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Malondialdehyde Suppresses Cerebral Function by Breaking Homeostasis between Excitation and Inhibition in Turtle Trachemys scripta
Li, Fangxu1,2; Yang, Zhilai1; Lu, Yang1,4; Wei, Yan1; Wang, Jinhui1; Yin, Dazhong2; He, Rongqiao1,3
2010-12-22
Source PublicationPLOS ONE
ISSN1932-6203
SubtypeArticle
Volume5Issue:12
AbstractThe levels of malondialdehyde (MDA) are high in the brain during carbonyl stress, such as following daily activities and sleep deprivation. To examine our hypothesis that MDA is one of the major substances in the brain leading to fatigue, the influences of MDA on brain functions and neuronal encodings in red-eared turtle (Trachemys scripta) were studied. The intrathecal injections of MDA brought about sleep-like EEG and fatigue-like behaviors in a dose-dependent manner. These changes were found associated with the deterioration of encoding action potentials in cortical neurons. In addition, MDA increased the ratio of gamma-aminobutyric acid to glutamate in turtle's brain, as well as the sensitivity of GABAergic neurons to inputs compared to excitatory neurons. Therefore, MDA, as a metabolic product in the brain, may weaken cerebral function during carbonyl stress through breaking the homeostasis between excitatory and inhibitory neurons.
Indexed BySCI
Language英语
WOS IDWOS:000285578000028
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13676
Collection中国科学院心理研究所回溯数据库(1956-2010)
Affiliation1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100080, Peoples R China
2.Hunan Normal Univ, Coll Life Sci, Changsha, Hunan, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Lab Mental Hlth, Beijing 100080, Peoples R China
4.Univ Sci & Technol China, Hefei, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Li, Fangxu,Yang, Zhilai,Lu, Yang,et al. Malondialdehyde Suppresses Cerebral Function by Breaking Homeostasis between Excitation and Inhibition in Turtle Trachemys scripta[J]. PLOS ONE,2010,5(12).
APA Li, Fangxu.,Yang, Zhilai.,Lu, Yang.,Wei, Yan.,Wang, Jinhui.,...&He, Rongqiao.(2010).Malondialdehyde Suppresses Cerebral Function by Breaking Homeostasis between Excitation and Inhibition in Turtle Trachemys scripta.PLOS ONE,5(12).
MLA Li, Fangxu,et al."Malondialdehyde Suppresses Cerebral Function by Breaking Homeostasis between Excitation and Inhibition in Turtle Trachemys scripta".PLOS ONE 5.12(2010).
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