Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks

	Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks
	Chen, Xiaoyu 1; Wang, Huiying1 ; Lin, Zhang 2; Li, Sa 1; Li, Yonghui3 ; Bergen, Hugo T.2; Vrontakis, Maria E.2; Kirouac, Gilbert J.1,4
摘要	Orexins (hypocretins) are peptides that have been shown to regulate behavioral arousal and wakefulness. Recent evidence indicates that orexin neurons are activated by stress and that orexins play a role in anxiety. The present paper describes a series of experiments that examined whether orexins are involved in the anxiety that resulted from exposing rats to an acute episode of footshocks (5 x 2 s of 1.5 mA shocks). We found that prepro-orexin (ppOX) mRNA was elevated in rats at 6 and 14 days after exposure to footshock and that ppOX mRNA levels were correlated with fear at 14 days post-shock. Systemic injections of the non-selective dual orexin receptor antagonist TCS-1102 (10 and 20 mg/kg, i.p.) were found to decrease fear and anxiety in rats 14 days after exposure to footshock. We also found that rats that exhibited a high level of immobility to a novel tone the day after the footshock episode (high responders, HR) showed significantly elevated levels of ppOX mRNA at 14 days post-shock compared to control rats. Furthermore, TCS-1102 (10 mg/kg, i.p.) was found to have anxiolytic effects that were specific for HR when tested in the elevated T-maze. This study provides evidence linking the orexin system to the anxiety produced by exposure of rats to a single episode of footshocks. It also provides preclinical evidence in support of the use of orexin antagonists for the treatment of anxiety in response to an acute episode of stress.
关键词	Orexin Hypocretin Fear Anxiety Post-traumatic Stress Disorder Arousal
	2014-11-01
语种	英语
发表期刊	BRAIN STRUCTURE & FUNCTION
ISSN	1863-2653
卷号	219 期号:6 页码:2103-2118
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000344879200018
引用统计	被引频次：45[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/14122
专题	中国科学院心理健康重点实验室
作者单位	1.Univ Manitoba, Dept Oral Biol, Fac Dent, Winnipeg, MB R3E 0W2, Canada 2.Univ Manitoba, Fac Med, Dept Human Anat & Cell Sci, Winnipeg, MB R3E 0W2, Canada 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 4.Univ Manitoba, Fac Med, Dept Psychiat, Winnipeg, MB, Canada
推荐引用方式 GB/T 7714	Chen, Xiaoyu,Wang, Huiying,Lin, Zhang,et al. Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks[J]. BRAIN STRUCTURE & FUNCTION,2014,219(6):2103-2118.
APA	Chen, Xiaoyu.,Wang, Huiying.,Lin, Zhang.,Li, Sa.,Li, Yonghui.,...&Kirouac, Gilbert J..(2014).Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks.BRAIN STRUCTURE & FUNCTION,219(6),2103-2118.
MLA	Chen, Xiaoyu,et al."Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks".BRAIN STRUCTURE & FUNCTION 219.6(2014):2103-2118.

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