PSYCH OpenIR  > 中国科学院行为科学重点实验室
Topological organization of the human brain functional connectome across the lifespan
Cao, Miao1,10; Wang, Jin-Hui1,3,4; Dai, Zheng-Jia1,10; Cao, Xiao-Yan2,3,4; Jiang, Li-Li2; Fan, Feng-Mei2,5; Song, Xiao-Wei6; Xia, Ming-Rui1,10; Shu, Ni1,10; Dong, Qi1,10; Milham, Michael P.7,8; Castellanos, F. Xavier8,9; Zuo, Xi-Nian2,10; He, Yong1,10
2014
Source PublicationDEVELOPMENTAL COGNITIVE NEUROSCIENCE
ISSN1878-9293
SubtypeArticle
Volume7Issue:0Pages:76-93
AbstractHuman brain function undergoes complex transformations across the lifespan. We employed resting-state functional MRI and graph-theory approaches to systematically chart the lifespan trajectory of the topological organization of human whole-brain functional networks in 126 healthy individuals ranging in age from 7 to 85 years. Brain networks were constructed by computing Pearson's correlations in blood-oxygenation-level-dependent temporal fluctuations among 1024 parcellation units followed by graph-based network analyses. We observed that the human brain functional connectome exhibited highly preserved non-random modular and rich club organization over the entire age range studied. Further quantitative analyses revealed linear decreases in modularity and inverted-U shaped trajectories of local efficiency and rich club architecture. Regionally heterogeneous age effects were mainly located in several hubs (e.g., default network, dorsal attention regions). Finally, we observed inverse trajectories of long- and short-distance functional connections, indicating that the reorganization of connectivity concentrates and distributes the brain's functional networks. Our results demonstrate topological changes in the whole-brain functional connectome across nearly the entire human lifespan, providing insights into the neural substrates Underlying individual variations in behavior and cognition. These results have important implications for disease connectomics because they provide a baseline for evaluating network impairments in age-related neuropsychiatric disorders. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
KeywordFunctional connectomics Lifespan trajectory Rich club Graph theory
Indexed BySCI
Language英语
WOS IDWOS:000330147200008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13731
Collection中国科学院行为科学重点实验室
Affiliation1.Beijing Normal Univ, State Key Lab Cognit Neurosci, Learning & Int Data Grp, McGovern Inst Brain Res, Beijing 100875, Peoples R China
2.Chinese Acad Sci, Key Lab Behav Sci, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
3.Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Hangzhou 310015, Zhejiang, Peoples R China
4.Zhejiang Key Lab Res Assessment Cognit Impairment, Hangzhou 310015, Zhejiang, Peoples R China
5.Beijing Huilongguan Hosp, Psychiat Res Ctr, Beijing 100096, Peoples R China
6.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China
7.Child Mind Inst, Ctr Developing Brain, New York, NY 10022 USA
8.Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA
9.NYU, Langone Med Ctr, Phyllis Green & Randolph Cowen Inst Pediat Neuros, New York, NY 10016 USA
10.Beijing Normal Univ, Ctr Collaborat & Innovat Brain & Learning Sci, Beijing 100875, Peoples R China
Recommended Citation
GB/T 7714
Cao, Miao,Wang, Jin-Hui,Dai, Zheng-Jia,et al. Topological organization of the human brain functional connectome across the lifespan[J]. DEVELOPMENTAL COGNITIVE NEUROSCIENCE,2014,7(0):76-93.
APA Cao, Miao.,Wang, Jin-Hui.,Dai, Zheng-Jia.,Cao, Xiao-Yan.,Jiang, Li-Li.,...&He, Yong.(2014).Topological organization of the human brain functional connectome across the lifespan.DEVELOPMENTAL COGNITIVE NEUROSCIENCE,7(0),76-93.
MLA Cao, Miao,et al."Topological organization of the human brain functional connectome across the lifespan".DEVELOPMENTAL COGNITIVE NEUROSCIENCE 7.0(2014):76-93.
Files in This Item:
File Name/Size DocType Version Access License
WOS_000330147200008.(4203KB)期刊论文出版稿暂不开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Cao, Miao]'s Articles
[Wang, Jin-Hui]'s Articles
[Dai, Zheng-Jia]'s Articles
Baidu academic
Similar articles in Baidu academic
[Cao, Miao]'s Articles
[Wang, Jin-Hui]'s Articles
[Dai, Zheng-Jia]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Cao, Miao]'s Articles
[Wang, Jin-Hui]'s Articles
[Dai, Zheng-Jia]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.