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Alterations in the processing of no n-drug-related affective stimuli in abstinent heroin addicts
Wang, Zhao-Xin1; Zhang, John X.2; Wu, Qiu-Lin1; Liu, Ning3; Hu, Xiao-Ping4,5; chan, Raymond C. K.6; Xiao, Zhuang-Wei1
Source PublicationNEUROIMAGE
Contribution Rank6
AbstractLong-term exposure to drug may alter the neural system associated with affective processing, as evidenced by both clinical observations and behavioral data documenting dysfunctions in emotional experiences and processing in drug addicts. Although many imaging studies examined neural responses to drug or drug-related cues in addicts, there have been few studies explicitly designed to reveal their neural abnormalities in processing non-drug-related natural affective materials. The present study asked abstinent heroin addicts and normal controls to passively view standardized affective pictures of positive, negative, or neutral valence and compared their brain activities with functional MRI. Compared to normal controls, addicts showed reduced activation in right amygdala in response to the affective pictures, consistent with previous reports of blunted subjective experience for affective stimuli in addicts. Furthermore, in two visual cortical areas BA 19 and 37, while the controls showed greater responses to positive pictures than to negative ones replicating literature findings, the addicts showed the opposite pattern. The results reveal a complex pattern of altered processing of non-drug-related affected materials in addicts showing both heightened and blunted neural responses in different brain regions and for different stimulus valence. The present study highlights the importance of brain imaging research on drug addicts' processing of affective stimuli in understanding disruptions in their emotion circuitry. (C) 2009 Elsevier Inc. All rights reserved.
KeywordAddiction Heroin Affective processing Emotion Amygdala Visual cortex
Subject Area生理心理学/生物心理学
Indexed BySCI
WOS IDWOS:000272031700097
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorXiao, Zhuang-Wei
Affiliation1.Chinese Univ Hong Kong, Dept Psychol, Shatin, Hong Kong, Peoples R China
2.Shantou Univ, Coll Med, Affiliated Hosp 1, Guangdong Key Lab Med Mol Imaging, Shantou, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Kunming, Peoples R China
4.Georgia Inst Technol, Dept Biomed Engn, Atlanta, GA 30332 USA
5.Emory Univ, Atlanta, GA 30322 USA
6.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Wang, Zhao-Xin,Zhang, John X.,Wu, Qiu-Lin,et al. Alterations in the processing of no n-drug-related affective stimuli in abstinent heroin addicts[J]. NEUROIMAGE,2010,49(1):971-976.
APA Wang, Zhao-Xin.,Zhang, John X..,Wu, Qiu-Lin.,Liu, Ning.,Hu, Xiao-Ping.,...&Xiao, Zhuang-Wei.(2010).Alterations in the processing of no n-drug-related affective stimuli in abstinent heroin addicts.NEUROIMAGE,49(1),971-976.
MLA Wang, Zhao-Xin,et al."Alterations in the processing of no n-drug-related affective stimuli in abstinent heroin addicts".NEUROIMAGE 49.1(2010):971-976.
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