A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus

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	A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus
	Cai, D. -C.1,2,3,4; Fonteijn, H.2,3; Guadalupe, T.2; Zwiers, M.3,6,7; Wittfeld, K.8; Teumer, A.9; Hoogman, M.2,3,5,6,7; Arias-Vasquez, A.3,5,6,7; Yang, Y.1; Buitelaar, J.3,5,6,7; Fernandez, G.3,5,6,7; Brunner, H. G.3,5,6,7; van Bokhoven, H.3,5,6,7; Franke, B.3,5,6,7; Hegenscheid, K.10; Homuth, G.11; Fisher, S. E.2,3; Grabe, H. J.8,12; Francks, C.2,3; Hagoort, P.2,3
摘要	Heschl's gyrus (HG) is a core region of the auditory cortex whose morphology is highly variable across individuals. This variability has been linked to sound perception ability in both speech and music domains. Previous studies show that variations in morphological features of HG, such as cortical surface area and thickness, are heritable. To identify genetic variants that affect HG morphology, we conducted a genome-wide association scan (GWAS) meta-analysis in 3054 healthy individuals using HG surface area and thickness as quantitative traits. None of the single nucleotide polymorphisms (SNPs) showed association P values that would survive correction for multiple testing over the genome. The most significant association was found between right HG area and SNP rs72932726 close to gene DCBLD2 (3q12.1; P=2.77x10(-7)). This SNP was also associated with other regions involved in speech processing. The SNP rs333332 within gene KALRN (3q21.2; P=2.27x10(-6)) and rs143000161 near gene COBLL1 (2q24.3; P=2.40x10(-6)) were associated with the area and thickness of left HG, respectively. Both genes are involved in the development of the nervous system. The SNP rs7062395 close to the X-linked deafness gene POU3F4 was associated with right HG thickness (Xq21.1; P=2.38x10(-6)). This is the first molecular genetic analysis of variability in HG morphology.
关键词	Auditory Network Genetics Genome-wide Association Scan Heschl's Gyrus Language Network Magnetic Resonance Imaging Speech Processing Surface-based
	2014-09-01
语种	英语
发表期刊	GENES BRAIN AND BEHAVIOR
ISSN	1601-1848
卷号	13 期号:7 页码:675-685
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000342823600011
引用统计	被引频次：29[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/13454
专题	健康与遗传心理学研究室
作者单位	1.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 2.Radboud Univ Nijmegen, Max Planck Inst Psycholinguist, NL-6525 ED Nijmegen, Netherlands 3.Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, NL-6525 ED Nijmegen, Netherlands 4.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China 5.Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands 6.Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, NL-6525 ED Nijmegen, Netherlands 7.Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci, NL-6525 ED Nijmegen, Netherlands 8.German Ctr Neurodegenerat Dis DZNE, Greifswald, Germany 9.Univ Med Greifswald, Inst Community Med, Greifswald, Germany 10.Univ Med Greifswald, Inst Radiol, Greifswald, Germany 11.Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany 12.Univ Med Greifswald, HELIOS Hosp Stralsund, Dept Psychiat & Psychotherapy, Stralsund, Germany
第一作者单位	中国科学院心理研究所
推荐引用方式 GB/T 7714	Cai, D. -C.,Fonteijn, H.,Guadalupe, T.,et al. A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus[J]. GENES BRAIN AND BEHAVIOR,2014,13(7):675-685.
APA	Cai, D. -C..,Fonteijn, H..,Guadalupe, T..,Zwiers, M..,Wittfeld, K..,...&Hagoort, P..(2014).A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.GENES BRAIN AND BEHAVIOR,13(7),675-685.
MLA	Cai, D. -C.,et al."A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus".GENES BRAIN AND BEHAVIOR 13.7(2014):675-685.

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