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The ENPP1 K121Q polymorphism is not associated with type 2 diabetes in northern Chinese
Shi, Xiaohong1; Wang, Li2; Jin, Feng3; Sun, Junfeng1; Sun, Liang1; Tang, Lei1; Yang, Ze1; Shi, XH (reprint author), Beijing Hosp, Key Lab Geriatr, Inst Geriatr, Minist Hlth, Beijing 100730, Peoples R China.
2011-12-01
发表期刊ACTA DIABETOLOGICA
ISSN0940-5429
文章类型Article
卷号48期号:4页码:303-310
产权排序3
摘要The K121Q polymorphism of the ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) gene has been studied in relation to insulin resistance, type 2 diabetes, and obesity, and conflicting results were observed in various populations. The purpose of the present study was to investigate the prevalence of K121Q polymorphism of ENPP1 gene and to clarify whether this polymorphism is associated with type 2 diabetes susceptibility in northern Chinese population. We studied the association of the ENPP1 K121Q polymorphism with type 2 diabetes (T2D) in 639 unrelated patients and 885 control subjects with normal glucose tolerance of northern China. The patients were diagnosed in accordance with the guidelines of the American Diabetes Association (ADA). Genotypes were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The distribution of KK, KQ, and QQ genotypes among patients was 79.5, 19.2, and 1.3%, similar to that of the control group (79.2, 20.1, and 0.7%). After readjusting for the confounding effects of age, gender, and BMI, no significant effect of genotypes on T2D was found for any of the genetic models tested (recessive model, dominant model, or additive model). All clinical characteristics tested were similar among the different genotypes, and no significant associations were observed both in T2D patients and in controls. When subgroup analyses of T2D patients and non-diabetic controls were stratified according to BMI and waist circumference, the variant was still not associated with T2D. The results showed that the ENPP1 K121Q polymorphism is not associated with genetic susceptibility of type 2 diabetes in the northern Chinese population.
关键词ENPP1 Type 2 diabetes Polymorphism Northern Chinese
学科领域Medical Psychology
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收录类别SCI
语种英语
项目资助者Major State Basic Research Development Program of China (973 Program) [2006CB503901] ; National High Technology Research and Development program of China (863 program) [2002AA223031] ; National Natural Science Foundation of China [30972709, 81061120527]
项目简介This research was supported by the grants from the Major State Basic Research Development Program of China (973 Program) (No. 2006CB503901), the National High Technology Research and Development program of China (863 program) (No. 2002AA223031) and the National Natural Science Foundation of China (No. 30972709, No. 81061120527). We are grateful to the population for participating in our study.
WOS记录号WOS:000297515600006
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13732
专题中国科学院心理健康重点实验室
通讯作者Shi, XH (reprint author), Beijing Hosp, Key Lab Geriatr, Inst Geriatr, Minist Hlth, Beijing 100730, Peoples R China.
作者单位1.Beijing Hosp, Key Lab Geriatr, Inst Geriatr, Minist Hlth, Beijing 100730, Peoples R China
2.Chinese Acad Sci, Inst Genet & Dev Biol, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Shi, Xiaohong,Wang, Li,Jin, Feng,et al. The ENPP1 K121Q polymorphism is not associated with type 2 diabetes in northern Chinese[J]. ACTA DIABETOLOGICA,2011,48(4):303-310.
APA Shi, Xiaohong.,Wang, Li.,Jin, Feng.,Sun, Junfeng.,Sun, Liang.,...&Shi, XH .(2011).The ENPP1 K121Q polymorphism is not associated with type 2 diabetes in northern Chinese.ACTA DIABETOLOGICA,48(4),303-310.
MLA Shi, Xiaohong,et al."The ENPP1 K121Q polymorphism is not associated with type 2 diabetes in northern Chinese".ACTA DIABETOLOGICA 48.4(2011):303-310.
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