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Proteomic and transcriptomic analysis of visual long-term memory in Drosophila melanogaster
Jiang, Huoqing1,2; Hou, Qinlong1,2; Gong, Zhefeng1; Liu, Li1,3
2011-03-01
发表期刊PROTEIN & CELL
ISSN1674-800X
文章类型Article
卷号2期号:3页码:215-222
摘要The fruit fly, Drosophila melanogaster, is able to discriminate visual landmarks and form visual long-term memory in a flight simulator. Studies focused on the molecular mechanism of long-term memory have shown that memory formation requires mRNA transcription and protein synthesis. However, little is known about the molecular mechanisms underlying the visual learning paradigm. The present study demonstrated that both spaced training procedure (STP) and consecutive training procedure (CTP) would induce long-term memory at 12 hour after training, and STP caused significantly higher 12-h memory scores compared with CTP. Label-free quantification of liquid chromatography-tandem mass spectrometry (LC-MS/MS) and microarray were utilized to analyze proteomic and transcriptomic differences between the STP and CTP groups. Proteomic analysis revealed 30 up-regulated and 27 down-regulated proteins; Transcriptomic analysis revealed 145 up-regulated and 129 down- regulated genes. Among them, five candidate genes were verified by quantitative PCR, which revealed results similar to microarray. These results provide insight into the molecular components influencing visual long-termmemory and facilitate further studies on the roles of identified genes in memory formation.
关键词Visual Learning And Memory Drosophila Long-term Memory Microarray Liquid Chromatography-tandem Mass Spectrometry
收录类别SCI
语种英语
WOS记录号WOS:000310519700006
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13791
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Jiang, Huoqing,Hou, Qinlong,Gong, Zhefeng,et al. Proteomic and transcriptomic analysis of visual long-term memory in Drosophila melanogaster[J]. PROTEIN & CELL,2011,2(3):215-222.
APA Jiang, Huoqing,Hou, Qinlong,Gong, Zhefeng,&Liu, Li.(2011).Proteomic and transcriptomic analysis of visual long-term memory in Drosophila melanogaster.PROTEIN & CELL,2(3),215-222.
MLA Jiang, Huoqing,et al."Proteomic and transcriptomic analysis of visual long-term memory in Drosophila melanogaster".PROTEIN & CELL 2.3(2011):215-222.
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