Institutional Repository of Key Laboratory of Mental Health, CAS
| Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks | |
Chen, Xiaoyu1; Wang, Huiying1 ; Lin, Zhang2; Li, Sa1; Li, Yonghui3; Bergen, Hugo T.2; Vrontakis, Maria E.2; Kirouac, Gilbert J.1,4
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| 2014-11-01 | |
| Source Publication | BRAIN STRUCTURE & FUNCTION
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| ISSN | 1863-2653 |
| Subtype | Article |
| Volume | 219Issue:6Pages:2103-2118 |
| Abstract | Orexins (hypocretins) are peptides that have been shown to regulate behavioral arousal and wakefulness. Recent evidence indicates that orexin neurons are activated by stress and that orexins play a role in anxiety. The present paper describes a series of experiments that examined whether orexins are involved in the anxiety that resulted from exposing rats to an acute episode of footshocks (5 x 2 s of 1.5 mA shocks). We found that prepro-orexin (ppOX) mRNA was elevated in rats at 6 and 14 days after exposure to footshock and that ppOX mRNA levels were correlated with fear at 14 days post-shock. Systemic injections of the non-selective dual orexin receptor antagonist TCS-1102 (10 and 20 mg/kg, i.p.) were found to decrease fear and anxiety in rats 14 days after exposure to footshock. We also found that rats that exhibited a high level of immobility to a novel tone the day after the footshock episode (high responders, HR) showed significantly elevated levels of ppOX mRNA at 14 days post-shock compared to control rats. Furthermore, TCS-1102 (10 mg/kg, i.p.) was found to have anxiolytic effects that were specific for HR when tested in the elevated T-maze. This study provides evidence linking the orexin system to the anxiety produced by exposure of rats to a single episode of footshocks. It also provides preclinical evidence in support of the use of orexin antagonists for the treatment of anxiety in response to an acute episode of stress. |
| Keyword | Orexin Hypocretin Fear Anxiety Post-traumatic Stress Disorder Arousal |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000344879200018 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.psych.ac.cn/handle/311026/14122 |
| Collection | 中国科学院心理健康重点实验室 |
| Affiliation | 1.Univ Manitoba, Dept Oral Biol, Fac Dent, Winnipeg, MB R3E 0W2, Canada 2.Univ Manitoba, Fac Med, Dept Human Anat & Cell Sci, Winnipeg, MB R3E 0W2, Canada 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 4.Univ Manitoba, Fac Med, Dept Psychiat, Winnipeg, MB, Canada |
| Recommended Citation GB/T 7714 | Chen, Xiaoyu,Wang, Huiying,Lin, Zhang,et al. Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks[J]. BRAIN STRUCTURE & FUNCTION,2014,219(6):2103-2118. |
| APA | Chen, Xiaoyu.,Wang, Huiying.,Lin, Zhang.,Li, Sa.,Li, Yonghui.,...&Kirouac, Gilbert J..(2014).Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks.BRAIN STRUCTURE & FUNCTION,219(6),2103-2118. |
| MLA | Chen, Xiaoyu,et al."Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks".BRAIN STRUCTURE & FUNCTION 219.6(2014):2103-2118. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| WOS_000344879200018.（2906KB） | 期刊论文 | 出版稿 | 暂不开放 | CC BY-NC-SA | Application Full Text | |
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