Association analysis of NAD(P)H : quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease

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	Association analysis of NAD(P)H : quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease
	Wang, Binbin ; Jin, Feng; Xie, Yanchen ; Tang, Ying ; Kan, Rui ; Zheng, Chenguang ; Yang, Ze ; Wang, Li
摘要	Alterations of the NAD(P)H:quinone oxidoreductase (NQO1) activity are associated with Alzheimer's disease (AD). A polymorphism consisting of a single nucleotide (C -> T) change at position 609 of NQO1 influences the NQO1 activity. Therefore the NQO1 C609T polymorphism may confer susceptibility for AD developing. To test the hypothesis, we have performed an association study between the NQO1 gene polymorphism C609T and late-onset Alzheimer's disease (LOAD) in Chinese population. Totally 104 LOAD patients and 128 controls were enrolled in our data set. All subjects were genotyped for NQO1 and Apolipoprotein E (APOE). There were no significant differences in NQO1 genotype or allele frequencies between cases and controls. Likewise, with the stratification of APOE epsilon 4 status, no statistical difference was observed between cases and controls. Our findings suggested that this polymorphism might not represent additional genetic risk factor for LOAD. However, the present study cannot exclude NQO1 as a possible candidate for LOAD. Further study in a larger population and biological functional analysis of NQO1 gene is required to verify the role of NQO1 in LOAD. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
关键词	late-onset Alzheimer's disease APOE epsilon 4 NQO1 case-control study Chinese
	2006-12-06
语种	英语
发表期刊	NEUROSCIENCE LETTERS
ISSN	0304-3940
卷号	409 期号:3 页码:179-181
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000242448500004
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/14076
专题	中国科学院心理研究所回溯数据库(1956-2010)
作者单位	1.Chinese Acad Sci, Ctr Human & Anim Genet, Inst Genet & Dev Biol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Res Lab Behav Biol, Beijing 100101, Peoples R China 3.Affiliate Capital Univ Med Sci, Beijing Friendship Hosp, Dept Neurol, Beijing 100050, Peoples R China 4.Beijing Hosp, Minist Hlth, Inst Geriatr, Med Genet Lab, Beijing 100730, Peoples R China 5.Jiangbin Hosp, Nanning 530021, Guangxi, Peoples R China
推荐引用方式 GB/T 7714	Wang, Binbin,Jin, Feng,Xie, Yanchen,et al. Association analysis of NAD(P)H : quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease[J]. NEUROSCIENCE LETTERS,2006,409(3):179-181.
APA	Wang, Binbin.,Jin, Feng.,Xie, Yanchen.,Tang, Ying.,Kan, Rui.,...&Wang, Li.(2006).Association analysis of NAD(P)H : quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease.NEUROSCIENCE LETTERS,409(3),179-181.
MLA	Wang, Binbin,et al."Association analysis of NAD(P)H : quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease".NEUROSCIENCE LETTERS 409.3(2006):179-181.