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Superoxide Anion Regulates the Mitochondrial Free Ca2+ Through Uncoupling Proteins
Wu, Zhaofei1,2; Zhang, Jie3; Zhao, Baolu1,2,4,5
2009-08-01
Source PublicationANTIOXIDANTS & REDOX SIGNALING
ISSN1523-0864
SubtypeArticle
Volume11Issue:8Pages:1805-1818
AbstractMitochondrial dysfunction, which is closely related to intracellular calcium overload and excessive free radicals, is an important cause of Alzheimer's disease (AD). However, molecular mechanisms of the mitochondrial Ca2+ disregulation induced by oxidative stress in AD are still obscure. In an effort to gain a further understanding of this problem, we investigated the effects of superoxide anion, a primary free radical, on the expression of uncoupling proteins (UCPs) and the mitochondrial free Ca2+ levels in the neuroblastoma SH-SY5Y cell line (neo) and stably expressed wild-type human APP(APP) and APP-Swedish mutation (APPsw) SH-SY5Y cells. It was found that UCP2 and UCP4 protein levels were upregulated in neo but downregulated in APP and APPsw cells by the superoxide anion. Our results show that the superoxide anion can regulate protein levels of UCP2 and UCP4 in SH-SY5Y cells, and the mitochondrial free Ca2+ shifted their levels, tightly coupled with the protein levels of UCPs. When UCP2 and UCP4 were knocked down by siRNA, the result was reversed. These data suggest that the superoxide anion can regulate the mitochondrial free Ca2+ by regulating the expression of UCPs. These observations also indicate that UCPs can be potential targets in pathotherapy prevention of AD. Antioxid. Redox Signal. 11, 1805-1818.
Indexed BySCI
Language英语
WOS IDWOS:000267488900004
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13632
Collection中国科学院心理研究所回溯数据库(1956-2010)
Affiliation1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China
3.Rutgers State Univ, Dept Cell Biol & Neurosci, Piscataway, NJ USA
4.Chinese Acad Sci, Key Lab Mental Hlth, Beijing 100101, Peoples R China
5.Shanghai Univ Tradit Chinese Med, E Inst Shanghai Univ, Div Nitr Oxide & Inflammatory Med, Shanghai, Peoples R China
Recommended Citation
GB/T 7714
Wu, Zhaofei,Zhang, Jie,Zhao, Baolu. Superoxide Anion Regulates the Mitochondrial Free Ca2+ Through Uncoupling Proteins[J]. ANTIOXIDANTS & REDOX SIGNALING,2009,11(8):1805-1818.
APA Wu, Zhaofei,Zhang, Jie,&Zhao, Baolu.(2009).Superoxide Anion Regulates the Mitochondrial Free Ca2+ Through Uncoupling Proteins.ANTIOXIDANTS & REDOX SIGNALING,11(8),1805-1818.
MLA Wu, Zhaofei,et al."Superoxide Anion Regulates the Mitochondrial Free Ca2+ Through Uncoupling Proteins".ANTIOXIDANTS & REDOX SIGNALING 11.8(2009):1805-1818.
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