Institutional Repository of Key Laboratory of Mental Health, CAS
| Disrupted cortical network as a vulnerability marker for obsessive-compulsive disorder | |
Peng, Ziwen1,2; Shi, Feng1; Shi, Changzheng3; Yang, Qiong4; Chan, Raymond C. K.5 ; Shen, Dinggang1,6
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| Abstract | Morphological alterations of brain structure are generally assumed to be involved in the pathophysiology of obsessive-compulsive disorder (OCD). Yet, little is known about the morphological connectivity properties of structural brain networks in OCD or about the heritability of those morphological connectivity properties. To better understand these properties, we conducted a study that defined three different groups: OCD group with 30 subjects, siblings group with 19 subjects, and matched controls group with 30 subjects. A structural brain network was constructed using 68 cortical regions of each subject within their respective group (i.e., one brain network for each group). Both small-worldness and modularity were measured to reflect the morphological connectivity properties of each constructed structural brain network. When compared to the matched controls, the structural brain networks of patients with OCD indeed exhibited atypical small-worldness and modularity. Specifically, small-worldness showed decreased local efficiency, and modularity showed reduced intra-connectivity in Module III (default mode network) and increased interconnectivity between Module I (executive function) and Module II (cognitive control/spatial). Intriguingly, the structured brain networks of the unaffected siblings showed similar small-worldness and modularity as OCD patients. Based on the atypical structural brain networks observed in OCD patients and their unaffected siblings, abnormal small-worldness and modularity may indicate a candidate endophenotype for OCD. |
| Keyword | Obsessive-compulsive Disorder Cortical Thickness Brain Networks Modularity Small-worldness |
| 2014-09-01 | |
| Language | 英语 |
| Source Publication | BRAIN STRUCTURE & FUNCTION
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| ISSN | 1863-2653 |
| Volume | 219Issue:5Pages:1801-1812 |
| Subtype | Article |
| Indexed By | SCI |
| WOS ID | WOS:000341375500021 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.psych.ac.cn/handle/311026/14107 |
| Collection | 中国科学院心理健康重点实验室 |
| Affiliation | 1.Univ N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA 2.S China Normal Univ, Dept Psychol, Guangzhou, Guangdong, Peoples R China 3.Jinan Univ, Affiliated Hosp 1, Med Imaging Ctr, Guangzhou, Guangdong, Peoples R China 4.Guangzhou Psychiat Hosp, Guangzhou, Guangdong, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 6.Korea Univ, Dept Brain & Cognit Engn, Seoul, South Korea |
| Recommended Citation GB/T 7714 | Peng, Ziwen,Shi, Feng,Shi, Changzheng,et al. Disrupted cortical network as a vulnerability marker for obsessive-compulsive disorder[J]. BRAIN STRUCTURE & FUNCTION,2014,219(5):1801-1812. |
| APA | Peng, Ziwen,Shi, Feng,Shi, Changzheng,Yang, Qiong,Chan, Raymond C. K.,&Shen, Dinggang.(2014).Disrupted cortical network as a vulnerability marker for obsessive-compulsive disorder.BRAIN STRUCTURE & FUNCTION,219(5),1801-1812. |
| MLA | Peng, Ziwen,et al."Disrupted cortical network as a vulnerability marker for obsessive-compulsive disorder".BRAIN STRUCTURE & FUNCTION 219.5(2014):1801-1812. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| WOS_000341375500021.（1178KB） | 期刊论文 | 出版稿 | 暂不开放 | CC BY-NC-SA | Application Full Text | |
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