Malondialdehyde Suppresses Cerebral Function by Breaking Homeostasis between Excitation and Inhibition in Turtle Trachemys scripta

PSYCH OpenIR > 中国科学院心理研究所回溯数据库(1956-2010)

	Malondialdehyde Suppresses Cerebral Function by Breaking Homeostasis between Excitation and Inhibition in Turtle Trachemys scripta
	Li, Fangxu 1,2; Yang, Zhilai 1; Lu, Yang 1,4; Wei, Yan 1; Wang, Jinhui 1; Yin, Dazhong 2; He, Rongqiao 1,3
摘要	The levels of malondialdehyde (MDA) are high in the brain during carbonyl stress, such as following daily activities and sleep deprivation. To examine our hypothesis that MDA is one of the major substances in the brain leading to fatigue, the influences of MDA on brain functions and neuronal encodings in red-eared turtle (Trachemys scripta) were studied. The intrathecal injections of MDA brought about sleep-like EEG and fatigue-like behaviors in a dose-dependent manner. These changes were found associated with the deterioration of encoding action potentials in cortical neurons. In addition, MDA increased the ratio of gamma-aminobutyric acid to glutamate in turtle's brain, as well as the sensitivity of GABAergic neurons to inputs compared to excitatory neurons. Therefore, MDA, as a metabolic product in the brain, may weaken cerebral function during carbonyl stress through breaking the homeostasis between excitatory and inhibitory neurons.
	2010-12-22
语种	英语
发表期刊	PLOS ONE
ISSN	1932-6203
卷号	5 期号:12
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000285578000028
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/13676
专题	中国科学院心理研究所回溯数据库(1956-2010)
作者单位	1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100080, Peoples R China 2.Hunan Normal Univ, Coll Life Sci, Changsha, Hunan, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Lab Mental Hlth, Beijing 100080, Peoples R China 4.Univ Sci & Technol China, Hefei, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Li, Fangxu,Yang, Zhilai,Lu, Yang,et al. Malondialdehyde Suppresses Cerebral Function by Breaking Homeostasis between Excitation and Inhibition in Turtle Trachemys scripta[J]. PLOS ONE,2010,5(12).
APA	Li, Fangxu.,Yang, Zhilai.,Lu, Yang.,Wei, Yan.,Wang, Jinhui.,...&He, Rongqiao.(2010).Malondialdehyde Suppresses Cerebral Function by Breaking Homeostasis between Excitation and Inhibition in Turtle Trachemys scripta.PLOS ONE,5(12).
MLA	Li, Fangxu,et al."Malondialdehyde Suppresses Cerebral Function by Breaking Homeostasis between Excitation and Inhibition in Turtle Trachemys scripta".PLOS ONE 5.12(2010).