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Comparative RNA-seq analysis reveals potential mechanisms mediating the conversion to androgen independence in an LNCaP progression cell model
Wang, Yongqing1,2,3; Wang, Yan1,2,3; Liu, Qi4; Xu, Gang5; Mao, Fengbiao2,6; Qin, Tingting5; Teng, Huajing6; Cai, Wanshi2,4,6; Yu, Ping4; Cai, Tao4; Zhao, Mei1,3; Sun, Zhong Sheng1,4,6; Xie, Congying7
2014
Source PublicationCANCER LETTERS
ISSN0304-3835
SubtypeArticle
Volume342Issue:1Pages:130-138
AbstractThe androgen-independent phenotype is an important symptom of refractory prostate cancer. However, the molecular mechanisms underlying this phenotypic conversion remain unclear. Using RNA-seq analysis of androgen-dependent prostate cancer cells (LNCaP) vs. androgen-independent cancer cells (LNCaP-AI-F), we identified 788 differentially expressed genes, 315 alternative splicing events, and eight novel LNCaP-AI-F-specific fusion genes. The fusion genes ElF2AK1-ATR and GLYR1-SLC9A8 were predicted to be damaging and oncogenic. We also observed dramatic changes in androgen receptor (AR)-mediated pathway molecules, including prostate-specific antigen (PSA, a major biomarker of prostate cancer) and AR variants, as well as neuroendocrine-like (NE-like) and tumor stem cell-like characteristics, during androgen-independent phenotype progression. Our findings provide new insights into the regulatory complexities of refractory prostate cancers. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
KeywordProstate cancer Androgen-independent RNA-seq Alternative splicing Fusion gene Tumor stem cell-like
Indexed BySCI
Language英语
WOS IDWOS:000328591100015
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Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14105
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Behav Genet Ctr, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.Wenzhou Med Coll, Inst Genom Med, Wenzhou, Zhejiang, Peoples R China
5.Wenzhou Med Coll, Affiliated Hosp 1, Ctr Clin Lab Diag, Wenzhou, Zhejiang, Peoples R China
6.Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China
7.Wenzhou Med Coll, Affiliated Hosp 1, Radiotherapy & Chemotherapy Dept, Wenzhou, Zhejiang, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Wang, Yongqing,Wang, Yan,Liu, Qi,et al. Comparative RNA-seq analysis reveals potential mechanisms mediating the conversion to androgen independence in an LNCaP progression cell model[J]. CANCER LETTERS,2014,342(1):130-138.
APA Wang, Yongqing.,Wang, Yan.,Liu, Qi.,Xu, Gang.,Mao, Fengbiao.,...&Xie, Congying.(2014).Comparative RNA-seq analysis reveals potential mechanisms mediating the conversion to androgen independence in an LNCaP progression cell model.CANCER LETTERS,342(1),130-138.
MLA Wang, Yongqing,et al."Comparative RNA-seq analysis reveals potential mechanisms mediating the conversion to androgen independence in an LNCaP progression cell model".CANCER LETTERS 342.1(2014):130-138.
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