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Rostral medial prefrontal dysfunctions and consummatory pleasure in schizophrenia: A meta-analysis of functional imaging studies
Yan, Chao1,2,3; Yang, Tammy2; Yu, Qi-jing2; Jin, Zhen4; Cheung, Eric F. C.5; Liu, Xun6,7; Chan, Raymond C. K.2,7
2015-03-30
Source PublicationPSYCHIATRY RESEARCH-NEUROIMAGING
ISSN0925-4927
SubtypeReview
Volume231Issue:3Pages:187-196
AbstractA large number of imaging studies have examined the neural correlates of consummatory pleasure and anticipatory pleasure in schizophrenia, but the brain regions where schizophrenia patients consistently demonstrate dysfunctions remain unclear. We performed a series of meta-analyses on imaging studies to delineate the regions associated with consummatory and anticipatory pleasure dysfunctions in schizophrenia. Nineteen functional magnetic resonance imaging or positron emission tomography studies using whole brain analysis were identified through a literature search (PubMed and EBSCO; januaiy 1990-February 2014). Activation likelihood estimation was performed using the GingerALE software. The clusters identified were obtained after controlling for the false discovery rate at p<0.05 and applying a minimum cluster size of 200 mm(3). It was found that schizophrenia patients exhibited decreased activation mainly in the rostral medial prefrontal cortex (rmPFC), the right parahippocampus/ amygala, and other limbic regions (e.g., the subgenual anterior cingulate cortex, the putamen, and the medial globus pallidus) when consummating pleasure. Task instructions (feeling vs stimuli) were differentially related to medial prefrontal dysfunction in schizophrenia. When patients anticipated pleasure, reduced activation in the left putamen was observed, despite the limited number of studies. Our findings suggest that the medial prefrontal cortex and limbic regions may play an important role in neural dysfunction underlying deficits in consummatory pleasure in schizophrenia. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
KeywordSchizophrenia Consummately pleasure Anticipatory pleasure Activation likelihood estimation Medial prefrontal cortex
Indexed BySCI
Language英语
WOS IDWOS:000351311000001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13505
Collection中国科学院心理健康重点实验室
Affiliation1.Shanghai Key Lab Brain Funct Genom MOE STCSM, China Normal Univ, Sch Psychol & Cognit Sci, Shanghai, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Beijing 306 Hosp, Beijing, Peoples R China
5.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
6.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
7.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Yan, Chao,Yang, Tammy,Yu, Qi-jing,et al. Rostral medial prefrontal dysfunctions and consummatory pleasure in schizophrenia: A meta-analysis of functional imaging studies[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2015,231(3):187-196.
APA Yan, Chao.,Yang, Tammy.,Yu, Qi-jing.,Jin, Zhen.,Cheung, Eric F. C..,...&Chan, Raymond C. K..(2015).Rostral medial prefrontal dysfunctions and consummatory pleasure in schizophrenia: A meta-analysis of functional imaging studies.PSYCHIATRY RESEARCH-NEUROIMAGING,231(3),187-196.
MLA Yan, Chao,et al."Rostral medial prefrontal dysfunctions and consummatory pleasure in schizophrenia: A meta-analysis of functional imaging studies".PSYCHIATRY RESEARCH-NEUROIMAGING 231.3(2015):187-196.
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