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Disrutpted resting-state functional architecture of the brain after 45-day simulated microgravity
Zhou, Yuan1,2; Wang, Yun1,2,3; Rao, Li-Lin1,2; Liang, Zhu-Yuan1,2; Chen, Xiao-Ping4; Zheng, Dang1,2,3; Tan, Cheng4; Tian, Zhi-Qiang4; Wang, Chun-Hui4; Bai, Yan-Qiang4; Chen, Shan-Guang4; Li, Shu1,2
2014-06-05
Source PublicationFRONTIERS IN BEHAVIORAL NEUROSCIENCE
ISSN1662-5153
SubtypeArticle
Volume8Issue:0Pages:200
AbstractLong-term spaceflight induces both physiological and psychological changes in astronauts. To understand the neural mechanisms underlying these physiological and psychological changes, it is critical to investigate the effects of microgravity on the functional architecture of the brain. In this study, we used resting-state functional M RI (rs-fMR I) to study whether the functional architecture of the brain is altered after 45 days of -6 degrees head-down tilt (HDT) bed rest, which is a reliable model for the simulation of microgravity. Sixteen healthy male volunteers underwent rs-fMRI scans before and after 45 days of -6 degrees HDT bed rest. Specifically, we used a commonly employed graph-based measure of network organization, i.e., degree centrality (DC), to perform a full-brain exploration of the regions that were influenced by simulated microgravity. We subsequently examined the functional connectivities of these regions using a seed-based resting-state functional connectivity (RSFC) analysis. We found decreased DC in two regions, the left anterior insula (aINS) and the anterior part of the middle cingulate cortex (MCC; also called the dorsal anterior cingulate cortex in many studies), in the male volunteers after 45 days of -6 degrees HDT bed rest. Furthermore, seed-based RSFC analyses revealed that a functional network anchored in the aINS and MCC was particularly influenced by simulated microgravity. These results provide evidence that simulated microgravity alters the resting-state functional architecture of the brains of males and suggest that the processing of salience information, which is primarily subserved by the aINS MCC functional network, is particularly influenced by spaceflight. The current findings provide a new perspective for understanding the relationships between microgravity, cognitive function, autonomic neural function, and central neural activity.
KeywordAnterior Insula Cingulate Cortex Head-down Tilt Bed Rest Functional Magnetic Resonance Imaging (Fmri) Functional Connectivity Resting State
Indexed BySCI
Language英语
WOS IDWOS:000336795900001
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14120
Collection中国科学院行为科学重点实验室
Affiliation1.Chinese Acad Sci, Key Lab Behav Sci, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.China Astronaut Res & Training Ctr, Natl Key Lab Human Factors Engn, Beijing 100094, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Yuan,Wang, Yun,Rao, Li-Lin,et al. Disrutpted resting-state functional architecture of the brain after 45-day simulated microgravity[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2014,8(0):200.
APA Zhou, Yuan.,Wang, Yun.,Rao, Li-Lin.,Liang, Zhu-Yuan.,Chen, Xiao-Ping.,...&Li, Shu.(2014).Disrutpted resting-state functional architecture of the brain after 45-day simulated microgravity.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,8(0),200.
MLA Zhou, Yuan,et al."Disrutpted resting-state functional architecture of the brain after 45-day simulated microgravity".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 8.0(2014):200.
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