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Okadaic acid blocks the effects of 5-aza-2-deoxycytidine on consolidation, acquisition and retrieval of morphine-induced place preference in rats
Zhang, Jian-Jun1; Han, Jin1,2; Sui, Nan1
第一作者Zhang, Jian-Jun
2014-11-01
发表期刊NEUROPHARMACOLOGY
ISSN0028-3908
文章类型Article
卷号86期号:0页码:282-293
Q分类Q1
产权排序1
摘要

Recent studies indicated that epigenetic modification, especially DNA methylation, play an important role in the persistence of addiction-related memory. 5-aza-2-deoxycytidine (5-aza), an inhibitor of DNA methyltransferases, was approved for clinical treatment. However, it is not clear whether 5-aza is involved in opiate addiction. In this study, using the morphine-induced conditioned place preference (mCPP) model in rats, we injected 5-aza into hippocampus (CA1) and prelimbic cortex (PL), and tested the behavioral consequences at various stages of consolidation, acquisition and retrieval. Moreover, to test whether protein phosphatase regulates the effects of 5-aza, protein phosphatase (PP) 1/2A inhibitor okadaic acid (OA) was infused before 5-aza injection. We found that 5-aza injection into CA1 but not into PL significantly attenuated the consolidation and acquisition of mCPP, however, the inhibition of DNA methylation in PL but not in CA1 enhanced the retrieval of mCPP. All these behavioral effects were absent when OA was infused before 5-aza injection. These findings suggest that 5-aza interfere opiate-related memory, and protein phosphatase plays an important role in this process. (C) 2014 Elsevier Ltd. All rights reserved.

关键词DNA methylation Okadaic acid Morphine addiction Conditioned place preference Hippocampus Prelimbic cortex
收录类别SCI
语种英语
WOS记录号WOS:000343839800029
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13484
专题中国科学院心理健康重点实验室
通讯作者Sui, Nan
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
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Zhang, Jian-Jun,Han, Jin,Sui, Nan. Okadaic acid blocks the effects of 5-aza-2-deoxycytidine on consolidation, acquisition and retrieval of morphine-induced place preference in rats[J]. NEUROPHARMACOLOGY,2014,86(0):282-293.
APA Zhang, Jian-Jun,Han, Jin,&Sui, Nan.(2014).Okadaic acid blocks the effects of 5-aza-2-deoxycytidine on consolidation, acquisition and retrieval of morphine-induced place preference in rats.NEUROPHARMACOLOGY,86(0),282-293.
MLA Zhang, Jian-Jun,et al."Okadaic acid blocks the effects of 5-aza-2-deoxycytidine on consolidation, acquisition and retrieval of morphine-induced place preference in rats".NEUROPHARMACOLOGY 86.0(2014):282-293.
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