Malondialdehyde Suppresses Cerebral Function by Breaking Homeostasis between Excitation and Inhibition in Turtle Trachemys scripta
Li, Fangxu1,2; Yang, Zhilai1; Lu, Yang1,4; Wei, Yan1; Wang, Jinhui1; Yin, Dazhong2; He, Rongqiao1,3
2010-12-22
发表期刊PLOS ONE
ISSN1932-6203
文章类型Article
卷号5期号:12
摘要The levels of malondialdehyde (MDA) are high in the brain during carbonyl stress, such as following daily activities and sleep deprivation. To examine our hypothesis that MDA is one of the major substances in the brain leading to fatigue, the influences of MDA on brain functions and neuronal encodings in red-eared turtle (Trachemys scripta) were studied. The intrathecal injections of MDA brought about sleep-like EEG and fatigue-like behaviors in a dose-dependent manner. These changes were found associated with the deterioration of encoding action potentials in cortical neurons. In addition, MDA increased the ratio of gamma-aminobutyric acid to glutamate in turtle's brain, as well as the sensitivity of GABAergic neurons to inputs compared to excitatory neurons. Therefore, MDA, as a metabolic product in the brain, may weaken cerebral function during carbonyl stress through breaking the homeostasis between excitatory and inhibitory neurons.
收录类别SCI
语种英语
WOS记录号WOS:000285578000028
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13676
专题中国科学院心理研究所回溯数据库(1956-2010)
作者单位1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100080, Peoples R China
2.Hunan Normal Univ, Coll Life Sci, Changsha, Hunan, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Lab Mental Hlth, Beijing 100080, Peoples R China
4.Univ Sci & Technol China, Hefei, Anhui, Peoples R China
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Li, Fangxu,Yang, Zhilai,Lu, Yang,et al. Malondialdehyde Suppresses Cerebral Function by Breaking Homeostasis between Excitation and Inhibition in Turtle Trachemys scripta[J]. PLOS ONE,2010,5(12).
APA Li, Fangxu.,Yang, Zhilai.,Lu, Yang.,Wei, Yan.,Wang, Jinhui.,...&He, Rongqiao.(2010).Malondialdehyde Suppresses Cerebral Function by Breaking Homeostasis between Excitation and Inhibition in Turtle Trachemys scripta.PLOS ONE,5(12).
MLA Li, Fangxu,et al."Malondialdehyde Suppresses Cerebral Function by Breaking Homeostasis between Excitation and Inhibition in Turtle Trachemys scripta".PLOS ONE 5.12(2010).
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