Institutional Repository of Key Laboratory of Behavioral Science, CAS
| Disrupted thalamo-cortical connectivity in schizophrenia: A morphometric correlation analysis | |
Zhang, Yuanchao1,2; Su, Tung-Ping3; Liu, Bing2; Zhou, Yuan4,8 ; Chou, Kun-Hsien5; Lo, Chun-Yi5; Hung, Chia-Chun5,6,7; Chen, Wei-Ling7; Jiang, Tianzi1,2; Lin, Ching-Po5,6
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| 摘要 | Increasing studies have implicated the thalamus in schizophrenia, supporting the view that this structure has an important role in this disorder. Given that extensive reciprocal connections exist between the thalamus and the cerebral cortex, it is believed that disruptions of the thalamo-cortical connections may underlie the multiplicity of schizophrenic symptoms. Therefore, assessing the relationship between the thalamus and the neocortex may provide new insights into the pathophysiology of schizophrenia. We analyzed magnetic resonance images from a sample of 101 schizophrenic patients and 101 healthy controls. By assessing the correlation between the thalamic volume and cortical thickness at each vertex on the cortical surface, a thalamo-cortical network was obtained for each group. We compared the patterns of thalamo-cortical connectivity between the two groups. Compared with healthy controls, less distributed cortical regions were identified in the thalamocortical network in patients with schizophrenia. Vertex-wise comparison revealed decreased thalamo-cortical connectivity in bilateral inferior frontal gyrus, the left superior temporal gyrus and the right parieto-occipital region in schizophrenia. The observed disruptions in thalamo-cortical connectivity might be the substrate underlying the wide range of schizophrenic symptoms and provide further evidence to support the notion of schizophrenia as a disorder of brain dysconnectivity. (C) 2014 Elsevier B. V. All rights reserved. |
| 关键词 | Schizophrenia Magnetic resonance imaging Thalamus Thalamo-cortical network Dysconnectivity |
| 2014-03-01 | |
| 语种 | 英语 |
| 发表期刊 | SCHIZOPHRENIA RESEARCH
 |
| ISSN | 0920-9964 |
| 卷号 | 153期号:1-3页码:129-135 |
| 期刊论文类型 | Article |
| 收录类别 | SSCI |
| WOS记录号 | WOS:000333052800020 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/13477 |
| 专题 | 中国科学院行为科学重点实验室 |
| 作者单位 | 1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Chengdu 610054, Peoples R China 2.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China 3.Natl Yang Ming Univ, Dept Psychiat, Coll Med, Taipei 11221, Taiwan 4.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China 5.Natl Yang Ming Univ, Brain Connect Lab, Inst Neurosci, Taipei 11221, Taiwan 6.Natl Yang Ming Univ, Inst Brain Sci, Taipei 11221, Taiwan 7.Taichung Vet Gen Hosp, Dept Psychiat, Taichung 407, Taiwan 8.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yuanchao,Su, Tung-Ping,Liu, Bing,et al. Disrupted thalamo-cortical connectivity in schizophrenia: A morphometric correlation analysis[J]. SCHIZOPHRENIA RESEARCH,2014,153(1-3):129-135. |
| APA | Zhang, Yuanchao.,Su, Tung-Ping.,Liu, Bing.,Zhou, Yuan.,Chou, Kun-Hsien.,...&Lin, Ching-Po.(2014).Disrupted thalamo-cortical connectivity in schizophrenia: A morphometric correlation analysis.SCHIZOPHRENIA RESEARCH,153(1-3),129-135. |
| MLA | Zhang, Yuanchao,et al."Disrupted thalamo-cortical connectivity in schizophrenia: A morphometric correlation analysis".SCHIZOPHRENIA RESEARCH 153.1-3(2014):129-135. |
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| WOS_000333052800020.（728KB） | 期刊论文 | 出版稿 | 暂不开放 | CC BY-NC-SA | 请求全文 | |
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