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Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment
Shao, Shuang1; Li, Man1; Du, Wei1; Shao, Feng1; Wang, Weiwen2
2014-11-17
发表期刊BRAIN RESEARCH
ISSN0006-8993
文章类型Article
卷号1589期号:1589页码:105-111
摘要Adolescence is a critical period for neurodevelopment. MK-801 treatment and social isolation are important animal models for various neurodevelopmental disorders. Dysfunctions in the central cholinergic system are involved in creating the cognitive deficits observed in neurological diseases. In the present study, we aimed to investigate whether the acetylcholinesterase inhibitor galanthamine could reverse pre-cognitive prepulse inhibition (PPI) deficits and spatial learning deficits of adult rats in the Morris water maze. We induced these effects using either adolescent MK-801 treatment or social isolation from postnatal day (PND) 38-51. Our results showed that both adolescent social isolation and MK-801 treatment impaired PPI in adult rats, but neither had an effect on spatial learning. Furthermore, galanthamine injections over 7 days significantly enhanced PPI of normal rats and improved PPI disruption induced by adolescent pharmacological and rearing interventions. The results suggest that acetylcholinesterase inhibitors, such as galanthamine, might have the potential to improve pre-cognition in neurodevelopmental diseases by improving auditory sensory gating. (C) 2014 Elsevier B.V. All rights reserved.
关键词Adolescence Mk-801 Social Isolation Galanthamine Prepulse Inhibition
收录类别SCI
语种英语
WOS记录号WOS:000345732600011
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/14128
专题中国科学院心理健康重点实验室
作者单位1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Shao, Shuang,Li, Man,Du, Wei,et al. Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment[J]. BRAIN RESEARCH,2014,1589(1589):105-111.
APA Shao, Shuang,Li, Man,Du, Wei,Shao, Feng,&Wang, Weiwen.(2014).Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment.BRAIN RESEARCH,1589(1589),105-111.
MLA Shao, Shuang,et al."Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment".BRAIN RESEARCH 1589.1589(2014):105-111.
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