Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia

	Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia
	Jiang, Zhao-Cai1,2 ; Qi, Wei-Jing1,3 ; Wang, Jin-Yan1 ; Luo, Fei1
摘要	Previous studies have shown that depressed patients as well as animal models of depression exhibit decreased sensitivity to evoked pain stimuli, and serotonin is indicated to be involved in depression-induced hypoalgesia. The purpose of this study was to investigate the potential role of 5-HT1A receptor in the depression-induced hypoalgesia. Acute or chronic administration of 5-HT1A receptor agonist, 8-OH-DPAT, was performed in olfactory bulbectomy (OB) and sham-operated rats. The depression-like behavior and pain thresholds were measured using open-field test and radiant heat thermal pain test, respectively. We found that acute administration of 8-OH-DPAT increased locomotor activity and pain thresholds in the sham rats but had no effect on the OB rats. In contrast, chronic administration of 8-OH-DPAT reduced locomotor activity and pain thresholds and restored them to normal level. Increased pain thresholds were also observed in the sham rats after the chronic administration. These results demonstrated that chronic administration of 8-OH-DPAT reversed the depression-induced decrease in pain sensitivity in rats, suggesting that 5-HT1A receptor may play a role in the depression-associated hypoalgesia.
	2014
语种	英语
发表期刊	SCIENTIFIC WORLD JOURNAL
ISSN	1537-744X
卷号	2014 期号:0 页码:405736
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000330704000001
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/13475
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 3.Chinese Acad Chinese Med Sci, Guanganmen Hosp, Dept Psychol, Beijing 100035, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Jiang, Zhao-Cai,Qi, Wei-Jing,Wang, Jin-Yan,et al. Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia[J]. SCIENTIFIC WORLD JOURNAL,2014,2014(0):405736.
APA	Jiang, Zhao-Cai,Qi, Wei-Jing,Wang, Jin-Yan,&Luo, Fei.(2014).Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia.SCIENTIFIC WORLD JOURNAL,2014(0),405736.
MLA	Jiang, Zhao-Cai,et al."Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia".SCIENTIFIC WORLD JOURNAL 2014.0(2014):405736.

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