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题名:
Genetic linkage analysis in the age of whole-genome sequencing
作者: Ott, Jurg1,2; Wang, Jing1; Leal, Suzanne M.3
文章类型: Review
刊名: NATURE REVIEWS GENETICS
ISSN号: 1471-0056
出版日期: 2015-05-01
卷号: 16, 期号:5, 页码:275-284
收录类别: SCI
英文摘要: For many years, linkage analysis was the primary tool used for the genetic mapping of Mendelian and complex traits with familial aggregation. Linkage analysis was largely supplanted by the wide adoption of genome-wide association studies (GWASs). However, with the recent increased use of whole-genome sequencing (WGS), linkage analysis is again emerging as an important and powerful analysis method for the identification of genes involved in disease aetiology, often in conjunction with WGS filtering approaches. Here, we review the principles of linkage analysis and provide practical guidelines for carrying out linkage studies using WGS data.
语种: 英语
WOS记录号: WOS:000353164800009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.psych.ac.cn/handle/311026/13523
Appears in Collections:中国科学院心理健康重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Rockefeller Univ, Lab Stat Genet, New York, NY 10065 USA
3.Baylor Coll Med, Dept Human & Mol Genet, Ctr Stat Genet, Houston, TX 77030 USA

Recommended Citation:
Ott, Jurg,Wang, Jing,Leal, Suzanne M.. Genetic linkage analysis in the age of whole-genome sequencing[J]. NATURE REVIEWS GENETICS,2015,16(5):275-284.
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