PSYCH OpenIR  > 中国科学院心理健康重点实验室
Neurobiological Changes of Schizotypy: Evidence From Both Volume-Based Morphometric Analysis and Resting-State Functional Connectivity
Wang, Yi1; Yan, Chao2; Yin, Da-zhi3; Fan, Ming-xia3; Cheung, Eric F. C.4; Pantelis, Christos5,6; Chan, Raymond C. K.1,7
2015-03-01
发表期刊SCHIZOPHRENIA BULLETIN
ISSN0586-7614
文章类型Article
卷号41期号:2页码:S444-S454
摘要The current study sought to examine the underlying brain changes in individuals with high schizotypy by integrating networks derived from brain structural and functional imaging. Individuals with high schizotypy (n = 35) and low schizotypy (n = 34) controls were screened using the Schizotypal Personality Questionnaire and underwent brain structural and resting-state functional magnetic resonance imaging on a 3T scanner. Voxel-based morphometric analysis and graph theory-based functional network analysis were conducted. Individuals with high schizotypy showed reduced gray matter (GM) density in the insula and the dorsolateral prefrontal gyrus. The graph theoretical analysis showed that individuals with high schizotypy showed similar global properties in their functional networks as low schizotypy individuals. Several hubs of the functional network were identified in both groups, including the insula, the lingual gyrus, the postcentral gyrus, and the rolandic operculum. More hubs in the frontal lobe and fewer hubs in the occipital lobe were identified in individuals with high schizotypy. By comparing the functional connectivity between clusters with abnormal GM density and the whole brain, individuals with high schizotypy showed weaker functional connectivity between the left insula and the putamen, but stronger connectivity between the cerebellum and the medial frontal gyrus. Taken together, our findings suggest that individuals with high schizotypy present changes in terms of GM and resting-state functional connectivity, especially in the frontal lobe.
关键词schizotypy voxel-based morphometry graph theory functional connectivity insula
收录类别SSCI
语种英语
WOS记录号WOS:000353548800010
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13528
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
2.E China Normal Univ, Sch Psychol & Cognit Sci, Shanghai Key Lab Brain Funct Genom MOE & STCSM, Shanghai 200062, Peoples R China
3.E China Normal Univ, Shanghai Key Lab MRI, Shanghai 200062, Peoples R China
4.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
5.Univ Melbourne, Dept Psychiat, Melbourne Neuropsychiat Ctr, Melbourne, Vic, Australia
6.Melbourne Hlth, Melbourne, Vic, Australia
7.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Ctr, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
Wang, Yi,Yan, Chao,Yin, Da-zhi,et al. Neurobiological Changes of Schizotypy: Evidence From Both Volume-Based Morphometric Analysis and Resting-State Functional Connectivity[J]. SCHIZOPHRENIA BULLETIN,2015,41(2):S444-S454.
APA Wang, Yi.,Yan, Chao.,Yin, Da-zhi.,Fan, Ming-xia.,Cheung, Eric F. C..,...&Chan, Raymond C. K..(2015).Neurobiological Changes of Schizotypy: Evidence From Both Volume-Based Morphometric Analysis and Resting-State Functional Connectivity.SCHIZOPHRENIA BULLETIN,41(2),S444-S454.
MLA Wang, Yi,et al."Neurobiological Changes of Schizotypy: Evidence From Both Volume-Based Morphometric Analysis and Resting-State Functional Connectivity".SCHIZOPHRENIA BULLETIN 41.2(2015):S444-S454.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS000353548800010.p(1041KB)期刊论文出版稿暂不开放CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Yi]的文章
[Yan, Chao]的文章
[Yin, Da-zhi]的文章
百度学术
百度学术中相似的文章
[Wang, Yi]的文章
[Yan, Chao]的文章
[Yin, Da-zhi]的文章
必应学术
必应学术中相似的文章
[Wang, Yi]的文章
[Yan, Chao]的文章
[Yin, Da-zhi]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。