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Insula-amygdala functional connectivity is correlated with habituation to repeated negative images
Denny, Bryan T.1; Fan, Jin1,2,3; Liu, Xun4; Guerreri, Stephanie1; Mayson, Sarah Jo1; Rimsky, Liza1; New, Antonia S.1,5; Siever, Larry J.1,5; Koenigsberg, Harold W.1,5
2014-11-01
Source PublicationSOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
ISSN1749-5016
SubtypeArticle
Volume9Issue:11Pages:1660-1667
AbstractBehavioral habituation during repeated exposure to aversive stimuli is an adaptive process. However, the way in which changes in self-reported emotional experience are related to the neural mechanisms supporting habituation remains unclear. We probed these mechanisms by repeatedly presenting negative images to healthy adult participants and recording behavioral and neural responses using functional magnetic resonance imaging. We were particularly interested in investigating patterns of activity in insula, given its significant role in affective integration, and in amygdala, given its association with appraisal of aversive stimuli and its frequent coactivation with insula. We found significant habituation behaviorally along with decreases in amygdala, occipital cortex and ventral prefrontal cortex (PFC) activity with repeated presentation, whereas bilateral posterior insula, dorsolateral PFC and precuneus showed increased activation. Posterior insula activation during image presentation was correlated with greater negative affect ratings for novel presentations of negative images. Further, repeated negative image presentation was associated with increased functional connectivity between left posterior insula and amygdala, and increasing insula-amygdala functional connectivity was correlated with increasing behavioral habituation. These results suggest that habituation is subserved in part by insula-amygdala connectivity and involves a change in the activity of bottom-up affective networks.
KeywordHabituation Emotion Functional Connectivity Insula Amygdala
Indexed BySSCI
Language英语
WOS IDWOS:000345846800003
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13486
Collection认知与发展心理学研究室
Affiliation1.Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA
2.Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA
3.CUNY Queens Coll, Dept Psychol, New York, NY 11367 USA
4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
5.James J Peters VA Med Ctr, Bronx, NY 10468 USA
Recommended Citation
GB/T 7714
Denny, Bryan T.,Fan, Jin,Liu, Xun,et al. Insula-amygdala functional connectivity is correlated with habituation to repeated negative images[J]. SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE,2014,9(11):1660-1667.
APA Denny, Bryan T..,Fan, Jin.,Liu, Xun.,Guerreri, Stephanie.,Mayson, Sarah Jo.,...&Koenigsberg, Harold W..(2014).Insula-amygdala functional connectivity is correlated with habituation to repeated negative images.SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE,9(11),1660-1667.
MLA Denny, Bryan T.,et al."Insula-amygdala functional connectivity is correlated with habituation to repeated negative images".SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE 9.11(2014):1660-1667.
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