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Varied behavioral responses induced by morphine in the tree shrew: a possible model for human opiate addiction
Shen, Fang1; Duan, Ying1,2; Jin, Shubo1,2; Sui, Nan1
2014-09-23
Source PublicationFRONTIERS IN BEHAVIORAL NEUROSCIENCE
ISSN1662-5153
SubtypeArticle
Volume8Issue:0Pages:333
AbstractTree shrews represent a suitable animal model to study the pathogenesis of human diseases as they are phylogenetically close to primates and have a well-developed central nervous system that possesses many homologies with primates. Therefore, in our study, we investigated whether tree shrews can be used to explore the addictive behaviors induced by morphine. Firstly, to investigate the psychoactive effect of morphine on tree shrews' behavior, the number of jumping and shuttling, which represent the vertical and horizontal locomotor activity respectively, was examined following the injection of different dosage of morphine. Our results showed intramuscular OM) injection of morphine (5 or 10 mg/kg) significantly increased the locomotor activity of tree shrews 30-60 min post injection Then, using the conditioned place preference/aversion (CPP/CPA) paradigm, we found morphine-conditioned tree shrews exhibited place preference in the morphine-paired chamber on the test day. In addition, naloxone-precipitated withdrawal induced place aversion in the chronic morphine-dependent tree shrews. We evaluated the craving for morphine drinking by assessing the break point that reflects the maximum effort animals will expend to get the drug. Our data showed the break point was significantly increased when compared to the baseline on the 1st, 7th and 14th day after the abstinence. Moreover, in the intravenous morphine self-administration experiment, tree shrews conditioned with morphine responded on the active lever significantly more frequently than on the inactive lever after training. These results suggest that tree shrew may be a potential candidate for study the addictive behaviors and the underling neurological mechanisms.
KeywordTree Shrews Morphine Locomotor Activities Conditioned Place Preference/aversion (Cpp/cpa) Self-administration
Indexed BySCI
Language英语
WOS IDWOS:000342032700001
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13483
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Shen, Fang,Duan, Ying,Jin, Shubo,et al. Varied behavioral responses induced by morphine in the tree shrew: a possible model for human opiate addiction[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2014,8(0):333.
APA Shen, Fang,Duan, Ying,Jin, Shubo,&Sui, Nan.(2014).Varied behavioral responses induced by morphine in the tree shrew: a possible model for human opiate addiction.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,8(0),333.
MLA Shen, Fang,et al."Varied behavioral responses induced by morphine in the tree shrew: a possible model for human opiate addiction".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 8.0(2014):333.
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