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Neurological Soft Signs Are Not "Soft" in Brain Structure and Functional Networks: Evidence From ALE Meta-Analysis
Zhao, Qing1,2,3,4; Li, Zhi1,2; Huang, Jia1; Yan, Chao1,2; Dazzan, Paola5; Pantelis, Christos6,7; Cheung, Eric F. C.8; Lui, Simon S. Y.1,2,8; Chan, Raymond C. K.1
2014-05-01
发表期刊SCHIZOPHRENIA BULLETIN
ISSN0586-7614
文章类型Article
卷号40期号:3页码:626-641
摘要Background: Neurological soft signs (NSS) are associated with schizophrenia and related psychotic disorders. NSS have been conventionally considered as clinical neurological signs without localized brain regions. However, recent brain imaging studies suggest that NSS are partly localizable and may be associated with deficits in specific brain areas. Method: We conducted an activation likelihood estimation meta-analysis to quantitatively review structural and functional imaging studies that evaluated the brain correlates of NSS in patients with schizophrenia and other psychotic disorders. Six structural magnetic resonance imaging (sMRI) and 15 functional magnetic -resonance imaging (fMRI) studies were included. Results: The results from meta-analysis of the sMRI studies-indicated that NSS were associated with atrophy of the precentral gyrus, the cerebellum, the inferior frontal gyrus, and the thalamus. The results from meta-analysis of the fMRI studies demonstrated that the NSS-related task was significantly associated with altered brain activation in the inferior frontal gyrus, bilateral putamen, the cerebellum, and the superior temporal gyrus. Conclusions: Ourfindings from both sMRI and fMRI meta-analyses further support the conceptualization of NSS as a manifestation of the "cerebello-thalamo-prefrontal" brain network model of schizophrenia and related psychotic disorders.
关键词neurological soft signs brain imaging activation likelihood estimation meta-analysis schizophrenia psychosis
收录类别SSCI
语种英语
WOS记录号WOS:000334750800021
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被引频次:52[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13490
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Key Lab Mental Hlth, Beijing, Peoples R China
3.Griffith Univ, Sch Appl Psychol, Brisbane, Qld 4111, Australia
4.Griffith Univ, Griffith Hlth Inst, Behav Basis Hlth Program, Brisbane, Qld 4111, Australia
5.Inst Psychiat, Dept Psychosis Studies, London, England
6.Univ Melbourne, Melbourne Neuropsychiat Ctr, Melbourne, Vic, Australia
7.Melbourne Hlth, Melbourne, Vic, Australia
8.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
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Zhao, Qing,Li, Zhi,Huang, Jia,et al. Neurological Soft Signs Are Not "Soft" in Brain Structure and Functional Networks: Evidence From ALE Meta-Analysis[J]. SCHIZOPHRENIA BULLETIN,2014,40(3):626-641.
APA Zhao, Qing.,Li, Zhi.,Huang, Jia.,Yan, Chao.,Dazzan, Paola.,...&Chan, Raymond C. K..(2014).Neurological Soft Signs Are Not "Soft" in Brain Structure and Functional Networks: Evidence From ALE Meta-Analysis.SCHIZOPHRENIA BULLETIN,40(3),626-641.
MLA Zhao, Qing,et al."Neurological Soft Signs Are Not "Soft" in Brain Structure and Functional Networks: Evidence From ALE Meta-Analysis".SCHIZOPHRENIA BULLETIN 40.3(2014):626-641.
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