Institutional Repository of Key Laboratory of Mental Health, CAS
Genetic linkage analysis in the age of whole-genome sequencing | |
Ott, Jurg1,2; Wang, Jing1![]() | |
摘要 | For many years, linkage analysis was the primary tool used for the genetic mapping of Mendelian and complex traits with familial aggregation. Linkage analysis was largely supplanted by the wide adoption of genome-wide association studies (GWASs). However, with the recent increased use of whole-genome sequencing (WGS), linkage analysis is again emerging as an important and powerful analysis method for the identification of genes involved in disease aetiology, often in conjunction with WGS filtering approaches. Here, we review the principles of linkage analysis and provide practical guidelines for carrying out linkage studies using WGS data. |
2015-05-01 | |
语种 | 英语 |
发表期刊 | NATURE REVIEWS GENETICS
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ISSN | 1471-0056 |
卷号 | 16期号:5页码:275-284 |
期刊论文类型 | Review |
收录类别 | SCI |
WOS记录号 | WOS:000353164800009 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/13523 |
专题 | 中国科学院心理健康重点实验室 |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Rockefeller Univ, Lab Stat Genet, New York, NY 10065 USA 3.Baylor Coll Med, Dept Human & Mol Genet, Ctr Stat Genet, Houston, TX 77030 USA |
第一作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Ott, Jurg,Wang, Jing,Leal, Suzanne M.. Genetic linkage analysis in the age of whole-genome sequencing[J]. NATURE REVIEWS GENETICS,2015,16(5):275-284. |
APA | Ott, Jurg,Wang, Jing,&Leal, Suzanne M..(2015).Genetic linkage analysis in the age of whole-genome sequencing.NATURE REVIEWS GENETICS,16(5),275-284. |
MLA | Ott, Jurg,et al."Genetic linkage analysis in the age of whole-genome sequencing".NATURE REVIEWS GENETICS 16.5(2015):275-284. |
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文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
WOS000353164800009.p(366KB) | 期刊论文 | 出版稿 | 暂不开放 | CC BY-NC-SA | 请求全文 |
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