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Okadaic acid blocks the effects of 5-aza-2-deoxycytidine on consolidation, acquisition and retrieval of morphine-induced place preference in rats
Zhang, Jian-Jun1; Han, Jin1,2; Sui, Nan1
First AuthorZhang, Jian-Jun
2014-11-01
Source PublicationNEUROPHARMACOLOGY
ISSN0028-3908
SubtypeArticle
Volume86Issue:0Pages:282-293
QuartileQ1
Contribution Rank1
Abstract

Recent studies indicated that epigenetic modification, especially DNA methylation, play an important role in the persistence of addiction-related memory. 5-aza-2-deoxycytidine (5-aza), an inhibitor of DNA methyltransferases, was approved for clinical treatment. However, it is not clear whether 5-aza is involved in opiate addiction. In this study, using the morphine-induced conditioned place preference (mCPP) model in rats, we injected 5-aza into hippocampus (CA1) and prelimbic cortex (PL), and tested the behavioral consequences at various stages of consolidation, acquisition and retrieval. Moreover, to test whether protein phosphatase regulates the effects of 5-aza, protein phosphatase (PP) 1/2A inhibitor okadaic acid (OA) was infused before 5-aza injection. We found that 5-aza injection into CA1 but not into PL significantly attenuated the consolidation and acquisition of mCPP, however, the inhibition of DNA methylation in PL but not in CA1 enhanced the retrieval of mCPP. All these behavioral effects were absent when OA was infused before 5-aza injection. These findings suggest that 5-aza interfere opiate-related memory, and protein phosphatase plays an important role in this process. (C) 2014 Elsevier Ltd. All rights reserved.

KeywordDNA methylation Okadaic acid Morphine addiction Conditioned place preference Hippocampus Prelimbic cortex
Indexed BySCI
Language英语
WOS IDWOS:000343839800029
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13484
Collection中国科学院心理健康重点实验室
Corresponding AuthorSui, Nan
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zhang, Jian-Jun,Han, Jin,Sui, Nan. Okadaic acid blocks the effects of 5-aza-2-deoxycytidine on consolidation, acquisition and retrieval of morphine-induced place preference in rats[J]. NEUROPHARMACOLOGY,2014,86(0):282-293.
APA Zhang, Jian-Jun,Han, Jin,&Sui, Nan.(2014).Okadaic acid blocks the effects of 5-aza-2-deoxycytidine on consolidation, acquisition and retrieval of morphine-induced place preference in rats.NEUROPHARMACOLOGY,86(0),282-293.
MLA Zhang, Jian-Jun,et al."Okadaic acid blocks the effects of 5-aza-2-deoxycytidine on consolidation, acquisition and retrieval of morphine-induced place preference in rats".NEUROPHARMACOLOGY 86.0(2014):282-293.
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