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Long-Term Temporal Imprecision of Information Coding in the Anterior Cingulate Cortex of Mice with Peripheral Inflammation or Nerve Injury
Li, Xiang-Yao1,2; Wang, Ning3; Wang, Yong-Jie1; Zuo, Zhen-Xing1; Koga, Kohei2; Luo, Fei3; Zhuo, Min1,2
2014-08-06
Source PublicationJOURNAL OF NEUROSCIENCE
ISSN0270-6474
SubtypeArticle
Volume34Issue:32Pages:10675-10687
AbstractTemporal properties of spike firing in the central nervous system (CNS) are critical for neuronal coding and the precision of information storage. Chronic pain has been reported to affect cognitive and emotional functions, in addition to trigger long-term plasticity in sensory synapses and behavioral sensitization. Less is known about the possible changes in temporal precision of cortical neurons in chronic pain conditions. In the present study, we investigated the temporal precision of action potential firing in the anterior cingulate cortex (ACC) by using both in vivo and in vitro electrophysiological approaches. We found that peripheral inflammation caused by complete Freund's adjuvant (CFA) increased the standard deviation (SD) of spikes latency (also called jitter) of similar to 51% of recorded neurons in the ACC of adult rats in vivo. Similar increases in jitter were found in ACC neurons using in vitro brain slices from adult mice with peripheral inflammation or nerve injury. Bath application of glutamate receptor antagonists CNQX and AP5 abolished the enhancement of jitter induced by CFA injection or nerve injury, suggesting that the increased jitter depends on the glutamatergic synaptic transmission. Activation of adenylyl cyclases (ACs) by bath application of forskolin increased jitter, whereas genetic deletion of AC1 abolished the change of jitter caused by CFA inflammation. Our study provides strong evidence for long-term changes of temporal precision of information coding in cortical neurons after peripheral injuries and explains neuronal mechanism for chronic pain caused cognitive and emotional impairment.
KeywordChronic Pain Cingulate Cortex Cortex Mice Synaptic Transmission Temporal Precision
Indexed BySCI
Language英语
WOS IDWOS:000341017300021
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13464
Collection中国科学院心理健康重点实验室
Affiliation1.Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Ctr Neuron & Dis, Xian 710054, Shaanxi, Peoples R China
2.Univ Toronto, Ctr Study Pain, Fac Med, Dept Physiol, Toronto, ON M5S 1A8, Canada
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Li, Xiang-Yao,Wang, Ning,Wang, Yong-Jie,et al. Long-Term Temporal Imprecision of Information Coding in the Anterior Cingulate Cortex of Mice with Peripheral Inflammation or Nerve Injury[J]. JOURNAL OF NEUROSCIENCE,2014,34(32):10675-10687.
APA Li, Xiang-Yao.,Wang, Ning.,Wang, Yong-Jie.,Zuo, Zhen-Xing.,Koga, Kohei.,...&Zhuo, Min.(2014).Long-Term Temporal Imprecision of Information Coding in the Anterior Cingulate Cortex of Mice with Peripheral Inflammation or Nerve Injury.JOURNAL OF NEUROSCIENCE,34(32),10675-10687.
MLA Li, Xiang-Yao,et al."Long-Term Temporal Imprecision of Information Coding in the Anterior Cingulate Cortex of Mice with Peripheral Inflammation or Nerve Injury".JOURNAL OF NEUROSCIENCE 34.32(2014):10675-10687.
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