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Overlapping Dopaminergic Pathway Genetic Susceptibility to Heroin and Cocaine Addictions in African Americans
Levran, Orna1; Randesi, Matthew1; da Rosa, Joel Correa2; Ott, Jurg3,4; Rotrosen, John5,6; Adelson, Miriam1,7; Kreek, Mary Jeanne1
2015-05-01
发表期刊ANNALS OF HUMAN GENETICS
ISSN0003-4800
文章类型Article
卷号79期号:3页码:188-198
摘要Drugs of abuse activate the mesolimbic dopaminergic pathway. Genetic variations in the dopaminergic system may contribute to drug addiction. Several processes are shared between cocaine and heroin addictions but some neurobiological mechanisms may be specific. This study examined the association of 98 single nucleotide polymorphisms in 13 dopamine-related genes with heroin addiction (OD) and/or cocaine addiction (CD) in a sample of 801 African Americans (315 subjects with OD +/- CD, 279 subjects with CD, and 207 controls). Single-marker analyses provided nominally significant evidence for associations of 24 SNPs) in DRD1, ANKK1/DRD2, DRD3, DRD5, DBH, DDC, COMT and CSNK1E. A DRD2 7-SNPs haplotype that includes SNPs rs1075650 and rs2283265, which were shown to alter D2S/D2L splicing, was indicated in both addictions. The Met allele of the functional COMT Val158Met was associated with protection from OD. None of the signals remained significant after correction for multiple testing. The study results are in accordance with the results of previous studies, including our report of association of DRD1 SNP rs5326 with OD. The findings suggest the presence of an overlap in genetic susceptibility for OD and CD, as well as shared and distinct susceptibility for OD in subjects of African and European descent.
关键词Dopaminergic pathway polymorphism heroin addiction cocaine addiction African Americans DRD1 DRD2 COMT Val158Met rs5326 rs1075650 rs2283265
收录类别SCI
语种英语
WOS记录号WOS:000353646400004
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13533
专题健康与遗传心理学研究室
作者单位1.Rockefeller Univ, Lab Biol Addict Dis, New York, NY 10065 USA
2.Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10065 USA
3.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
4.Rockefeller Univ, Lab Stat Genet, New York, NY 10065 USA
5.VA New York Harbor Healthcare Syst, New York, NY USA
6.NYU, Sch Med, New York, NY USA
7.Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, Las Vegas, NV USA
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Levran, Orna,Randesi, Matthew,da Rosa, Joel Correa,et al. Overlapping Dopaminergic Pathway Genetic Susceptibility to Heroin and Cocaine Addictions in African Americans[J]. ANNALS OF HUMAN GENETICS,2015,79(3):188-198.
APA Levran, Orna.,Randesi, Matthew.,da Rosa, Joel Correa.,Ott, Jurg.,Rotrosen, John.,...&Kreek, Mary Jeanne.(2015).Overlapping Dopaminergic Pathway Genetic Susceptibility to Heroin and Cocaine Addictions in African Americans.ANNALS OF HUMAN GENETICS,79(3),188-198.
MLA Levran, Orna,et al."Overlapping Dopaminergic Pathway Genetic Susceptibility to Heroin and Cocaine Addictions in African Americans".ANNALS OF HUMAN GENETICS 79.3(2015):188-198.
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