Multimodal intervention in older adults improves resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe

	Multimodal intervention in older adults improves resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe
	Li, Rui1,2 ; Zhu, Xinyi1 ; Yin, Shufei 1; Niu, Yanan1,2 ; Zheng, Zhiwei1 ; Huang, Xin1 ; Wang, Baoxi 1; Li, Juan1,2
摘要	The prefrontal cortex and medial temporal lobe are particularly vulnerable to the effects of aging. The disconnection between them is suggested to be an important cause of cognitive decline in normal aging. Here, using multimodal intervention training, we investigated the functional plasticity in resting-state connectivity of these two regions in older adults. The multimodal intervention, comprised of cognitive training, Tai Chi exercise, and group counseling, was conducted to explore the regional connectivity changes in the default mode network, as well as changes in prefrontal-based voxel-wise connectivity in the whole brain. Results showed that the intervention selectively affected resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe. Moreover, the strength of resting-state functional connectivity between these regions correlated with individual cognitive performance. Our results suggest that multimodal intervention could postpone the effects of aging and improve the function of the regions that are most heavily influenced by aging, as well as play an important role in preserving the brain and cognition during old age.
关键词	intervention plasticity aging fMRI functional connectivity
	2014-03-10
语种	英语
发表期刊	FRONTIERS IN AGING NEUROSCIENCE
ISSN	1663-4365
卷号	6 期号:0 页码:39
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000332607600001
引用统计	被引频次：89[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/13479
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Ctr Aging Psychol, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
第一作者单位	管理支撑系统
推荐引用方式 GB/T 7714	Li, Rui,Zhu, Xinyi,Yin, Shufei,et al. Multimodal intervention in older adults improves resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe[J]. FRONTIERS IN AGING NEUROSCIENCE,2014,6(0):39.
APA	Li, Rui.,Zhu, Xinyi.,Yin, Shufei.,Niu, Yanan.,Zheng, Zhiwei.,...&Li, Juan.(2014).Multimodal intervention in older adults improves resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe.FRONTIERS IN AGING NEUROSCIENCE,6(0),39.
MLA	Li, Rui,et al."Multimodal intervention in older adults improves resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe".FRONTIERS IN AGING NEUROSCIENCE 6.0(2014):39.

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