Association analysis of NAD(P)H : quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease
Wang, Binbin; Jin, Feng; Xie, Yanchen; Tang, Ying; Kan, Rui; Zheng, Chenguang; Yang, Ze; Wang, Li
2006-12-06
发表期刊NEUROSCIENCE LETTERS
ISSN0304-3940
文章类型Article
卷号409期号:3页码:179-181
摘要Alterations of the NAD(P)H:quinone oxidoreductase (NQO1) activity are associated with Alzheimer's disease (AD). A polymorphism consisting of a single nucleotide (C -> T) change at position 609 of NQO1 influences the NQO1 activity. Therefore the NQO1 C609T polymorphism may confer susceptibility for AD developing. To test the hypothesis, we have performed an association study between the NQO1 gene polymorphism C609T and late-onset Alzheimer's disease (LOAD) in Chinese population. Totally 104 LOAD patients and 128 controls were enrolled in our data set. All subjects were genotyped for NQO1 and Apolipoprotein E (APOE). There were no significant differences in NQO1 genotype or allele frequencies between cases and controls. Likewise, with the stratification of APOE epsilon 4 status, no statistical difference was observed between cases and controls. Our findings suggested that this polymorphism might not represent additional genetic risk factor for LOAD. However, the present study cannot exclude NQO1 as a possible candidate for LOAD. Further study in a larger population and biological functional analysis of NQO1 gene is required to verify the role of NQO1 in LOAD. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
关键词late-onset Alzheimer's disease APOE epsilon 4 NQO1 case-control study Chinese
收录类别SCI
语种英语
WOS记录号WOS:000242448500004
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/14076
专题中国科学院心理研究所回溯数据库(1956-2010)
作者单位1.Chinese Acad Sci, Ctr Human & Anim Genet, Inst Genet & Dev Biol, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Res Lab Behav Biol, Beijing 100101, Peoples R China
3.Affiliate Capital Univ Med Sci, Beijing Friendship Hosp, Dept Neurol, Beijing 100050, Peoples R China
4.Beijing Hosp, Minist Hlth, Inst Geriatr, Med Genet Lab, Beijing 100730, Peoples R China
5.Jiangbin Hosp, Nanning 530021, Guangxi, Peoples R China
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Wang, Binbin,Jin, Feng,Xie, Yanchen,et al. Association analysis of NAD(P)H : quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease[J]. NEUROSCIENCE LETTERS,2006,409(3):179-181.
APA Wang, Binbin.,Jin, Feng.,Xie, Yanchen.,Tang, Ying.,Kan, Rui.,...&Wang, Li.(2006).Association analysis of NAD(P)H : quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease.NEUROSCIENCE LETTERS,409(3),179-181.
MLA Wang, Binbin,et al."Association analysis of NAD(P)H : quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease".NEUROSCIENCE LETTERS 409.3(2006):179-181.
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