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The self and its resting state in consciousness: An investigation of the vegetative state
Huang, Zirui1,2; Dai, Rui3; Wu, Xuehai4; Yang, Zhi5; Liu, Dongqiang2; Hu, Jin4; Gao, Liang4; Tang, Weijun6; Mao, Ying4; Jin, Yi4; Wu, Xing4; Liu, Bin6; Zhang, Yao7; Lu, Lu7; Laureys, Steven8; Weng, Xuchu2; Northoff, Georg1,2
AbstractRecent studies have demonstrated resting-state abnormalities in midline regions in vegetative state/unresponsive wakefulness syndrome and minimally conscious state patients. However, the functional implications of these resting-state abnormalities remain unclear. Recent findings in healthy subjects have revealed a close overlap between the neural substrate of self-referential processing and the resting-state activity in cortical midline regions. As such, we investigated task-related neural activity during active self-referential processing and various measures of resting-state activity in 11 patients with disorders of consciousness (DOC) and 12 healthy control subjects. Overall, the results revealed that DOC patients exhibited task-specific signal changes in anterior and posterior midline regions, including the perigenual anterior cingulate cortex (PACC) and posterior cingulate cortex (PCC). However, the degree of signal change was significantly lower in DOC patients compared with that in healthy subjects. Moreover, reduced signal differentiation in the PACC predicted the degree of consciousness in DOC patients. Importantly, the same midline regions (PACC and PCC) in DOC patients also exhibited severe abnormalities in the measures of resting-state activity, that is functional connectivity and the amplitude of low-frequency fluctuations. Taken together, our results provide the first evidence of neural abnormalities in both the self-referential processing and the resting state in midline regions in DOC patients. This novel finding has important implications for clinical utility and general understanding of the relationship between the self, the resting state, and consciousness. Hum Brain Mapp 35:1997-2008, 2014. (c) 2013 Wiley Periodicals, Inc.
Keywordcoma low-frequency fluctuations fMRI resting state minimally conscious state functional connectivity vegetative state self-referential processing cortical midline regions disorders of consciousness
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Affiliation1.Univ Ottawa, Mental Hlth Res Inst, Ottawa, ON K1Z 7K4, Canada
2.Hangzhou Normal Univ, Zhejiang Key Lab Res Assessment Cognit Impairment, Hangzhou, Zhejiang, Peoples R China
3.S China Normal Univ, Sch Life Sci, Guangzhou, Guangdong, Peoples R China
4.Fudan Univ, Huashan Hosp, Dept Neurosurg, Shanghai 200433, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
6.Fudan Univ, Dept Radiol, Huashan Hosp, Shanghai 200433, Peoples R China
7.Huajia Hosp, Shanghai, Peoples R China
8.Univ Liege, Cyclotron Res Ctr, Coma Sci Grp, Liege, Belgium
Recommended Citation
GB/T 7714
Huang, Zirui,Dai, Rui,Wu, Xuehai,et al. The self and its resting state in consciousness: An investigation of the vegetative state[J]. HUMAN BRAIN MAPPING,2014,35(5):1997-2008.
APA Huang, Zirui.,Dai, Rui.,Wu, Xuehai.,Yang, Zhi.,Liu, Dongqiang.,...&Northoff, Georg.(2014).The self and its resting state in consciousness: An investigation of the vegetative state.HUMAN BRAIN MAPPING,35(5),1997-2008.
MLA Huang, Zirui,et al."The self and its resting state in consciousness: An investigation of the vegetative state".HUMAN BRAIN MAPPING 35.5(2014):1997-2008.
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