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Huperzine A reverses scopolamine- and muscimol-induced memory deficits in chick
Gao, Y; Tang, XC; Guan, LC; Kuang, PZ
2000-12-01
Source PublicationACTA PHARMACOLOGICA SINICA
ISSN0253-9756
SubtypeArticle
Volume21Issue:12Pages:1169-1173
AbstractAIM: To study the effects of huperzine A on disruption of spatial memory induced by scopolamine (a muscarinic antagonist) and muscimol (a GABA(A) agonist) in passive avoidance task. METHODS: One-trial passive avoidance task was used to investigate the effects of huperzine A. The avoidance rate was used to evaluate memory retention. RESULTS: Both scopolamine (100 ng)and muscimol (50 ng), injected intracranially 5 min before training, resulted in a decreased avoidance rate. Huperzine A (25 ng), injected intracranially 15 min before training, reversed memory deficits induced by scopolamine and muscimol at 30 min after training, and this reversal persisted at least 1 h. The improving effects of huperzine A exhibited a bell-shaped dose-response curve. CONCLUSION: Huperzine A improved the process of memory formation not only by acting as a highly potent and selective inhibitor of AChE, but also by antagonizing effects mediated through the GABA(A) receptor.
KeywordCholinesterases Huperzine a Scopolamine Muscimol Gaba Avoidance Learning Memory Chickens
Indexed BySCI
Language英语
WOS IDWOS:000165828500019
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13805
Collection中国科学院心理研究所回溯数据库(1956-2010)
Affiliation1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Gao, Y,Tang, XC,Guan, LC,et al. Huperzine A reverses scopolamine- and muscimol-induced memory deficits in chick[J]. ACTA PHARMACOLOGICA SINICA,2000,21(12):1169-1173.
APA Gao, Y,Tang, XC,Guan, LC,&Kuang, PZ.(2000).Huperzine A reverses scopolamine- and muscimol-induced memory deficits in chick.ACTA PHARMACOLOGICA SINICA,21(12),1169-1173.
MLA Gao, Y,et al."Huperzine A reverses scopolamine- and muscimol-induced memory deficits in chick".ACTA PHARMACOLOGICA SINICA 21.12(2000):1169-1173.
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