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Surface-Based Regional Homogeneity in First-Episode, Drug-Naive Major Depression: A Resting-State fMRI Study
Li, Hui-Jie1; Cao, Xiao-Hua2; Zhu, Xing-Ting1,3; Zhang, Ai-Xia2; Hou, Xiao-Hui1,3; Xu, Yong2; Zuo, Xi-Nian1; Zhang, Ke-Rang2
2014
Source PublicationBIOMED RESEARCH INTERNATIONAL
ISSN2314-6133
SubtypeArticle
Volume2014Issue:0Pages:1-8
AbstractBackground. Previous volume-based regional homogeneity (ReHo) studies neglected the intersubject variability in cortical folding patterns. Recently, surface-based ReHo was developed to reduce the intersubject variability and to increase statistical power. The present study used this novel surface-based ReHo approach to explore the brain functional activity differences between first-episode, drug-naive MDD patients and healthy controls. Methods. Thirty-three first-episode, drug-naive MDD patients and 32 healthy controls participated in structural and resting-state fMRI scans. MDD patients were rated with a 17-item Hamilton Rating Scale for Depression prior to the scan. Results. In comparison with the healthy controls, MDD patients showed reduced surface-based ReHo in the left insula. There was no increase in surface-based ReHo in MDD patients. The surface-based ReHo value in the left insula was not significantly correlated with the clinical information or the depressive scores in the MDD group. Conclusions. The decreased surface-based ReHo in the left insula in MDD may lead to the abnormal top-down cortical-limbic regulation of emotional and cognitive information. The surface-based ReHo may be a useful index to explore the pathophysiological mechanism of MDD.
Indexed BySCI
Language英语
WOS IDWOS:000332642300001
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13724
Collection中国科学院行为科学重点实验室
Affiliation1.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Lab Funct Connectome & Dev, Key Lab Behav Sci,Inst Psychol, Beijing 100101, Peoples R China
2.Shanxi Med Univ, Hosp 1, Dept Psychiat, Taiyuan 030001, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Hui-Jie,Cao, Xiao-Hua,Zhu, Xing-Ting,et al. Surface-Based Regional Homogeneity in First-Episode, Drug-Naive Major Depression: A Resting-State fMRI Study[J]. BIOMED RESEARCH INTERNATIONAL,2014,2014(0):1-8.
APA Li, Hui-Jie.,Cao, Xiao-Hua.,Zhu, Xing-Ting.,Zhang, Ai-Xia.,Hou, Xiao-Hui.,...&Zhang, Ke-Rang.(2014).Surface-Based Regional Homogeneity in First-Episode, Drug-Naive Major Depression: A Resting-State fMRI Study.BIOMED RESEARCH INTERNATIONAL,2014(0),1-8.
MLA Li, Hui-Jie,et al."Surface-Based Regional Homogeneity in First-Episode, Drug-Naive Major Depression: A Resting-State fMRI Study".BIOMED RESEARCH INTERNATIONAL 2014.0(2014):1-8.
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