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Okadaic acid blocks the effects of 5-aza-2-deoxycytidine on consolidation, acquisition and retrieval of morphine-induced place preference in rats | |
Zhang, Jian-Jun1![]() ![]() | |
第一作者 | Zhang, Jian-Jun |
心理所单位排序 | 1 |
摘要 | Recent studies indicated that epigenetic modification, especially DNA methylation, play an important role in the persistence of addiction-related memory. 5-aza-2-deoxycytidine (5-aza), an inhibitor of DNA methyltransferases, was approved for clinical treatment. However, it is not clear whether 5-aza is involved in opiate addiction. In this study, using the morphine-induced conditioned place preference (mCPP) model in rats, we injected 5-aza into hippocampus (CA1) and prelimbic cortex (PL), and tested the behavioral consequences at various stages of consolidation, acquisition and retrieval. Moreover, to test whether protein phosphatase regulates the effects of 5-aza, protein phosphatase (PP) 1/2A inhibitor okadaic acid (OA) was infused before 5-aza injection. We found that 5-aza injection into CA1 but not into PL significantly attenuated the consolidation and acquisition of mCPP, however, the inhibition of DNA methylation in PL but not in CA1 enhanced the retrieval of mCPP. All these behavioral effects were absent when OA was infused before 5-aza injection. These findings suggest that 5-aza interfere opiate-related memory, and protein phosphatase plays an important role in this process. (C) 2014 Elsevier Ltd. All rights reserved. |
关键词 | DNA methylation Okadaic acid Morphine addiction Conditioned place preference Hippocampus Prelimbic cortex |
2014-11-01 | |
语种 | 英语 |
发表期刊 | NEUROPHARMACOLOGY
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ISSN | 0028-3908 |
卷号 | 86期号:0页码:282-293 |
期刊论文类型 | Article |
收录类别 | SCI |
WOS记录号 | WOS:000343839800029 |
Q分类 | Q1 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/13484 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Sui, Nan |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
第一作者单位 | 中国科学院心理健康重点实验室 |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Zhang, Jian-Jun,Han, Jin,Sui, Nan. Okadaic acid blocks the effects of 5-aza-2-deoxycytidine on consolidation, acquisition and retrieval of morphine-induced place preference in rats[J]. NEUROPHARMACOLOGY,2014,86(0):282-293. |
APA | Zhang, Jian-Jun,Han, Jin,&Sui, Nan.(2014).Okadaic acid blocks the effects of 5-aza-2-deoxycytidine on consolidation, acquisition and retrieval of morphine-induced place preference in rats.NEUROPHARMACOLOGY,86(0),282-293. |
MLA | Zhang, Jian-Jun,et al."Okadaic acid blocks the effects of 5-aza-2-deoxycytidine on consolidation, acquisition and retrieval of morphine-induced place preference in rats".NEUROPHARMACOLOGY 86.0(2014):282-293. |
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