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Anticipatory pleasure predicts effective connectivity in the mesolimbic system
Liu, Zhi1,2; Yan, Chao3; Xie, Wei-Zhen4; Li, Ke5; Zeng, Ya-Wei5; Jin, Zhen5; Cheung, Eric F. C.6; Chan, Raymond C. K.1
2015-08-12
Source PublicationFRONTIERS IN BEHAVIORAL NEUROSCIENCE
ISSN1662-5153
SubtypeArticle
Volume9Issue:9Pages:217
AbstractConvergent evidence suggests the important role of the mesolimbic pathway in anticipating monetary rewards. However, the underlying mechanism of how the sub-regions interact with each other is still not clearly understood. Using dynamic causal modeling, we constructed a reward-related network for anticipating monetary reward using the Monetary Incentive Delay Task. Twenty-six healthy adolescents (Female/Male = 11/15; age = 18.69 +/- 1.35 years; education = 12 +/- 1.58 years) participated in the present study. The best-fit network involved the right substantia nigra/ventral tegmental area (SN/VTA), the right nucleus accumbens (NAcc) and the right thalamus, which were all activated during anticipation of monetary gain and loss. The SN/VTA directly activates the NAcc and the thalamus. More importantly, monetary gain modulated the connectivity from the SN/VTA to the NAcc and this was significantly correlated with subjective anticipatory pleasure (r = 0.649, p < 0.001). Our findings suggest that activity in the mesolimbic pathway during the anticipation of monetary reward could to some extent be predicted by subjective anticipatory pleasure.
Keywordhedonic capacity monetary reward dynamic causal modeling anticipatory pleasure
Indexed BySCI
Language英语
WOS IDWOS:000359603500001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13665
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.E China Normal Univ, Sch Psychol & Cognit Sci, Key Lab Brain Funct Genom MOE & STCSM, Shanghai 200062, Peoples R China
4.Univ Calif Riverside, Dept Psychol, Riverside, CA 92521 USA
5.Hosp 306 PLA, MRI Ctr, Beijing, Peoples R China
6.Castle Peak Hosp, Tuen Mun, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Liu, Zhi,Yan, Chao,Xie, Wei-Zhen,et al. Anticipatory pleasure predicts effective connectivity in the mesolimbic system[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2015,9(9):217.
APA Liu, Zhi.,Yan, Chao.,Xie, Wei-Zhen.,Li, Ke.,Zeng, Ya-Wei.,...&Chan, Raymond C. K..(2015).Anticipatory pleasure predicts effective connectivity in the mesolimbic system.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,9(9),217.
MLA Liu, Zhi,et al."Anticipatory pleasure predicts effective connectivity in the mesolimbic system".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 9.9(2015):217.
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