Volume7Issue:10Pages:3659-3668
AbstractAs a special aphasia, the occurrence of crossed aphasia in dextral (CAD) is unusual. This study aims to improve the language ability by applying 1 Hz repetitive transcranial magnetic stimulation (rTMS). We studied multiple modality imaging of structural connectivity (diffusion tensor imaging), functional connectivity (resting fMRI), PET, and neurolinguistic analysis on a patient with CAD. Furthermore, we applied rTMS of 1 Hz for 40 times and observed the language function improvement. The results indicated that a significantly reduced structural and function connectivity was found in DTI and fMRI data compared with the control. The PET imaging showed hypo-metabolism in right hemisphere and left cerebellum. In conclusion, one of the mechanisms of CAD is that right hemisphere is the language dominance. Stimulating left Wernicke area could improve auditory comprehension, stimulating left Broca's area could enhance expression, and the results outlasted 6 months by 1 Hz rTMS balancing the excitability inter-hemisphere in CAD.
KeywordCrossed aphasia in dextral diffusion tensor imaging functional magnetic resonance imaging positron emission tomography repetitive transcranial magnetic stimulation
Indexed BySCI
Language英语
WOS IDWOS:000345121100073
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13448
Collection中国科学院行为科学重点实验室
Affiliation1.Capital Med Univ, Dept Neurorehabil, Sch Rehabil Med, China Rehabil Res Ctr, Beijing 100068, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Inst Automat, Ctr Brainnetome, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Lu, Haitao,Wu, Haiyan,Cheng, Hewei,et al. Improvement of white matter and functional connectivity abnormalities by repetitive transcranial magnetic stimulation in crossed aphasia in dextral[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2014,7(10):3659-3668.
APA Lu, Haitao.,Wu, Haiyan.,Cheng, Hewei.,Wei, Dongjie.,Wang, Xiaoyan.,...&Zhang, Tong.(2014).Improvement of white matter and functional connectivity abnormalities by repetitive transcranial magnetic stimulation in crossed aphasia in dextral.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,7(10),3659-3668.
MLA Lu, Haitao,et al."Improvement of white matter and functional connectivity abnormalities by repetitive transcranial magnetic stimulation in crossed aphasia in dextral".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 7.10(2014):3659-3668.
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