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MagicViewer: integrated solution for next-generation sequencing data visualization and genetic variation detection and annotation
Hou, Huabin1; Zhao, Fangqing2; Zhou, LingLin1; Zhu, Erle3; Teng, Huajing4; Li, Xiaokun3; Bao, Qiyu1; Wu, Jinyu1; Sun, Zhongsheng1,4
2010-07-01
Source PublicationNUCLEIC ACIDS RESEARCH
ISSN0305-1048
SubtypeArticle
Volume38Pages:W732-W736
AbstractNew sequencing technologies, such as Roche 454, ABI SOLiD and Illumina, have been increasingly developed at an astounding pace with the advantages of high throughput, reduced time and cost. To satisfy the impending need for deciphering the large-scale data generated from next-generation sequencing, an integrated software MagicViewer is developed to easily visualize short read mapping, identify and annotate genetic variation based on the reference genome. MagicViewer provides a user-friendly environment in which large-scale short reads can be displayed in a zoomable interface under user-defined color scheme through an operating system-independent manner. Meanwhile, it also holds a versatile computational pipeline for genetic variation detection, filtration, annotation and visualization, providing details of search option, functional classification, subset selection, sequence association and primer design. In conclusion, MagicViewer is a sophisticated assembly visualization and genetic variation annotation tool for next-generation sequencing data, which can be widely used in a variety of sequencing-based researches, including genome re-sequencing and transcriptome studies. MagicViewer is freely available at http://bioinformatics.zj.cn/magicviewer/.
Indexed BySCI
Language英语
WOS IDWOS:000284148900118
Citation statistics
Cited Times:34[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13773
Collection中国科学院心理研究所回溯数据库(1956-2010)
Affiliation1.Wenzhou Med Coll, Inst Genom Med, Wenzhou 325035, Peoples R China
2.Penn State Univ, Dept Biochem & Mol Biol, Ctr Comparat Genom & Bioinformat, University Pk, PA 16802 USA
3.Wenzhou Med Coll, Sch Pharmaceut Sci, Zhejiang Prov Key Lab Biotechnol Pharmaceut Engn, Wenzhou 325035, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Behav Genet Ctr, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Hou, Huabin,Zhao, Fangqing,Zhou, LingLin,et al. MagicViewer: integrated solution for next-generation sequencing data visualization and genetic variation detection and annotation[J]. NUCLEIC ACIDS RESEARCH,2010,38:W732-W736.
APA Hou, Huabin.,Zhao, Fangqing.,Zhou, LingLin.,Zhu, Erle.,Teng, Huajing.,...&Sun, Zhongsheng.(2010).MagicViewer: integrated solution for next-generation sequencing data visualization and genetic variation detection and annotation.NUCLEIC ACIDS RESEARCH,38,W732-W736.
MLA Hou, Huabin,et al."MagicViewer: integrated solution for next-generation sequencing data visualization and genetic variation detection and annotation".NUCLEIC ACIDS RESEARCH 38(2010):W732-W736.
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