Executive control in schizophrenia in task involving semantic inhibition and working memory
Chan, Raymond C. K.1,2,3; Huang, Jia3,4; Guo, Lan5; Cao, Xiaoyan1,2,6; Hong, Xiaohong7; Gao, Zhan8
2010-10-30
发表期刊PSYCHIATRY RESEARCH
ISSN0165-1781
文章类型Article
卷号179期号:3页码:259-266
摘要Executive dysfunctions have been consistently demonstrated in patients with schizophrenia. This study aimed to investigate deficits in specific executive functioning components, namely working memory and inhibition, in schizophrenia. In study 1, a set of neurocognitive function tests was administered to 41 patients with schizophrenia and 25 healthy controls to capture specific components of executive functioning, including semantic inhibition (the Stroop-like paradigm and the Chinese Version of the Hayling Sentence Completion Test (HSC)), working memory (the spatial n-back), and response inhibition (the stop signal task (SST)). Results showed that schizophrenia patients did significantly worse than controls under both working memory and inhibition demands in the Stroop-like paradigm. In particular, patients were impaired when inhibiting a semantically associated response; and performance was correlated with negative symptoms. In study 2, we employed a modified semantic inhibitory error monitoring paradigm to examine whether patients with schizophrenia (n = 11) were impaired in semantic inhibitory error monitoring or not as compared to 11 healthy controls. The results suggested that patients with schizophrenia in this study remained intact in semantic inhibition error monitoring. There was no difference in the semantic inhibitory monitoring performance between healthy controls and patients with schizophrenia. Taken together, these results suggested impaired working memory context maintenance and semantic inhibition in schizophrenia patients, and these impairments were related to clinical symptoms of schizophrenia. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
关键词Executive function Working memory Error monitoring Schizophrenia Semantic inhibition
收录类别SCI ; SSCI
语种英语
WOS记录号WOS:000283897300004
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13682
专题中国科学院心理研究所回溯数据库(1956-2010)
作者单位1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Sun Yat Sen Univ, Dept Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Guangzhou 510275, Guangdong, Peoples R China
4.Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China
5.Dartmouth Med Sch, Dept Physiol, Lebanon, NH USA
6.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China
7.Shantou Univ, Coll Med, Mental Hlth Ctr, Shantou, Peoples R China
8.Dispensary Chron Dis Zhuhai, Zhuhai, Peoples R China
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Chan, Raymond C. K.,Huang, Jia,Guo, Lan,et al. Executive control in schizophrenia in task involving semantic inhibition and working memory[J]. PSYCHIATRY RESEARCH,2010,179(3):259-266.
APA Chan, Raymond C. K.,Huang, Jia,Guo, Lan,Cao, Xiaoyan,Hong, Xiaohong,&Gao, Zhan.(2010).Executive control in schizophrenia in task involving semantic inhibition and working memory.PSYCHIATRY RESEARCH,179(3),259-266.
MLA Chan, Raymond C. K.,et al."Executive control in schizophrenia in task involving semantic inhibition and working memory".PSYCHIATRY RESEARCH 179.3(2010):259-266.
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