Institutional Repository of Key Laboratory of Behavioral Science, CAS
| Altered brain functional connectivity in hemodialysis patients with end-stage renal disease: a resting-state functionalMR imaging study | |
Zheng, Gang1,2 ; Wen, Jiqiu3; Zhang, Liping4; Zhong, Jianhui5; Liang, Xue1; Ke, Wenwei4; Kong, Xiang1; Zhao, Tiezhu2; He, Yong6; Zuo, Xinian7; Luo, Song1; Zhang, Long Jiang1; Lu, Guang Ming1
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| 摘要 | The changes of whole brain functional connectivity in hemodialysis (HD) patients with end-stage renal disease (ESRD) are still unclear, which may be associated with multiple factors, such as elevated neurotoxins, anemia, and side effects of hemodialysis. Resting-state functional magnetic resonance imaging (rs-fMRI) data of 71 patients (43 males, 28 females; mean age, 33.4 +/- 9.4 years) and 43 age- and gender-matched healthy volunteers (29 males, 14 females; mean age, 30.6 +/- 8.8 years) were acquired. Neuropsychological tests including number connection test type A (NCT-A), digit symbol test (DST), line-tracing test (LTT), serial-dotting test (SDT), self-rating depression scale (SDS) and self-rating anxiety scale (SAS) were used to evaluate cognitive and psychiatric conditions in all subjects. Blood biochemistry tests including serum creatinine levels, blood urea, hematocrit, and Ca2+ level were taken in HD patients. Forty-two connections significantly different between HD patients with ESRD and controls were found (all P < 0.05, Bonferroni corrected) and identified as connectivities of interests (COIs), among which 39 connections (92.9 %) were markedly decreased in patients. Of the 39 weaker connections, 24 were related to the frontal lobe regions. Widespread weakening of cortical and subcortical network connectivity in ESRD patients was more directly related with neuropsychological impairments and anemia rather than serum creatinine level, blood urea and dialysis duration. In particular, impairments in the medial prefrontal lobe could play an important role in mediating psychological dysfunctions. |
| 关键词 | End-stage Renal Disease Hemodialysis Resting-state Fmri Functional Connectivity |
| 2014-09-01 | |
| 语种 | 英语 |
| 发表期刊 | METABOLIC BRAIN DISEASE
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| ISSN | 0885-7490 |
| 卷号 | 29期号:3页码:777-786 |
| 期刊论文类型 | Article |
| 收录类别 | SCI |
| WOS记录号 | WOS:000340492600025 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/13470 |
| 专题 | 中国科学院行为科学重点实验室 |
| 作者单位 | 1.Nanjing Univ, Sch Med, Dept Med Imaging, Jinling Hosp, Nanjing 210002, Jiangsu, Peoples R China 2.Nanjing Univ Aeronaut & Astronaut, Coll Civil Aviat, Nanjing 210016, Jiangsu, Peoples R China 3.Nanjing Univ, Res Inst Nephrol, Jinling Hosp, Sch Med, Nanjing 210002, Jiangsu, Peoples R China 4.Nanjing Univ Aeronaut & Astronaut, Coll Nat Sci, Nanjing 210016, Jiangsu, Peoples R China 5.Zhejiang Univ, Dept Biomed Engn, Hangzhou 310027, Zhejiang, Peoples R China 6.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 7.Chinese Acad Sci, Key Lab Behav Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Gang,Wen, Jiqiu,Zhang, Liping,et al. Altered brain functional connectivity in hemodialysis patients with end-stage renal disease: a resting-state functionalMR imaging study[J]. METABOLIC BRAIN DISEASE,2014,29(3):777-786. |
| APA | Zheng, Gang.,Wen, Jiqiu.,Zhang, Liping.,Zhong, Jianhui.,Liang, Xue.,...&Lu, Guang Ming.(2014).Altered brain functional connectivity in hemodialysis patients with end-stage renal disease: a resting-state functionalMR imaging study.METABOLIC BRAIN DISEASE,29(3),777-786. |
| MLA | Zheng, Gang,et al."Altered brain functional connectivity in hemodialysis patients with end-stage renal disease: a resting-state functionalMR imaging study".METABOLIC BRAIN DISEASE 29.3(2014):777-786. |
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| WOS_000340492600025.（4009KB） | 期刊论文 | 出版稿 | 暂不开放 | CC BY-NC-SA | 请求全文 | |
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