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Lesions of the posterior paraventricular nucleus of the thalamus attenuate fear expression
Li, Yonghui1; Dong, Xinwen1; Li, Sa2; Kirouac, Gilbert J.2,3
2014-03-20
Source PublicationFRONTIERS IN BEHAVIORAL NEUROSCIENCE
ISSN1662-5153
SubtypeArticle
Volume8Issue:0Pages:94
AbstractThe paraventricular nucleus of the thalamus (PVT) has generated interest because of its strong projections to areas of the brain associated with the regulation of emotional behaviors. The posterior aspect of the PVT (pPVT) is notable for its projection to the central nucleus of the amygdala which is essential for the expression of a conditioned fear response. The present study was done to determine if the pPVT is involved in the expression of fear by examining the effect of post conditioning lesions of the pPVT. Male rats were trained to bar press for food pellets on a variable ratio schedule. Fear conditioning was done using auditory tones (30 s) that co-terminate with footschocks (0.65 mA, 1.0 s). Rats were anesthetized 24 h later and small bilateral electrolytic lesions of the pPVT were made. Fear expression to the tone was assessed using suppression of bar-pressing and freezing after one week of recovery from the surgical procedure. Small bilateral lesions of the pPVT increased bar-pressing for food and decreased freezing during the presentation of the conditioned tone. Lesions of the pPVT had no effect on fear extinction, fear conditioning to a novel tone, or the motivation for food as assessed using a progressive ratio (PR) schedule. The results of the experiment support a role for the pPVT in fear expression. In contrast, the pPVT does not appear to be involved in fear learning or extinction nor does it appear to play a role in the motivation of rats to bar press for food.
Keywordparaventricular nucleus fear learning midline thalamus motivation
Indexed BySCI
Language英语
WOS IDWOS:000333084800001
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13451
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Manitoba, Fac Dent, Dept Oral Biol, Winnipeg, MB R3E 0W2, Canada
3.Univ Manitoba, Fac Med, Dept Psychiat, Winnipeg, MB R3E 0W2, Canada
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Li, Yonghui,Dong, Xinwen,Li, Sa,et al. Lesions of the posterior paraventricular nucleus of the thalamus attenuate fear expression[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2014,8(0):94.
APA Li, Yonghui,Dong, Xinwen,Li, Sa,&Kirouac, Gilbert J..(2014).Lesions of the posterior paraventricular nucleus of the thalamus attenuate fear expression.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,8(0),94.
MLA Li, Yonghui,et al."Lesions of the posterior paraventricular nucleus of the thalamus attenuate fear expression".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 8.0(2014):94.
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