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Insula-amygdala functional connectivity is correlated with habituation to repeated negative images
Denny, Bryan T.1; Fan, Jin1,2,3; Liu, Xun4; Guerreri, Stephanie1; Mayson, Sarah Jo1; Rimsky, Liza1; New, Antonia S.1,5; Siever, Larry J.1,5; Koenigsberg, Harold W.1,5
2014-11-01
发表期刊SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
ISSN1749-5016
文章类型Article
卷号9期号:11页码:1660-1667
摘要Behavioral habituation during repeated exposure to aversive stimuli is an adaptive process. However, the way in which changes in self-reported emotional experience are related to the neural mechanisms supporting habituation remains unclear. We probed these mechanisms by repeatedly presenting negative images to healthy adult participants and recording behavioral and neural responses using functional magnetic resonance imaging. We were particularly interested in investigating patterns of activity in insula, given its significant role in affective integration, and in amygdala, given its association with appraisal of aversive stimuli and its frequent coactivation with insula. We found significant habituation behaviorally along with decreases in amygdala, occipital cortex and ventral prefrontal cortex (PFC) activity with repeated presentation, whereas bilateral posterior insula, dorsolateral PFC and precuneus showed increased activation. Posterior insula activation during image presentation was correlated with greater negative affect ratings for novel presentations of negative images. Further, repeated negative image presentation was associated with increased functional connectivity between left posterior insula and amygdala, and increasing insula-amygdala functional connectivity was correlated with increasing behavioral habituation. These results suggest that habituation is subserved in part by insula-amygdala connectivity and involves a change in the activity of bottom-up affective networks.
关键词Habituation Emotion Functional Connectivity Insula Amygdala
收录类别SSCI
语种英语
WOS记录号WOS:000345846800003
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被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13486
专题认知与发展心理学研究室
作者单位1.Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA
2.Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA
3.CUNY Queens Coll, Dept Psychol, New York, NY 11367 USA
4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
5.James J Peters VA Med Ctr, Bronx, NY 10468 USA
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Denny, Bryan T.,Fan, Jin,Liu, Xun,et al. Insula-amygdala functional connectivity is correlated with habituation to repeated negative images[J]. SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE,2014,9(11):1660-1667.
APA Denny, Bryan T..,Fan, Jin.,Liu, Xun.,Guerreri, Stephanie.,Mayson, Sarah Jo.,...&Koenigsberg, Harold W..(2014).Insula-amygdala functional connectivity is correlated with habituation to repeated negative images.SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE,9(11),1660-1667.
MLA Denny, Bryan T.,et al."Insula-amygdala functional connectivity is correlated with habituation to repeated negative images".SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE 9.11(2014):1660-1667.
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