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Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia
Zhou, Yuan1,2; Fan, Lingzhong3,4; Qiu, Chenxiang3,4; Jiang, Tianzi3,4,5,6
2015-04-01
Source PublicationNEUROSCIENCE BULLETIN
ISSN1673-7067
SubtypeReview
Volume31Issue:2Pages:207-219
AbstractSchizophrenia is hypothesized to arise from disrupted brain connectivity. This "dysconnectivity hypothesis" has generated interest in discovering whether there is anatomical and functional dysconnectivity between the prefrontal cortex (PFC) and other brain regions, and how this dysconnectivity is linked to the impaired cognitive functions and aberrant behaviors of schizophrenia. Critical advances in neuroimaging technologies, including diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI), make it possible to explore these issues. DTI affords the possibility to explore anatomical connectivity in the human brain in vivo and fMRI can be used to make inferences about functional connections between brain regions. In this review, we present major advances in the understanding of PFC anatomical and functional dysconnectivity and their implications in schizophrenia. We then briefly discuss future prospects that need to be explored in order to move beyond simple mapping of connectivity changes to elucidate the neuronal mechanisms underlying schizophrenia.
Keywordprefrontal cortex schizophrenia anatomical connectivity functional connectivity
Indexed BySCI
Language英语
WOS IDWOS:000352152800007
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13515
Collection中国科学院行为科学重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
6.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Yuan,Fan, Lingzhong,Qiu, Chenxiang,et al. Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia[J]. NEUROSCIENCE BULLETIN,2015,31(2):207-219.
APA Zhou, Yuan,Fan, Lingzhong,Qiu, Chenxiang,&Jiang, Tianzi.(2015).Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia.NEUROSCIENCE BULLETIN,31(2),207-219.
MLA Zhou, Yuan,et al."Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia".NEUROSCIENCE BULLETIN 31.2(2015):207-219.
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