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High-Frequency Stimulation of the Subthalamic Nucleus Restores Neural and Behavioral Functions During Reaction Time Task in a Rat Model of Parkinson's Disease
Li, Xiang-Hong2; Wang, Jin-Yan1; Gao, Ge1; Chang, Jing-Yu3; Woodward, Donald J.3; Luo, Fei1,2; Fei Luo
2010-05-15
Source PublicationJOURNAL OF NEUROSCIENCE RESEARCH
Correspondent Emailluof@psych.ac.cn
ISSN0360-4012
SubtypeArticle
Volume88Issue:7Pages:1510-1521
Contribution Rank1
AbstractDeep brain stimulation (DBS) has been used in the clinic to treat Parkinson's disease (PD) and other neuropsychiatric disorders. Our previous work has shown that DBS in the subthalamic nucleus (STN) can improve major motor deficits, and induce a variety of neural responses in rats with unilateral dopamine (DA) lesions. In the present study, we examined the effect of STN DBS on reaction time (RT) performance and parallel changes in neural activity in the cortico-basal ganglia regions of partially bilateral DA- lesioned rats. We recorded neural activity with a multiple-channel single-unit electrode system in the primary motor cortex (MI), the STN, and the substantia nigra pars reticulata (SNr) during RT test. RT performance was severely impaired following bilateral injection of 6-OHDA into the dorsolateral part of the striatum. In parallel with such behavioral impairments, the number of responsive neurons to different behavioral events was remarkably decreased after DA lesion. Bilateral STN DBS improved RT performance in 6-OHDA lesioned rats, and restored operational behavior-related neural responses in cortico-basal ganglia regions. These behavioral and electrophysiological effects of DBS lasted nearly an hour after DBS termination. These results demonstrate that a partial DA lesion-induced impairment of RT performance is associated with changes in neural activity in the cortico-basal ganglia circuit. Furthermore, STN DBS can reverse changes in behavior and neural activity caused by partial DA depletion. The observed long-lasting beneficial effect of STN DBS suggests the involvement of the mechanism of neural plasticity in modulating corticobasal ganglia circuits. (C) 2009 Wiley-Liss, Inc.
Keyworddeep brain stimulation electrophysiology striatum motor cortex single-unit recording
Subject Area生理心理学/生物心理学
Indexed BySCI
Language英语
WOS IDWOS:000276858600011
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13692
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorFei Luo
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
2.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China
3.Neurosci Res Inst N Carolina, Winston Salem, NC USA
Recommended Citation
GB/T 7714
Li, Xiang-Hong,Wang, Jin-Yan,Gao, Ge,et al. High-Frequency Stimulation of the Subthalamic Nucleus Restores Neural and Behavioral Functions During Reaction Time Task in a Rat Model of Parkinson's Disease[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2010,88(7):1510-1521.
APA Li, Xiang-Hong.,Wang, Jin-Yan.,Gao, Ge.,Chang, Jing-Yu.,Woodward, Donald J..,...&Fei Luo.(2010).High-Frequency Stimulation of the Subthalamic Nucleus Restores Neural and Behavioral Functions During Reaction Time Task in a Rat Model of Parkinson's Disease.JOURNAL OF NEUROSCIENCE RESEARCH,88(7),1510-1521.
MLA Li, Xiang-Hong,et al."High-Frequency Stimulation of the Subthalamic Nucleus Restores Neural and Behavioral Functions During Reaction Time Task in a Rat Model of Parkinson's Disease".JOURNAL OF NEUROSCIENCE RESEARCH 88.7(2010):1510-1521.
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