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A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus
Cai, D. -C.1,2,3,4; Fonteijn, H.2,3; Guadalupe, T.2; Zwiers, M.3,6,7; Wittfeld, K.8; Teumer, A.9; Hoogman, M.2,3,5,6,7; Arias-Vasquez, A.3,5,6,7; Yang, Y.1; Buitelaar, J.3,5,6,7; Fernandez, G.3,5,6,7; Brunner, H. G.3,5,6,7; van Bokhoven, H.3,5,6,7; Franke, B.3,5,6,7; Hegenscheid, K.10; Homuth, G.11; Fisher, S. E.2,3; Grabe, H. J.8,12; Francks, C.2,3; Hagoort, P.2,3
2014-09-01
发表期刊GENES BRAIN AND BEHAVIOR
ISSN1601-1848
文章类型Article
卷号13期号:7页码:675-685
摘要Heschl's gyrus (HG) is a core region of the auditory cortex whose morphology is highly variable across individuals. This variability has been linked to sound perception ability in both speech and music domains. Previous studies show that variations in morphological features of HG, such as cortical surface area and thickness, are heritable. To identify genetic variants that affect HG morphology, we conducted a genome-wide association scan (GWAS) meta-analysis in 3054 healthy individuals using HG surface area and thickness as quantitative traits. None of the single nucleotide polymorphisms (SNPs) showed association P values that would survive correction for multiple testing over the genome. The most significant association was found between right HG area and SNP rs72932726 close to gene DCBLD2 (3q12.1; P=2.77x10(-7)). This SNP was also associated with other regions involved in speech processing. The SNP rs333332 within gene KALRN (3q21.2; P=2.27x10(-6)) and rs143000161 near gene COBLL1 (2q24.3; P=2.40x10(-6)) were associated with the area and thickness of left HG, respectively. Both genes are involved in the development of the nervous system. The SNP rs7062395 close to the X-linked deafness gene POU3F4 was associated with right HG thickness (Xq21.1; P=2.38x10(-6)). This is the first molecular genetic analysis of variability in HG morphology.
关键词Auditory Network Genetics Genome-wide Association Scan Heschl's Gyrus Language Network Magnetic Resonance Imaging Speech Processing Surface-based
收录类别SCI
语种英语
WOS记录号WOS:000342823600011
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13454
专题健康与遗传心理学研究室
作者单位1.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
2.Radboud Univ Nijmegen, Max Planck Inst Psycholinguist, NL-6525 ED Nijmegen, Netherlands
3.Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, NL-6525 ED Nijmegen, Netherlands
4.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
5.Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands
6.Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, NL-6525 ED Nijmegen, Netherlands
7.Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci, NL-6525 ED Nijmegen, Netherlands
8.German Ctr Neurodegenerat Dis DZNE, Greifswald, Germany
9.Univ Med Greifswald, Inst Community Med, Greifswald, Germany
10.Univ Med Greifswald, Inst Radiol, Greifswald, Germany
11.Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany
12.Univ Med Greifswald, HELIOS Hosp Stralsund, Dept Psychiat & Psychotherapy, Stralsund, Germany
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Cai, D. -C.,Fonteijn, H.,Guadalupe, T.,et al. A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus[J]. GENES BRAIN AND BEHAVIOR,2014,13(7):675-685.
APA Cai, D. -C..,Fonteijn, H..,Guadalupe, T..,Zwiers, M..,Wittfeld, K..,...&Hagoort, P..(2014).A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.GENES BRAIN AND BEHAVIOR,13(7),675-685.
MLA Cai, D. -C.,et al."A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus".GENES BRAIN AND BEHAVIOR 13.7(2014):675-685.
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