Superoxide Anion Regulates the Mitochondrial Free Ca2+ Through Uncoupling Proteins
Wu, Zhaofei1,2; Zhang, Jie3; Zhao, Baolu1,2,4,5
2009-08-01
发表期刊ANTIOXIDANTS & REDOX SIGNALING
ISSN1523-0864
文章类型Article
卷号11期号:8页码:1805-1818
摘要Mitochondrial dysfunction, which is closely related to intracellular calcium overload and excessive free radicals, is an important cause of Alzheimer's disease (AD). However, molecular mechanisms of the mitochondrial Ca2+ disregulation induced by oxidative stress in AD are still obscure. In an effort to gain a further understanding of this problem, we investigated the effects of superoxide anion, a primary free radical, on the expression of uncoupling proteins (UCPs) and the mitochondrial free Ca2+ levels in the neuroblastoma SH-SY5Y cell line (neo) and stably expressed wild-type human APP(APP) and APP-Swedish mutation (APPsw) SH-SY5Y cells. It was found that UCP2 and UCP4 protein levels were upregulated in neo but downregulated in APP and APPsw cells by the superoxide anion. Our results show that the superoxide anion can regulate protein levels of UCP2 and UCP4 in SH-SY5Y cells, and the mitochondrial free Ca2+ shifted their levels, tightly coupled with the protein levels of UCPs. When UCP2 and UCP4 were knocked down by siRNA, the result was reversed. These data suggest that the superoxide anion can regulate the mitochondrial free Ca2+ by regulating the expression of UCPs. These observations also indicate that UCPs can be potential targets in pathotherapy prevention of AD. Antioxid. Redox Signal. 11, 1805-1818.
收录类别SCI
语种英语
WOS记录号WOS:000267488900004
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13632
专题中国科学院心理研究所回溯数据库(1956-2010)
作者单位1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China
3.Rutgers State Univ, Dept Cell Biol & Neurosci, Piscataway, NJ USA
4.Chinese Acad Sci, Key Lab Mental Hlth, Beijing 100101, Peoples R China
5.Shanghai Univ Tradit Chinese Med, E Inst Shanghai Univ, Div Nitr Oxide & Inflammatory Med, Shanghai, Peoples R China
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Wu, Zhaofei,Zhang, Jie,Zhao, Baolu. Superoxide Anion Regulates the Mitochondrial Free Ca2+ Through Uncoupling Proteins[J]. ANTIOXIDANTS & REDOX SIGNALING,2009,11(8):1805-1818.
APA Wu, Zhaofei,Zhang, Jie,&Zhao, Baolu.(2009).Superoxide Anion Regulates the Mitochondrial Free Ca2+ Through Uncoupling Proteins.ANTIOXIDANTS & REDOX SIGNALING,11(8),1805-1818.
MLA Wu, Zhaofei,et al."Superoxide Anion Regulates the Mitochondrial Free Ca2+ Through Uncoupling Proteins".ANTIOXIDANTS & REDOX SIGNALING 11.8(2009):1805-1818.
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