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Intervention-induced enhancement in intrinsic brain activity in healthy older adults
Yin, Shufei1,2; Zhu, Xinyi1; Li, Rui1,3; Niu, Yanan1; Wang, Baoxi1,2; Zheng, Zhiwei1,2; Huang, Xin1,2; Huo, Lijuan1,2; Li, Juan1,3
AbstractThis study examined the effects of a multimodal intervention on spontaneous brain activity in healthy older adults. Seventeen older adults received a six-week intervention that consisted of cognitive training, Tai Chi exercise, and group counseling, while 17 older adults in a control group attended health knowledge lectures. The intervention group demonstrated enhanced memory and social support compared to the control group. The amplitude of low frequency fluctuations (ALFF) in the middle frontal gyrus, superior frontal gyrus, and anterior cerebellum lobe was enhanced for the intervention group, while the control group showed reduced ALFF in these three regions. Moreover, changes in trail-making performance and well-being could be predicted by the intervention-induced changes in ALFF. Additionally, individual differences in the baseline ALFF were correlated with intervention-related changes in behavioral performance. These findings suggest that a multimodal intervention is effective in improving cognitive functions and well-being and can induce functional changes in the aging brain. The study extended previous training studies by suggesting resting-state ALFF as a marker of intervention-induced plasticity in older adults.
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WOS IDWOS:000346267700003
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Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Chinese Acad Sci, Inst Psychol, Ctr Aging Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Yin, Shufei,Zhu, Xinyi,Li, Rui,et al. Intervention-induced enhancement in intrinsic brain activity in healthy older adults[J]. SCIENTIFIC REPORTS,2014,4(0):7309.
APA Yin, Shufei.,Zhu, Xinyi.,Li, Rui.,Niu, Yanan.,Wang, Baoxi.,...&Li, Juan.(2014).Intervention-induced enhancement in intrinsic brain activity in healthy older adults.SCIENTIFIC REPORTS,4(0),7309.
MLA Yin, Shufei,et al."Intervention-induced enhancement in intrinsic brain activity in healthy older adults".SCIENTIFIC REPORTS 4.0(2014):7309.
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