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gamma-glutamyl transpeptidase 1 specifically suppresses green-light avoidance via GABA(A) receptors in Drosophila
Liu, Jiangqu1,2; Gong, Zhefeng1; Liu, Li1,3
2014-08-01
Source PublicationJOURNAL OF NEUROCHEMISTRY
ISSN0022-3042
SubtypeArticle
Volume130Issue:3Pages:408-418
AbstractDrosophila larvae innately show light avoidance behavior. Compared with robust blue-light avoidance, larvae exhibit relatively weaker green-light responses. In our previous screening for genes involved in larval light avoidance, compared with control w(1118) larvae, larvae with gamma-glutamyl transpeptidase 1 (Ggt-1) knockdown or Ggt-1 mutation were found to exhibit higher percentage of green-light avoidance which was mediated by Rhodopsin6 (Rh6) photoreceptors. However, their responses to blue light did not change significantly. By adjusting the expression level of Ggt-1 in different tissues, we found that Ggt-1 in malpighian tubules was both necessary and sufficient for green-light avoidance. Our results showed that glutamate levels were lower in Ggt-1 null mutants compared with controls. Feeding Ggt-1 null mutants glutamate can normalize green-light avoidance, indicating that high glutamate concentrations suppressed larval green-light avoidance. However, rather than directly, glutamate affected green-light avoidance indirectly through GABA, the level of which was also lower in Ggt-1 mutants compared with controls. Mutants in glutamate decarboxylase 1, which encodes GABA synthase, and knockdown lines of the GABA(A) receptor, both exhibit elevated levels of green-light avoidance. Thus, our results elucidate the neurobiological mechanisms mediating green-light avoidance, which was inhibited in wild-type larvae.
KeywordGaba Gaba(a) Receptor Ggt-1 Glutamate Green-light Avoidance
Indexed BySCI
Language英语
WOS IDWOS:000339479200008
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13740
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Liu, Jiangqu,Gong, Zhefeng,Liu, Li. gamma-glutamyl transpeptidase 1 specifically suppresses green-light avoidance via GABA(A) receptors in Drosophila[J]. JOURNAL OF NEUROCHEMISTRY,2014,130(3):408-418.
APA Liu, Jiangqu,Gong, Zhefeng,&Liu, Li.(2014).gamma-glutamyl transpeptidase 1 specifically suppresses green-light avoidance via GABA(A) receptors in Drosophila.JOURNAL OF NEUROCHEMISTRY,130(3),408-418.
MLA Liu, Jiangqu,et al."gamma-glutamyl transpeptidase 1 specifically suppresses green-light avoidance via GABA(A) receptors in Drosophila".JOURNAL OF NEUROCHEMISTRY 130.3(2014):408-418.
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