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The mood stabilizer lamotrigine produces antidepressant behavioral effects in rats: role of brain-derived neurotrophic factor
Li, Nanxin1,2,3; He, Xiaolu3; Qi, Xiaoli4; Zhang, Yu5; He, Shuchang3
2010-12-01
Source PublicationJOURNAL OF PSYCHOPHARMACOLOGY
ISSN0269-8811
SubtypeArticle
Volume24Issue:12Pages:1772-1778
AbstractThe anticonvulsant drug lamotrigine has been shown to produce strong antidepressant effects in the treatment of patients with bipolar disorder. However, to date there are few preclinical reports on its behavioral actions in animal models of depression or its underlying molecular mechanisms. The current study investigated the effects of lamotrigine in the forced swimming test and the learned helplessness test. The results demonstrate that both 15 and 30 mg/kg acute treatment of lamotrigine significantly reduced immobility in the forced swimming test without affecting locomotor activity. Sub-chronic twice daily injections of 30 mg/kg lamotrigine robustly decreased escape failures in animals that had developed learned helplessness symptoms. In parallel, the sub-chronic lamotrigine treatment also up-regulated frontal and hippocampal brain-derived neurotrophic factor expression in both naive and stressed animals and restored the stress-induced down-regulation of brain-derived neurotrophic factor expression. This study provides further evidence for the use of lamotrigine as a novel antidepressant in the treatment of bipolar disorders.
Keywordantidepressant brain derived neurotrophic factor forced swimming test lamotrigine learned helplessness
Indexed BySCI
Language英语
WOS IDWOS:000285044500006
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13763
Collection中国科学院心理研究所回溯数据库(1956-2010)
Affiliation1.Yale Univ, Div Mol Psychiat, Sch Med, New Haven, CT 06508 USA
2.Yale Univ, Dept Psychol, New Haven, CT 06520 USA
3.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
4.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
5.Beijing Union Univ, Dept Biol, Coll Arts & Sci, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Li, Nanxin,He, Xiaolu,Qi, Xiaoli,et al. The mood stabilizer lamotrigine produces antidepressant behavioral effects in rats: role of brain-derived neurotrophic factor[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2010,24(12):1772-1778.
APA Li, Nanxin,He, Xiaolu,Qi, Xiaoli,Zhang, Yu,&He, Shuchang.(2010).The mood stabilizer lamotrigine produces antidepressant behavioral effects in rats: role of brain-derived neurotrophic factor.JOURNAL OF PSYCHOPHARMACOLOGY,24(12),1772-1778.
MLA Li, Nanxin,et al."The mood stabilizer lamotrigine produces antidepressant behavioral effects in rats: role of brain-derived neurotrophic factor".JOURNAL OF PSYCHOPHARMACOLOGY 24.12(2010):1772-1778.
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