Chronic unpredictable mild stress induces parallel reductions of 15-PGDH in the hypothalamus and lungs in rats

	Chronic unpredictable mild stress induces parallel reductions of 15-PGDH in the hypothalamus and lungs in rats
	Guo, Jian-You1 ; Bian, Hua 2; Yao, Ying3
摘要	Prostaglandin E-2 (PGE(2)) is an important inflammatory mediator and considered to be involved in the pathophysiology of depression. Previous studies that investigated the role of PGE(2) in depression solely concentrated on the cyclooxygenase-dependent synthesis of this bioactive lipid. However, enzymes that degrade PGE(2), such as NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH), have not yet been explored. The present study examined the expression of 15-PGDH in an animal model of depression. Depressive-like behaviors were measured after rats were exposed to chronic unpredictable mild stress (CUMS). 15 PGDH mRNA and protein expression and activity and PGE(2) levels were detected in the brain and lungs in stressed animals. The stressed animals exhibited decreases in body weight gain, locomotor activity in the open field, and sucrose preference. The hypothalamus and lungs had high baseline 15-PGDH mRNA and protein expression, whereas the frontal cortex and hippocampus showed no detectable 15-PGDH mRNA or protein expression. 15 PGDH mRNA and protein expression was significantly downregulated in the hypothalamus and lungs in stressed rats compared with control rats, and the enzymatic activity of 15-PGDH was correlated with protein expression levels. PGE(2) concentrations in the brain and serum increased in stressed rats. These results suggest the loss of 15-PGDH expression in depression, and 15-PGDH may be a novel potential pharmacological target for the treatment of depression. (C) 2015 Elsevier B.V. All rights reserved.
关键词	Stress Anhedonia Prostaglandin E-2 15-PGDH Hypothalamus
	2015-06-01
语种	英语
发表期刊	BEHAVIOURAL BRAIN RESEARCH
ISSN	0166-4328
卷号	286 期号:0 页码:278-284
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000353599600037
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/13532
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Nanyang Inst Technol, Ctr Med Expt, Nanyang 473004, Peoples R China 3.Zhejiang Med Coll, Dept Pharm, Hangzhou 310053, Zhejiang, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Guo, Jian-You,Bian, Hua,Yao, Ying. Chronic unpredictable mild stress induces parallel reductions of 15-PGDH in the hypothalamus and lungs in rats[J]. BEHAVIOURAL BRAIN RESEARCH,2015,286(0):278-284.
APA	Guo, Jian-You,Bian, Hua,&Yao, Ying.(2015).Chronic unpredictable mild stress induces parallel reductions of 15-PGDH in the hypothalamus and lungs in rats.BEHAVIOURAL BRAIN RESEARCH,286(0),278-284.
MLA	Guo, Jian-You,et al."Chronic unpredictable mild stress induces parallel reductions of 15-PGDH in the hypothalamus and lungs in rats".BEHAVIOURAL BRAIN RESEARCH 286.0(2015):278-284.

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