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Cinnamic aldehyde treatment alleviates chronic unexpected stress-induced depressive-like behaviors via targeting cyclooxygenase-2 in mid-aged rats
Yao, Ying1; Huang, Hai-Ying2; Yang, Yuan-Xiao3; Guo, Jian-You4
2015-03-13
发表期刊JOURNAL OF ETHNOPHARMACOLOGY
ISSN0378-8741
文章类型Article
卷号162期号:0页码:97-103
摘要Ethnopharmacological relevance: COX-2 has been considered as a potent molecular target for prevention and therapy of depression. However, a recent study showed that COX-2 inhibitor does not improve depressive symptoms in persons aged 70 and over. Therefore, whether treatments targeting COX-2 have a clinical efficacy in depression, especially elderly individuals, remains unclear. Cinnamic aldehyde is a major constituent of Cinnamomum cassia, which has exhibited excellent anti-inflammatory activities as a COX-2 inhibitor. To investigate the potential antidepressant effect of cinnamic aldehyde in mid-aged rats.
关键词Aged Depression Cinnamic aldehyde Cyclooxygenase-2 Prostaglandin E2
收录类别SCI
语种英语
WOS记录号WOS:000351323400013
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13498
专题中国科学院心理健康重点实验室
作者单位1.Zhejiang Med Coll, Dept Pharm, Hangzhou 310053, Zhejiang, Peoples R China
2.Henan Univ Tradit Chinese Med, Sch Pharm, Zhengzhou 450046, Peoples R China
3.Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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GB/T 7714
Yao, Ying,Huang, Hai-Ying,Yang, Yuan-Xiao,et al. Cinnamic aldehyde treatment alleviates chronic unexpected stress-induced depressive-like behaviors via targeting cyclooxygenase-2 in mid-aged rats[J]. JOURNAL OF ETHNOPHARMACOLOGY,2015,162(0):97-103.
APA Yao, Ying,Huang, Hai-Ying,Yang, Yuan-Xiao,&Guo, Jian-You.(2015).Cinnamic aldehyde treatment alleviates chronic unexpected stress-induced depressive-like behaviors via targeting cyclooxygenase-2 in mid-aged rats.JOURNAL OF ETHNOPHARMACOLOGY,162(0),97-103.
MLA Yao, Ying,et al."Cinnamic aldehyde treatment alleviates chronic unexpected stress-induced depressive-like behaviors via targeting cyclooxygenase-2 in mid-aged rats".JOURNAL OF ETHNOPHARMACOLOGY 162.0(2015):97-103.
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