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Multimodal intervention in older adults improves resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe
Li, Rui1,2; Zhu, Xinyi1; Yin, Shufei1; Niu, Yanan1,2; Zheng, Zhiwei1; Huang, Xin1; Wang, Baoxi1; Li, Juan1,2
2014-03-10
发表期刊FRONTIERS IN AGING NEUROSCIENCE
ISSN1663-4365
文章类型Article
卷号6期号:0页码:39
摘要The prefrontal cortex and medial temporal lobe are particularly vulnerable to the effects of aging. The disconnection between them is suggested to be an important cause of cognitive decline in normal aging. Here, using multimodal intervention training, we investigated the functional plasticity in resting-state connectivity of these two regions in older adults. The multimodal intervention, comprised of cognitive training, Tai Chi exercise, and group counseling, was conducted to explore the regional connectivity changes in the default mode network, as well as changes in prefrontal-based voxel-wise connectivity in the whole brain. Results showed that the intervention selectively affected resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe. Moreover, the strength of resting-state functional connectivity between these regions correlated with individual cognitive performance. Our results suggest that multimodal intervention could postpone the effects of aging and improve the function of the regions that are most heavily influenced by aging, as well as play an important role in preserving the brain and cognition during old age.
关键词intervention plasticity aging fMRI functional connectivity
收录类别SCI
语种英语
WOS记录号WOS:000332607600001
引用统计
被引频次:37[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13479
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Ctr Aging Psychol, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
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Li, Rui,Zhu, Xinyi,Yin, Shufei,et al. Multimodal intervention in older adults improves resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe[J]. FRONTIERS IN AGING NEUROSCIENCE,2014,6(0):39.
APA Li, Rui.,Zhu, Xinyi.,Yin, Shufei.,Niu, Yanan.,Zheng, Zhiwei.,...&Li, Juan.(2014).Multimodal intervention in older adults improves resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe.FRONTIERS IN AGING NEUROSCIENCE,6(0),39.
MLA Li, Rui,et al."Multimodal intervention in older adults improves resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe".FRONTIERS IN AGING NEUROSCIENCE 6.0(2014):39.
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