Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia

	Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia
	Zhou, Yuan1,2 ; Fan, Lingzhong 3,4; Qiu, Chenxiang 3,4; Jiang, Tianzi 3,4,5,6
摘要	Schizophrenia is hypothesized to arise from disrupted brain connectivity. This "dysconnectivity hypothesis" has generated interest in discovering whether there is anatomical and functional dysconnectivity between the prefrontal cortex (PFC) and other brain regions, and how this dysconnectivity is linked to the impaired cognitive functions and aberrant behaviors of schizophrenia. Critical advances in neuroimaging technologies, including diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI), make it possible to explore these issues. DTI affords the possibility to explore anatomical connectivity in the human brain in vivo and fMRI can be used to make inferences about functional connections between brain regions. In this review, we present major advances in the understanding of PFC anatomical and functional dysconnectivity and their implications in schizophrenia. We then briefly discuss future prospects that need to be explored in order to move beyond simple mapping of connectivity changes to elucidate the neuronal mechanisms underlying schizophrenia.
关键词	prefrontal cortex schizophrenia anatomical connectivity functional connectivity
	2015-04-01
语种	英语
发表期刊	NEUROSCIENCE BULLETIN
ISSN	1673-7067
卷号	31 期号:2 页码:207-219
期刊论文类型	Review
收录类别	SCI
WOS记录号	WOS:000352152800007
引用统计	被引频次：122[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/13515
专题	中国科学院行为科学重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia 6.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China
第一作者单位	中国科学院行为科学重点实验室; 管理支撑系统
推荐引用方式 GB/T 7714	Zhou, Yuan,Fan, Lingzhong,Qiu, Chenxiang,et al. Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia[J]. NEUROSCIENCE BULLETIN,2015,31(2):207-219.
APA	Zhou, Yuan,Fan, Lingzhong,Qiu, Chenxiang,&Jiang, Tianzi.(2015).Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia.NEUROSCIENCE BULLETIN,31(2),207-219.
MLA	Zhou, Yuan,et al."Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia".NEUROSCIENCE BULLETIN 31.2(2015):207-219.

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