Genetic linkage analysis in the age of whole-genome sequencing

	Genetic linkage analysis in the age of whole-genome sequencing
	Ott, Jurg 1,2; Wang, Jing1 ; Leal, Suzanne M.3
摘要	For many years, linkage analysis was the primary tool used for the genetic mapping of Mendelian and complex traits with familial aggregation. Linkage analysis was largely supplanted by the wide adoption of genome-wide association studies (GWASs). However, with the recent increased use of whole-genome sequencing (WGS), linkage analysis is again emerging as an important and powerful analysis method for the identification of genes involved in disease aetiology, often in conjunction with WGS filtering approaches. Here, we review the principles of linkage analysis and provide practical guidelines for carrying out linkage studies using WGS data.
	2015-05-01
语种	英语
发表期刊	NATURE REVIEWS GENETICS
ISSN	1471-0056
卷号	16 期号:5 页码:275-284
期刊论文类型	Review
收录类别	SCI
WOS记录号	WOS:000353164800009
引用统计	被引频次：181[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/13523
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Rockefeller Univ, Lab Stat Genet, New York, NY 10065 USA 3.Baylor Coll Med, Dept Human & Mol Genet, Ctr Stat Genet, Houston, TX 77030 USA
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Ott, Jurg,Wang, Jing,Leal, Suzanne M.. Genetic linkage analysis in the age of whole-genome sequencing[J]. NATURE REVIEWS GENETICS,2015,16(5):275-284.
APA	Ott, Jurg,Wang, Jing,&Leal, Suzanne M..(2015).Genetic linkage analysis in the age of whole-genome sequencing.NATURE REVIEWS GENETICS,16(5),275-284.
MLA	Ott, Jurg,et al."Genetic linkage analysis in the age of whole-genome sequencing".NATURE REVIEWS GENETICS 16.5(2015):275-284.

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