The ENPP1 K121Q polymorphism is not associated with type 2 diabetes in northern Chinese

	The ENPP1 K121Q polymorphism is not associated with type 2 diabetes in northern Chinese
	Shi, Xiaohong 1; Wang, Li2 ; Jin, Feng3 ; Sun, Junfeng 1; Sun, Liang 1; Tang, Lei 1; Yang, Ze 1; Shi, XH (reprint author), Beijing Hosp, Key Lab Geriatr, Inst Geriatr, Minist Hlth, Beijing 100730, Peoples R China.
心理所单位排序	3
摘要	The K121Q polymorphism of the ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) gene has been studied in relation to insulin resistance, type 2 diabetes, and obesity, and conflicting results were observed in various populations. The purpose of the present study was to investigate the prevalence of K121Q polymorphism of ENPP1 gene and to clarify whether this polymorphism is associated with type 2 diabetes susceptibility in northern Chinese population. We studied the association of the ENPP1 K121Q polymorphism with type 2 diabetes (T2D) in 639 unrelated patients and 885 control subjects with normal glucose tolerance of northern China. The patients were diagnosed in accordance with the guidelines of the American Diabetes Association (ADA). Genotypes were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The distribution of KK, KQ, and QQ genotypes among patients was 79.5, 19.2, and 1.3%, similar to that of the control group (79.2, 20.1, and 0.7%). After readjusting for the confounding effects of age, gender, and BMI, no significant effect of genotypes on T2D was found for any of the genetic models tested (recessive model, dominant model, or additive model). All clinical characteristics tested were similar among the different genotypes, and no significant associations were observed both in T2D patients and in controls. When subgroup analyses of T2D patients and non-diabetic controls were stratified according to BMI and waist circumference, the variant was still not associated with T2D. The results showed that the ENPP1 K121Q polymorphism is not associated with genetic susceptibility of type 2 diabetes in the northern Chinese population.
关键词	ENPP1 Type 2 diabetes Polymorphism Northern Chinese
学科领域	Medical Psychology
	2011-12-01
语种	英语
发表期刊	ACTA DIABETOLOGICA
ISSN	0940-5429
卷号	48 期号:4 页码:303-310
期刊论文类型	Article
URL	查看原文
收录类别	SCI
项目简介	This research was supported by the grants from the Major State Basic Research Development Program of China (973 Program) (No. 2006CB503901), the National High Technology Research and Development program of China (863 program) (No. 2002AA223031) and the National Natural Science Foundation of China (No. 30972709, No. 81061120527). We are grateful to the population for participating in our study.
WOS记录号	WOS:000297515600006
资助机构	Major State Basic Research Development Program of China (973 Program) [2006CB503901] ; National High Technology Research and Development program of China (863 program) [2002AA223031] ; National Natural Science Foundation of China [30972709, 81061120527]
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/13732
专题	中国科学院心理健康重点实验室
通讯作者	Shi, XH (reprint author), Beijing Hosp, Key Lab Geriatr, Inst Geriatr, Minist Hlth, Beijing 100730, Peoples R China.
作者单位	1.Beijing Hosp, Key Lab Geriatr, Inst Geriatr, Minist Hlth, Beijing 100730, Peoples R China 2.Chinese Acad Sci, Inst Genet & Dev Biol, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Shi, Xiaohong,Wang, Li,Jin, Feng,et al. The ENPP1 K121Q polymorphism is not associated with type 2 diabetes in northern Chinese[J]. ACTA DIABETOLOGICA,2011,48(4):303-310.
APA	Shi, Xiaohong.,Wang, Li.,Jin, Feng.,Sun, Junfeng.,Sun, Liang.,...&Shi, XH .(2011).The ENPP1 K121Q polymorphism is not associated with type 2 diabetes in northern Chinese.ACTA DIABETOLOGICA,48(4),303-310.
MLA	Shi, Xiaohong,et al."The ENPP1 K121Q polymorphism is not associated with type 2 diabetes in northern Chinese".ACTA DIABETOLOGICA 48.4(2011):303-310.

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