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Cinnamaldehyde up-regulates the mRNA expression level of TRPV1 receptor potential ion channel protein and its function in primary rat DRG neurons in vitro
Sui, Feng1; Lin, Na1; Guo, Jian-You2; Zhang, Chang-Bin3; Du, Xin-Liang1; Zhao, Bao-Sheng1; Liu, Hong-Bin1; Yang, Na1; Li, Lan-Fang1; Guo, Shu-Ying1; Huo, Hai-Ru1; Jiang, Ting-Liang1; Hai-Ru Huo
2010
Source PublicationJOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Correspondent Emailhuohr@yahoo.com.cn
ISSN1028-6020
SubtypeArticle
Volume12Issue:1Pages:76-87
Contribution Rank2
AbstractCinnamaldehyde (1) is a pharmacologically active ingredient isolated from cassia twig (Ramulus Cinnamomi), which is commonly used in herbal remedies to treat fever-related diseases. Both TRPV1 and TRPM8 ion channel proteins are abundantly expressed in sensory neurons, and are assumed to act as a thermosensor, with the former mediating the feeling of warmth and the latter the feeling of cold in the body. Both of them have recently been reported to be involved in thermoregulation. The purpose of this paper is to further uncover the antipyretic mechanisms of 1 by investigating its effects on the mRNA expression levels and functions of both TRPV1 and TRPM8. The results showed that 1 could up-regulate the mRNA expression levels of TRPV1 at both 37 and 39 degrees C, and its calcium-mediating function was significantly increased at 39 degrees C, all of which could not be blocked by pretreatment of the neuronal cells with ruthenium red, a general transient receptor potential (TRP) blocker, indicating that the action of 1 was achieved through a non-TRPA1 channel pathway. In conclusion, the findings in our in vitro studies might account for part of the peripheral molecular mechanisms for the antipyretic action of 1.
Keywordcinnamaldehyde TRPV1 TRPM8 DRG capsaicin menthol
Subject Area生理心理学/生物心理学
Indexed BySCI
Language英语
WOS IDWOS:000277569700012
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13685
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorHai-Ru Huo
Affiliation1.China Acad Chinese Med Sci, Inst Chinese Mat Med, Tang Ctr Herbal Med Res, Beijing 100700, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Nanjing Univ Chinese Med, Nanjing 210046, Peoples R China
Recommended Citation
GB/T 7714
Sui, Feng,Lin, Na,Guo, Jian-You,et al. Cinnamaldehyde up-regulates the mRNA expression level of TRPV1 receptor potential ion channel protein and its function in primary rat DRG neurons in vitro[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2010,12(1):76-87.
APA Sui, Feng.,Lin, Na.,Guo, Jian-You.,Zhang, Chang-Bin.,Du, Xin-Liang.,...&Hai-Ru Huo.(2010).Cinnamaldehyde up-regulates the mRNA expression level of TRPV1 receptor potential ion channel protein and its function in primary rat DRG neurons in vitro.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,12(1),76-87.
MLA Sui, Feng,et al."Cinnamaldehyde up-regulates the mRNA expression level of TRPV1 receptor potential ion channel protein and its function in primary rat DRG neurons in vitro".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 12.1(2010):76-87.
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