Altered local activity and functional connectivity of the anterior cingulate cortex in elderly individuals with subthreshold depression

	Altered local activity and functional connectivity of the anterior cingulate cortex in elderly individuals with subthreshold depression
	Li, Rui1,2,3 ; Ma, Zhenling1,4 ; Yu, Jing1,5 ; He, Yong 6; Li, Juan1,2,3
摘要	The anterior cingulate cortex (ACC) is recognized as a key structure in the pathogenesis of depression. This study aimed to investigate the resting-state regional activity and functional connectivity of the ACC in a community sample of elderly individuals with subthreshold depression (StD). We employed resting-state functional magnetic resonance imaging to acquire data from 19 elderly subjects with StD and 18 normal controls. We used a regional amplitude of low-frequency fluctuation (ALFF) analysis and a correlation-based functional connectivity (FC) approach to explore changes in local activity and remote connectivity of the ACC in StD. Compared to controls, the StD group demonstrated increased ALFF in the anterior portion of the dorsal ACC (adACC). The adACC also displayed increased PC with the dorsolateral prefrontal cortex and supplementary motor area and decreased PC with several subcortical regions. The FC levels of the adACC displayed a trending correlation with self-reported depressive symptoms. This study is the first to reveal the ACC changes in resting-state activity and connectivity in the elderly with StD, suggesting that altered ALFF/FC of the adACC is an important feature of StD. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
关键词	fMRI Resting state Anterior cingulate Depression
	2014-04-30
语种	英语
发表期刊	PSYCHIATRY RESEARCH-NEUROIMAGING
ISSN	0925-4927
卷号	222 期号:1-2 页码:29-36
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000334739500004
引用统计	被引频次：18[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/13474
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Ctr Aging Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China 3.Beijing Normal Univ, Res Ctr Emot Regulat, Beijing 100875, Peoples R China 4.Peking Union Med Coll, Sch Nursing, Beijing 100144, Peoples R China 5.Southwest Univ, Sch Psychol, Chongqing 400715, Peoples R China 6.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
第一作者单位	中国科学院心理健康重点实验室; 管理支撑系统
推荐引用方式 GB/T 7714	Li, Rui,Ma, Zhenling,Yu, Jing,et al. Altered local activity and functional connectivity of the anterior cingulate cortex in elderly individuals with subthreshold depression[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2014,222(1-2):29-36.
APA	Li, Rui,Ma, Zhenling,Yu, Jing,He, Yong,&Li, Juan.(2014).Altered local activity and functional connectivity of the anterior cingulate cortex in elderly individuals with subthreshold depression.PSYCHIATRY RESEARCH-NEUROIMAGING,222(1-2),29-36.
MLA	Li, Rui,et al."Altered local activity and functional connectivity of the anterior cingulate cortex in elderly individuals with subthreshold depression".PSYCHIATRY RESEARCH-NEUROIMAGING 222.1-2(2014):29-36.

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