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Common Variants on Xq28 Conferring Risk of Schizophrenia in Han Chinese
Wong, Emily H. M.1; So, Hon-Cheong1; Li, Miaoxin1,2; Wang, Quang3,4; Butler, Amy W.1,5; Paul, Basil1; Wu, Hei-Man1; Hui, Tomy C. K.1; Choi, Siu-Chung1; So, Man-Ting6; Garcia-Barcelo, Maria-Merce2,6; McAlonan, Grainne M.7; Chen, Eric Y. H.1; Cheung, Eric F. C.8; Chan, Raymond C. K.9; Purcell, Shaun M.10; Cherny, Stacey S.1,2,11; Chen, Ronald R. L.1; Li, Tao3,4; Sham, Pak-Chung1,2,11
2014-07-01
Source PublicationSCHIZOPHRENIA BULLETIN
ISSN0586-7614
SubtypeArticle
Volume40Issue:4Pages:777-786
AbstractSchizophrenia is a highly heritable, severe psychiatric disorder affecting approximately 1% of the world population. A substantial portion of heritability is still unexplained and the pathophysiology of schizophrenia remains to be elucidated. To identify more schizophrenia susceptibility loci, we performed a genome-wide association study (GWAS) on 498 patients with schizophrenia and 2025 controls from the Han Chinese population, and a follow-up study on 1027 cases and 1005 controls. In the follow-up study, we included 384 single nucleotide polymorphisms (SNPs) which were selected from the top hits in our GWAS (130 SNPs) and from previously implicated loci for schizophrenia based on the SZGene database, NHGRI GWAS Catalog, copy number variation studies, GWAS meta-analysis results from the international Psychiatric Genomics Consortium (PGC) and candidate genes from plausible biological pathways (254 SNPs).
KeywordSchizophrenia Genome-wide Association Study Han Chinese Mecp2 Arhgap4 Renbp
Indexed BySSCI
Language英语
WOS IDWOS:000338130300010
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13473
Collection健康与遗传心理学研究室
Affiliation1.Univ Hong Kong, Dept Psychiat, Pokfulam, Hong Kong, Peoples R China
2.Univ Hong Kong, Ctr Genom Sci, Pokfulam, Hong Kong, Peoples R China
3.Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu 610064, Sichuan, Peoples R China
4.Sichuan Univ, West China Hosp, Psychiat Lab, Chengdu 610064, Sichuan, Peoples R China
5.Kings Coll London, Inst Psychiat, MRC Social Genet & Dev Psychiat Ctr, London WC2R 2LS, England
6.Univ Hong Kong, Dept Surg, Pokfulam, Hong Kong, Peoples R China
7.Kings Coll London, Inst Psychiat, Dept Forens & Neurodev Sci, London WC2R 2LS, England
8.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
9.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
10.Mt Sinai Sch Med, Div Psychiat Genom, New York, NY USA
11.Univ Hong Kong, State Key Lab Brain & Cognit Sci, Pokfulam, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Wong, Emily H. M.,So, Hon-Cheong,Li, Miaoxin,et al. Common Variants on Xq28 Conferring Risk of Schizophrenia in Han Chinese[J]. SCHIZOPHRENIA BULLETIN,2014,40(4):777-786.
APA Wong, Emily H. M..,So, Hon-Cheong.,Li, Miaoxin.,Wang, Quang.,Butler, Amy W..,...&Sham, Pak-Chung.(2014).Common Variants on Xq28 Conferring Risk of Schizophrenia in Han Chinese.SCHIZOPHRENIA BULLETIN,40(4),777-786.
MLA Wong, Emily H. M.,et al."Common Variants on Xq28 Conferring Risk of Schizophrenia in Han Chinese".SCHIZOPHRENIA BULLETIN 40.4(2014):777-786.
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