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Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia
Jiang, Zhao-Cai1,2; Qi, Wei-Jing1,3; Wang, Jin-Yan1; Luo, Fei1
2014
发表期刊SCIENTIFIC WORLD JOURNAL
ISSN1537-744X
文章类型Article
卷号2014期号:0页码:405736
摘要Previous studies have shown that depressed patients as well as animal models of depression exhibit decreased sensitivity to evoked pain stimuli, and serotonin is indicated to be involved in depression-induced hypoalgesia. The purpose of this study was to investigate the potential role of 5-HT1A receptor in the depression-induced hypoalgesia. Acute or chronic administration of 5-HT1A receptor agonist, 8-OH-DPAT, was performed in olfactory bulbectomy (OB) and sham-operated rats. The depression-like behavior and pain thresholds were measured using open-field test and radiant heat thermal pain test, respectively. We found that acute administration of 8-OH-DPAT increased locomotor activity and pain thresholds in the sham rats but had no effect on the OB rats. In contrast, chronic administration of 8-OH-DPAT reduced locomotor activity and pain thresholds and restored them to normal level. Increased pain thresholds were also observed in the sham rats after the chronic administration. These results demonstrated that chronic administration of 8-OH-DPAT reversed the depression-induced decrease in pain sensitivity in rats, suggesting that 5-HT1A receptor may play a role in the depression-associated hypoalgesia.
收录类别SCI
语种英语
WOS记录号WOS:000330704000001
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13475
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
3.Chinese Acad Chinese Med Sci, Guanganmen Hosp, Dept Psychol, Beijing 100035, Peoples R China
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Jiang, Zhao-Cai,Qi, Wei-Jing,Wang, Jin-Yan,et al. Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia[J]. SCIENTIFIC WORLD JOURNAL,2014,2014(0):405736.
APA Jiang, Zhao-Cai,Qi, Wei-Jing,Wang, Jin-Yan,&Luo, Fei.(2014).Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia.SCIENTIFIC WORLD JOURNAL,2014(0),405736.
MLA Jiang, Zhao-Cai,et al."Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia".SCIENTIFIC WORLD JOURNAL 2014.0(2014):405736.
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