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Lesions of the posterior paraventricular nucleus of the thalamus attenuate fear expression
Li, Yonghui1; Dong, Xinwen1; Li, Sa2; Kirouac, Gilbert J.2,3
2014-03-20
发表期刊FRONTIERS IN BEHAVIORAL NEUROSCIENCE
ISSN1662-5153
文章类型Article
卷号8期号:0页码:94
摘要The paraventricular nucleus of the thalamus (PVT) has generated interest because of its strong projections to areas of the brain associated with the regulation of emotional behaviors. The posterior aspect of the PVT (pPVT) is notable for its projection to the central nucleus of the amygdala which is essential for the expression of a conditioned fear response. The present study was done to determine if the pPVT is involved in the expression of fear by examining the effect of post conditioning lesions of the pPVT. Male rats were trained to bar press for food pellets on a variable ratio schedule. Fear conditioning was done using auditory tones (30 s) that co-terminate with footschocks (0.65 mA, 1.0 s). Rats were anesthetized 24 h later and small bilateral electrolytic lesions of the pPVT were made. Fear expression to the tone was assessed using suppression of bar-pressing and freezing after one week of recovery from the surgical procedure. Small bilateral lesions of the pPVT increased bar-pressing for food and decreased freezing during the presentation of the conditioned tone. Lesions of the pPVT had no effect on fear extinction, fear conditioning to a novel tone, or the motivation for food as assessed using a progressive ratio (PR) schedule. The results of the experiment support a role for the pPVT in fear expression. In contrast, the pPVT does not appear to be involved in fear learning or extinction nor does it appear to play a role in the motivation of rats to bar press for food.
关键词paraventricular nucleus fear learning midline thalamus motivation
收录类别SCI
语种英语
WOS记录号WOS:000333084800001
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13451
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Manitoba, Fac Dent, Dept Oral Biol, Winnipeg, MB R3E 0W2, Canada
3.Univ Manitoba, Fac Med, Dept Psychiat, Winnipeg, MB R3E 0W2, Canada
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Li, Yonghui,Dong, Xinwen,Li, Sa,et al. Lesions of the posterior paraventricular nucleus of the thalamus attenuate fear expression[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2014,8(0):94.
APA Li, Yonghui,Dong, Xinwen,Li, Sa,&Kirouac, Gilbert J..(2014).Lesions of the posterior paraventricular nucleus of the thalamus attenuate fear expression.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,8(0),94.
MLA Li, Yonghui,et al."Lesions of the posterior paraventricular nucleus of the thalamus attenuate fear expression".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 8.0(2014):94.
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