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Genetic linkage analysis in the age of whole-genome sequencing
Ott, Jurg1,2; Wang, Jing1; Leal, Suzanne M.3
2015-05-01
Source PublicationNATURE REVIEWS GENETICS
ISSN1471-0056
SubtypeReview
Volume16Issue:5Pages:275-284
AbstractFor many years, linkage analysis was the primary tool used for the genetic mapping of Mendelian and complex traits with familial aggregation. Linkage analysis was largely supplanted by the wide adoption of genome-wide association studies (GWASs). However, with the recent increased use of whole-genome sequencing (WGS), linkage analysis is again emerging as an important and powerful analysis method for the identification of genes involved in disease aetiology, often in conjunction with WGS filtering approaches. Here, we review the principles of linkage analysis and provide practical guidelines for carrying out linkage studies using WGS data.
Indexed BySCI
Language英语
WOS IDWOS:000353164800009
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13523
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Rockefeller Univ, Lab Stat Genet, New York, NY 10065 USA
3.Baylor Coll Med, Dept Human & Mol Genet, Ctr Stat Genet, Houston, TX 77030 USA
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Ott, Jurg,Wang, Jing,Leal, Suzanne M.. Genetic linkage analysis in the age of whole-genome sequencing[J]. NATURE REVIEWS GENETICS,2015,16(5):275-284.
APA Ott, Jurg,Wang, Jing,&Leal, Suzanne M..(2015).Genetic linkage analysis in the age of whole-genome sequencing.NATURE REVIEWS GENETICS,16(5),275-284.
MLA Ott, Jurg,et al."Genetic linkage analysis in the age of whole-genome sequencing".NATURE REVIEWS GENETICS 16.5(2015):275-284.
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