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Genetic linkage analysis in the age of whole-genome sequencing
Ott, Jurg1,2; Wang, Jing1; Leal, Suzanne M.3
2015-05-01
发表期刊NATURE REVIEWS GENETICS
ISSN1471-0056
文章类型Review
卷号16期号:5页码:275-284
摘要For many years, linkage analysis was the primary tool used for the genetic mapping of Mendelian and complex traits with familial aggregation. Linkage analysis was largely supplanted by the wide adoption of genome-wide association studies (GWASs). However, with the recent increased use of whole-genome sequencing (WGS), linkage analysis is again emerging as an important and powerful analysis method for the identification of genes involved in disease aetiology, often in conjunction with WGS filtering approaches. Here, we review the principles of linkage analysis and provide practical guidelines for carrying out linkage studies using WGS data.
收录类别SCI
语种英语
WOS记录号WOS:000353164800009
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被引频次:71[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13523
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Rockefeller Univ, Lab Stat Genet, New York, NY 10065 USA
3.Baylor Coll Med, Dept Human & Mol Genet, Ctr Stat Genet, Houston, TX 77030 USA
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Ott, Jurg,Wang, Jing,Leal, Suzanne M.. Genetic linkage analysis in the age of whole-genome sequencing[J]. NATURE REVIEWS GENETICS,2015,16(5):275-284.
APA Ott, Jurg,Wang, Jing,&Leal, Suzanne M..(2015).Genetic linkage analysis in the age of whole-genome sequencing.NATURE REVIEWS GENETICS,16(5),275-284.
MLA Ott, Jurg,et al."Genetic linkage analysis in the age of whole-genome sequencing".NATURE REVIEWS GENETICS 16.5(2015):275-284.
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