Institutional Repository, Institute of Psychology, Chinese Academy of Sciences
Huperzine A reverses scopolamine- and muscimol-induced memory deficits in chick | |
Gao, Y; Tang, XC; Guan, LC; Kuang, PZ | |
摘要 | AIM: To study the effects of huperzine A on disruption of spatial memory induced by scopolamine (a muscarinic antagonist) and muscimol (a GABA(A) agonist) in passive avoidance task. METHODS: One-trial passive avoidance task was used to investigate the effects of huperzine A. The avoidance rate was used to evaluate memory retention. RESULTS: Both scopolamine (100 ng)and muscimol (50 ng), injected intracranially 5 min before training, resulted in a decreased avoidance rate. Huperzine A (25 ng), injected intracranially 15 min before training, reversed memory deficits induced by scopolamine and muscimol at 30 min after training, and this reversal persisted at least 1 h. The improving effects of huperzine A exhibited a bell-shaped dose-response curve. CONCLUSION: Huperzine A improved the process of memory formation not only by acting as a highly potent and selective inhibitor of AChE, but also by antagonizing effects mediated through the GABA(A) receptor. |
关键词 | Cholinesterases Huperzine a Scopolamine Muscimol Gaba Avoidance Learning Memory Chickens |
2000-12-01 | |
语种 | 英语 |
发表期刊 | ACTA PHARMACOLOGICA SINICA |
ISSN | 0253-9756 |
卷号 | 21期号:12页码:1169-1173 |
期刊论文类型 | Article |
收录类别 | SCI |
WOS记录号 | WOS:000165828500019 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/13805 |
专题 | 中国科学院心理研究所回溯数据库(1956-2010) |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China |
推荐引用方式 GB/T 7714 | Gao, Y,Tang, XC,Guan, LC,et al. Huperzine A reverses scopolamine- and muscimol-induced memory deficits in chick[J]. ACTA PHARMACOLOGICA SINICA,2000,21(12):1169-1173. |
APA | Gao, Y,Tang, XC,Guan, LC,&Kuang, PZ.(2000).Huperzine A reverses scopolamine- and muscimol-induced memory deficits in chick.ACTA PHARMACOLOGICA SINICA,21(12),1169-1173. |
MLA | Gao, Y,et al."Huperzine A reverses scopolamine- and muscimol-induced memory deficits in chick".ACTA PHARMACOLOGICA SINICA 21.12(2000):1169-1173. |
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