| Overlapping Dopaminergic Pathway Genetic Susceptibility to Heroin and Cocaine Addictions in African Americans | |
| Levran, Orna1; Randesi, Matthew1; da Rosa, Joel Correa2; Ott, Jurg3,4; Rotrosen, John5,6; Adelson, Miriam1,7; Kreek, Mary Jeanne1 | |
| 摘要 | Drugs of abuse activate the mesolimbic dopaminergic pathway. Genetic variations in the dopaminergic system may contribute to drug addiction. Several processes are shared between cocaine and heroin addictions but some neurobiological mechanisms may be specific. This study examined the association of 98 single nucleotide polymorphisms in 13 dopamine-related genes with heroin addiction (OD) and/or cocaine addiction (CD) in a sample of 801 African Americans (315 subjects with OD +/- CD, 279 subjects with CD, and 207 controls). Single-marker analyses provided nominally significant evidence for associations of 24 SNPs) in DRD1, ANKK1/DRD2, DRD3, DRD5, DBH, DDC, COMT and CSNK1E. A DRD2 7-SNPs haplotype that includes SNPs rs1075650 and rs2283265, which were shown to alter D2S/D2L splicing, was indicated in both addictions. The Met allele of the functional COMT Val158Met was associated with protection from OD. None of the signals remained significant after correction for multiple testing. The study results are in accordance with the results of previous studies, including our report of association of DRD1 SNP rs5326 with OD. The findings suggest the presence of an overlap in genetic susceptibility for OD and CD, as well as shared and distinct susceptibility for OD in subjects of African and European descent. |
| 关键词 | Dopaminergic pathway polymorphism heroin addiction cocaine addiction African Americans DRD1 DRD2 COMT Val158Met rs5326 rs1075650 rs2283265 |
| 2015-05-01 | |
| 语种 | 英语 |
| 发表期刊 | ANNALS OF HUMAN GENETICS
 |
| ISSN | 0003-4800 |
| 卷号 | 79期号:3页码:188-198 |
| 期刊论文类型 | Article |
| 收录类别 | SCI |
| WOS记录号 | WOS:000353646400004 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/13533 |
| 专题 | 健康与遗传心理学研究室 |
| 作者单位 | 1.Rockefeller Univ, Lab Biol Addict Dis, New York, NY 10065 USA 2.Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10065 USA 3.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 4.Rockefeller Univ, Lab Stat Genet, New York, NY 10065 USA 5.VA New York Harbor Healthcare Syst, New York, NY USA 6.NYU, Sch Med, New York, NY USA 7.Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, Las Vegas, NV USA |
| 推荐引用方式 GB/T 7714 | Levran, Orna,Randesi, Matthew,da Rosa, Joel Correa,et al. Overlapping Dopaminergic Pathway Genetic Susceptibility to Heroin and Cocaine Addictions in African Americans[J]. ANNALS OF HUMAN GENETICS,2015,79(3):188-198. |
| APA | Levran, Orna.,Randesi, Matthew.,da Rosa, Joel Correa.,Ott, Jurg.,Rotrosen, John.,...&Kreek, Mary Jeanne.(2015).Overlapping Dopaminergic Pathway Genetic Susceptibility to Heroin and Cocaine Addictions in African Americans.ANNALS OF HUMAN GENETICS,79(3),188-198. |
| MLA | Levran, Orna,et al."Overlapping Dopaminergic Pathway Genetic Susceptibility to Heroin and Cocaine Addictions in African Americans".ANNALS OF HUMAN GENETICS 79.3(2015):188-198. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| WOS_000353646400004.（427KB） | 期刊论文 | 出版稿 | 暂不开放 | CC BY-NC-SA | 请求全文 | |
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