Cinnamaldehyde up-regulates the mRNA expression level of TRPV1 receptor potential ion channel protein and its function in primary rat DRG neurons in vitro
Sui, Feng1; Lin, Na1; Guo, Jian-You2; Zhang, Chang-Bin3; Du, Xin-Liang1; Zhao, Bao-Sheng1; Liu, Hong-Bin1; Yang, Na1; Li, Lan-Fang1; Guo, Shu-Ying1; Huo, Hai-Ru1; Jiang, Ting-Liang1; Hai-Ru Huo
2010
发表期刊JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
通讯作者邮箱huohr@yahoo.com.cn
ISSN1028-6020
文章类型Article
卷号12期号:1页码:76-87
产权排序2
摘要Cinnamaldehyde (1) is a pharmacologically active ingredient isolated from cassia twig (Ramulus Cinnamomi), which is commonly used in herbal remedies to treat fever-related diseases. Both TRPV1 and TRPM8 ion channel proteins are abundantly expressed in sensory neurons, and are assumed to act as a thermosensor, with the former mediating the feeling of warmth and the latter the feeling of cold in the body. Both of them have recently been reported to be involved in thermoregulation. The purpose of this paper is to further uncover the antipyretic mechanisms of 1 by investigating its effects on the mRNA expression levels and functions of both TRPV1 and TRPM8. The results showed that 1 could up-regulate the mRNA expression levels of TRPV1 at both 37 and 39 degrees C, and its calcium-mediating function was significantly increased at 39 degrees C, all of which could not be blocked by pretreatment of the neuronal cells with ruthenium red, a general transient receptor potential (TRP) blocker, indicating that the action of 1 was achieved through a non-TRPA1 channel pathway. In conclusion, the findings in our in vitro studies might account for part of the peripheral molecular mechanisms for the antipyretic action of 1.
关键词cinnamaldehyde TRPV1 TRPM8 DRG capsaicin menthol
学科领域生理心理学/生物心理学
收录类别SCI
语种英语
WOS记录号WOS:000277569700012
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13685
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Hai-Ru Huo
作者单位1.China Acad Chinese Med Sci, Inst Chinese Mat Med, Tang Ctr Herbal Med Res, Beijing 100700, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Nanjing Univ Chinese Med, Nanjing 210046, Peoples R China
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Sui, Feng,Lin, Na,Guo, Jian-You,et al. Cinnamaldehyde up-regulates the mRNA expression level of TRPV1 receptor potential ion channel protein and its function in primary rat DRG neurons in vitro[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2010,12(1):76-87.
APA Sui, Feng.,Lin, Na.,Guo, Jian-You.,Zhang, Chang-Bin.,Du, Xin-Liang.,...&Hai-Ru Huo.(2010).Cinnamaldehyde up-regulates the mRNA expression level of TRPV1 receptor potential ion channel protein and its function in primary rat DRG neurons in vitro.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,12(1),76-87.
MLA Sui, Feng,et al."Cinnamaldehyde up-regulates the mRNA expression level of TRPV1 receptor potential ion channel protein and its function in primary rat DRG neurons in vitro".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 12.1(2010):76-87.
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