Institutional Repository of Key Laboratory of Mental Health, CAS
Rostral medial prefrontal dysfunctions and consummatory pleasure in schizophrenia: A meta-analysis of functional imaging studies | |
Yan, Chao1,2,3; Yang, Tammy2; Yu, Qi-jing2; Jin, Zhen4; Cheung, Eric F. C.5; Liu, Xun6,7; Chan, Raymond C. K.2,7 | |
摘要 | A large number of imaging studies have examined the neural correlates of consummatory pleasure and anticipatory pleasure in schizophrenia, but the brain regions where schizophrenia patients consistently demonstrate dysfunctions remain unclear. We performed a series of meta-analyses on imaging studies to delineate the regions associated with consummatory and anticipatory pleasure dysfunctions in schizophrenia. Nineteen functional magnetic resonance imaging or positron emission tomography studies using whole brain analysis were identified through a literature search (PubMed and EBSCO; januaiy 1990-February 2014). Activation likelihood estimation was performed using the GingerALE software. The clusters identified were obtained after controlling for the false discovery rate at p<0.05 and applying a minimum cluster size of 200 mm(3). It was found that schizophrenia patients exhibited decreased activation mainly in the rostral medial prefrontal cortex (rmPFC), the right parahippocampus/ amygala, and other limbic regions (e.g., the subgenual anterior cingulate cortex, the putamen, and the medial globus pallidus) when consummating pleasure. Task instructions (feeling vs stimuli) were differentially related to medial prefrontal dysfunction in schizophrenia. When patients anticipated pleasure, reduced activation in the left putamen was observed, despite the limited number of studies. Our findings suggest that the medial prefrontal cortex and limbic regions may play an important role in neural dysfunction underlying deficits in consummatory pleasure in schizophrenia. (C) 2015 Elsevier Ireland Ltd. All rights reserved. |
关键词 | Schizophrenia Consummately pleasure Anticipatory pleasure Activation likelihood estimation Medial prefrontal cortex |
2015-03-30 | |
语种 | 英语 |
发表期刊 | PSYCHIATRY RESEARCH-NEUROIMAGING |
ISSN | 0925-4927 |
卷号 | 231期号:3页码:187-196 |
期刊论文类型 | Review |
收录类别 | SCI |
WOS记录号 | WOS:000351311000001 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/13505 |
专题 | 中国科学院心理健康重点实验室 |
作者单位 | 1.Shanghai Key Lab Brain Funct Genom MOE STCSM, China Normal Univ, Sch Psychol & Cognit Sci, Shanghai, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Beijing 306 Hosp, Beijing, Peoples R China 5.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 6.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China 7.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China |
第一作者单位 | 认知与发展心理学研究室 |
推荐引用方式 GB/T 7714 | Yan, Chao,Yang, Tammy,Yu, Qi-jing,et al. Rostral medial prefrontal dysfunctions and consummatory pleasure in schizophrenia: A meta-analysis of functional imaging studies[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2015,231(3):187-196. |
APA | Yan, Chao.,Yang, Tammy.,Yu, Qi-jing.,Jin, Zhen.,Cheung, Eric F. C..,...&Chan, Raymond C. K..(2015).Rostral medial prefrontal dysfunctions and consummatory pleasure in schizophrenia: A meta-analysis of functional imaging studies.PSYCHIATRY RESEARCH-NEUROIMAGING,231(3),187-196. |
MLA | Yan, Chao,et al."Rostral medial prefrontal dysfunctions and consummatory pleasure in schizophrenia: A meta-analysis of functional imaging studies".PSYCHIATRY RESEARCH-NEUROIMAGING 231.3(2015):187-196. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
WOS_000351311000001 (1642KB) | 期刊论文 | 出版稿 | 暂不开放 | CC BY-NC-SA | 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论