Topological organization of the human brain functional connectome across the lifespan

	Topological organization of the human brain functional connectome across the lifespan
	Cao, Miao 1,10; Wang, Jin-Hui 1,3,4; Dai, Zheng-Jia 1,10; Cao, Xiao-Yan2,3,4 ; Jiang, Li-Li2 ; Fan, Feng-Mei 2,5; Song, Xiao-Wei 6; Xia, Ming-Rui 1,10; Shu, Ni 1,10; Dong, Qi 1,10; Milham, Michael P.7,8; Castellanos, F. Xavier 8,9; Zuo, Xi-Nian2,10 ; He, Yong 1,10
摘要	Human brain function undergoes complex transformations across the lifespan. We employed resting-state functional MRI and graph-theory approaches to systematically chart the lifespan trajectory of the topological organization of human whole-brain functional networks in 126 healthy individuals ranging in age from 7 to 85 years. Brain networks were constructed by computing Pearson's correlations in blood-oxygenation-level-dependent temporal fluctuations among 1024 parcellation units followed by graph-based network analyses. We observed that the human brain functional connectome exhibited highly preserved non-random modular and rich club organization over the entire age range studied. Further quantitative analyses revealed linear decreases in modularity and inverted-U shaped trajectories of local efficiency and rich club architecture. Regionally heterogeneous age effects were mainly located in several hubs (e.g., default network, dorsal attention regions). Finally, we observed inverse trajectories of long- and short-distance functional connections, indicating that the reorganization of connectivity concentrates and distributes the brain's functional networks. Our results demonstrate topological changes in the whole-brain functional connectome across nearly the entire human lifespan, providing insights into the neural substrates Underlying individual variations in behavior and cognition. These results have important implications for disease connectomics because they provide a baseline for evaluating network impairments in age-related neuropsychiatric disorders. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
关键词	Functional connectomics Lifespan trajectory Rich club Graph theory
	2014
语种	英语
发表期刊	DEVELOPMENTAL COGNITIVE NEUROSCIENCE
ISSN	1878-9293
卷号	7 期号:0 页码:76-93
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000330147200008
引用统计	被引频次：307[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/13731
专题	中国科学院行为科学重点实验室
作者单位	1.Beijing Normal Univ, State Key Lab Cognit Neurosci, Learning & Int Data Grp, McGovern Inst Brain Res, Beijing 100875, Peoples R China 2.Chinese Acad Sci, Key Lab Behav Sci, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China 3.Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Hangzhou 310015, Zhejiang, Peoples R China 4.Zhejiang Key Lab Res Assessment Cognit Impairment, Hangzhou 310015, Zhejiang, Peoples R China 5.Beijing Huilongguan Hosp, Psychiat Res Ctr, Beijing 100096, Peoples R China 6.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China 7.Child Mind Inst, Ctr Developing Brain, New York, NY 10022 USA 8.Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA 9.NYU, Langone Med Ctr, Phyllis Green & Randolph Cowen Inst Pediat Neuros, New York, NY 10016 USA 10.Beijing Normal Univ, Ctr Collaborat & Innovat Brain & Learning Sci, Beijing 100875, Peoples R China
推荐引用方式 GB/T 7714	Cao, Miao,Wang, Jin-Hui,Dai, Zheng-Jia,et al. Topological organization of the human brain functional connectome across the lifespan[J]. DEVELOPMENTAL COGNITIVE NEUROSCIENCE,2014,7(0):76-93.
APA	Cao, Miao.,Wang, Jin-Hui.,Dai, Zheng-Jia.,Cao, Xiao-Yan.,Jiang, Li-Li.,...&He, Yong.(2014).Topological organization of the human brain functional connectome across the lifespan.DEVELOPMENTAL COGNITIVE NEUROSCIENCE,7(0),76-93.
MLA	Cao, Miao,et al."Topological organization of the human brain functional connectome across the lifespan".DEVELOPMENTAL COGNITIVE NEUROSCIENCE 7.0(2014):76-93.

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