MagicViewer: integrated solution for next-generation sequencing data visualization and genetic variation detection and annotation
Hou, Huabin1; Zhao, Fangqing2; Zhou, LingLin1; Zhu, Erle3; Teng, Huajing4; Li, Xiaokun3; Bao, Qiyu1; Wu, Jinyu1; Sun, Zhongsheng1,4
2010-07-01
发表期刊NUCLEIC ACIDS RESEARCH
ISSN0305-1048
文章类型Article
卷号38页码:W732-W736
摘要New sequencing technologies, such as Roche 454, ABI SOLiD and Illumina, have been increasingly developed at an astounding pace with the advantages of high throughput, reduced time and cost. To satisfy the impending need for deciphering the large-scale data generated from next-generation sequencing, an integrated software MagicViewer is developed to easily visualize short read mapping, identify and annotate genetic variation based on the reference genome. MagicViewer provides a user-friendly environment in which large-scale short reads can be displayed in a zoomable interface under user-defined color scheme through an operating system-independent manner. Meanwhile, it also holds a versatile computational pipeline for genetic variation detection, filtration, annotation and visualization, providing details of search option, functional classification, subset selection, sequence association and primer design. In conclusion, MagicViewer is a sophisticated assembly visualization and genetic variation annotation tool for next-generation sequencing data, which can be widely used in a variety of sequencing-based researches, including genome re-sequencing and transcriptome studies. MagicViewer is freely available at http://bioinformatics.zj.cn/magicviewer/.
收录类别SCI
语种英语
WOS记录号WOS:000284148900118
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13773
专题中国科学院心理研究所回溯数据库(1956-2010)
作者单位1.Wenzhou Med Coll, Inst Genom Med, Wenzhou 325035, Peoples R China
2.Penn State Univ, Dept Biochem & Mol Biol, Ctr Comparat Genom & Bioinformat, University Pk, PA 16802 USA
3.Wenzhou Med Coll, Sch Pharmaceut Sci, Zhejiang Prov Key Lab Biotechnol Pharmaceut Engn, Wenzhou 325035, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Behav Genet Ctr, Beijing 100101, Peoples R China
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GB/T 7714
Hou, Huabin,Zhao, Fangqing,Zhou, LingLin,et al. MagicViewer: integrated solution for next-generation sequencing data visualization and genetic variation detection and annotation[J]. NUCLEIC ACIDS RESEARCH,2010,38:W732-W736.
APA Hou, Huabin.,Zhao, Fangqing.,Zhou, LingLin.,Zhu, Erle.,Teng, Huajing.,...&Sun, Zhongsheng.(2010).MagicViewer: integrated solution for next-generation sequencing data visualization and genetic variation detection and annotation.NUCLEIC ACIDS RESEARCH,38,W732-W736.
MLA Hou, Huabin,et al."MagicViewer: integrated solution for next-generation sequencing data visualization and genetic variation detection and annotation".NUCLEIC ACIDS RESEARCH 38(2010):W732-W736.
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