Neurological Soft Signs Are Not "Soft" in Brain Structure and Functional Networks: Evidence From ALE Meta-Analysis

	Neurological Soft Signs Are Not "Soft" in Brain Structure and Functional Networks: Evidence From ALE Meta-Analysis
	Zhao, Qing1,2,3,4 ; Li, Zhi 1,2; Huang, Jia1 ; Yan, Chao1,2 ; Dazzan, Paola 5; Pantelis, Christos 6,7; Cheung, Eric F. C.8; Lui, Simon S. Y.1,2,8; Chan, Raymond C. K.1
摘要	Background: Neurological soft signs (NSS) are associated with schizophrenia and related psychotic disorders. NSS have been conventionally considered as clinical neurological signs without localized brain regions. However, recent brain imaging studies suggest that NSS are partly localizable and may be associated with deficits in specific brain areas. Method: We conducted an activation likelihood estimation meta-analysis to quantitatively review structural and functional imaging studies that evaluated the brain correlates of NSS in patients with schizophrenia and other psychotic disorders. Six structural magnetic resonance imaging (sMRI) and 15 functional magnetic -resonance imaging (fMRI) studies were included. Results: The results from meta-analysis of the sMRI studies-indicated that NSS were associated with atrophy of the precentral gyrus, the cerebellum, the inferior frontal gyrus, and the thalamus. The results from meta-analysis of the fMRI studies demonstrated that the NSS-related task was significantly associated with altered brain activation in the inferior frontal gyrus, bilateral putamen, the cerebellum, and the superior temporal gyrus. Conclusions: Ourfindings from both sMRI and fMRI meta-analyses further support the conceptualization of NSS as a manifestation of the "cerebello-thalamo-prefrontal" brain network model of schizophrenia and related psychotic disorders.
关键词	neurological soft signs brain imaging activation likelihood estimation meta-analysis schizophrenia psychosis
	2014-05-01
语种	英语
发表期刊	SCHIZOPHRENIA BULLETIN
ISSN	0586-7614
卷号	40 期号:3 页码:626-641
期刊论文类型	Article
收录类别	SSCI
WOS记录号	WOS:000334750800021
引用统计	被引频次：105[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/13490
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Key Lab Mental Hlth, Beijing, Peoples R China 3.Griffith Univ, Sch Appl Psychol, Brisbane, Qld 4111, Australia 4.Griffith Univ, Griffith Hlth Inst, Behav Basis Hlth Program, Brisbane, Qld 4111, Australia 5.Inst Psychiat, Dept Psychosis Studies, London, England 6.Univ Melbourne, Melbourne Neuropsychiat Ctr, Melbourne, Vic, Australia 7.Melbourne Hlth, Melbourne, Vic, Australia 8.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
第一作者单位	认知与发展心理学研究室; 中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Zhao, Qing,Li, Zhi,Huang, Jia,et al. Neurological Soft Signs Are Not "Soft" in Brain Structure and Functional Networks: Evidence From ALE Meta-Analysis[J]. SCHIZOPHRENIA BULLETIN,2014,40(3):626-641.
APA	Zhao, Qing.,Li, Zhi.,Huang, Jia.,Yan, Chao.,Dazzan, Paola.,...&Chan, Raymond C. K..(2014).Neurological Soft Signs Are Not "Soft" in Brain Structure and Functional Networks: Evidence From ALE Meta-Analysis.SCHIZOPHRENIA BULLETIN,40(3),626-641.
MLA	Zhao, Qing,et al."Neurological Soft Signs Are Not "Soft" in Brain Structure and Functional Networks: Evidence From ALE Meta-Analysis".SCHIZOPHRENIA BULLETIN 40.3(2014):626-641.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
WOS_000334750800021.（13214KB）	期刊论文	出版稿	暂不开放	CC BY-NC-SA	请求全文