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Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks
Chen, Xiaoyu1; Wang, Huiying1; Lin, Zhang2; Li, Sa1; Li, Yonghui3; Bergen, Hugo T.2; Vrontakis, Maria E.2; Kirouac, Gilbert J.1,4
2014-11-01
Source PublicationBRAIN STRUCTURE & FUNCTION
ISSN1863-2653
SubtypeArticle
Volume219Issue:6Pages:2103-2118
AbstractOrexins (hypocretins) are peptides that have been shown to regulate behavioral arousal and wakefulness. Recent evidence indicates that orexin neurons are activated by stress and that orexins play a role in anxiety. The present paper describes a series of experiments that examined whether orexins are involved in the anxiety that resulted from exposing rats to an acute episode of footshocks (5 x 2 s of 1.5 mA shocks). We found that prepro-orexin (ppOX) mRNA was elevated in rats at 6 and 14 days after exposure to footshock and that ppOX mRNA levels were correlated with fear at 14 days post-shock. Systemic injections of the non-selective dual orexin receptor antagonist TCS-1102 (10 and 20 mg/kg, i.p.) were found to decrease fear and anxiety in rats 14 days after exposure to footshock. We also found that rats that exhibited a high level of immobility to a novel tone the day after the footshock episode (high responders, HR) showed significantly elevated levels of ppOX mRNA at 14 days post-shock compared to control rats. Furthermore, TCS-1102 (10 mg/kg, i.p.) was found to have anxiolytic effects that were specific for HR when tested in the elevated T-maze. This study provides evidence linking the orexin system to the anxiety produced by exposure of rats to a single episode of footshocks. It also provides preclinical evidence in support of the use of orexin antagonists for the treatment of anxiety in response to an acute episode of stress.
KeywordOrexin Hypocretin Fear Anxiety Post-traumatic Stress Disorder Arousal
Indexed BySCI
Language英语
WOS IDWOS:000344879200018
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14122
Collection中国科学院心理健康重点实验室
Affiliation1.Univ Manitoba, Dept Oral Biol, Fac Dent, Winnipeg, MB R3E 0W2, Canada
2.Univ Manitoba, Fac Med, Dept Human Anat & Cell Sci, Winnipeg, MB R3E 0W2, Canada
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.Univ Manitoba, Fac Med, Dept Psychiat, Winnipeg, MB, Canada
Recommended Citation
GB/T 7714
Chen, Xiaoyu,Wang, Huiying,Lin, Zhang,et al. Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks[J]. BRAIN STRUCTURE & FUNCTION,2014,219(6):2103-2118.
APA Chen, Xiaoyu.,Wang, Huiying.,Lin, Zhang.,Li, Sa.,Li, Yonghui.,...&Kirouac, Gilbert J..(2014).Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks.BRAIN STRUCTURE & FUNCTION,219(6),2103-2118.
MLA Chen, Xiaoyu,et al."Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks".BRAIN STRUCTURE & FUNCTION 219.6(2014):2103-2118.
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