Inactivation of the prelimbic rather than infralimbic cortex impairs acquisition and expression of formalin-induced conditioned place avoidance

	Inactivation of the prelimbic rather than infralimbic cortex impairs acquisition and expression of formalin-induced conditioned place avoidance
	Jiang, Zhao-Cai1,2 ; Pan, Qi 3; Zheng, Chun 1,2,4; Deng, Xiao-Fei 1,2; Wang, Jin-Yan1 ; Luo, Fei1
摘要	Conditioned place avoidance (CPA) paradigm has been used to investigate the affective component of pain. Although the anterior cingulate cortex (ACC) has been demonstrated to play an important role in the affective aspect of pain, whether the other prefrontal subdivisions are involved in pain-related aversion is unknown. The present study investigated the role of the prelimbic cortex (PL) and infralimbic cortex (IL) in the acquisition and expression of formalin-induced CPA (F-CPA) in rats. GABA(A) receptor agonist muscimol was bilaterally microinjected into PL/IL before or after the formalin-paired training, to explore the effect of temporary inactivation of PL/IL on the acquisition and expression of F-CPA, respectively. The results showed that inactivation of PL rather than IL impaired the acquisition and expression of F-CPA. Moreover, the PL inactivation did not block the acquisition of LiCl-induced CPA, suggesting that PL may be specifically implicated in the pain-emotion related encoding. These results indicate that PL but not IL is involved in the aversive dimension of pain. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
关键词	Prefrontal cortex Conditioned place avoidance Acquisition Expression Pain emotion Rats
	2014-05-21
语种	英语
发表期刊	NEUROSCIENCE LETTERS
ISSN	0304-3940
卷号	569 期号:0 页码:89-93
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000336356100018
引用统计	被引频次：27[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/13455
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 3.Southern Med Univ, Zhujiang Hosp, Dept Neurosurg, Guangzhou 510282, Guangdong, Peoples R China 4.Southwest Univ Nationalities, Dept Psychol, Chengdu 610041, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Jiang, Zhao-Cai,Pan, Qi,Zheng, Chun,et al. Inactivation of the prelimbic rather than infralimbic cortex impairs acquisition and expression of formalin-induced conditioned place avoidance[J]. NEUROSCIENCE LETTERS,2014,569(0):89-93.
APA	Jiang, Zhao-Cai,Pan, Qi,Zheng, Chun,Deng, Xiao-Fei,Wang, Jin-Yan,&Luo, Fei.(2014).Inactivation of the prelimbic rather than infralimbic cortex impairs acquisition and expression of formalin-induced conditioned place avoidance.NEUROSCIENCE LETTERS,569(0),89-93.
MLA	Jiang, Zhao-Cai,et al."Inactivation of the prelimbic rather than infralimbic cortex impairs acquisition and expression of formalin-induced conditioned place avoidance".NEUROSCIENCE LETTERS 569.0(2014):89-93.

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