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Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment
Shao, Shuang1; Li, Man1; Du, Wei1; Shao, Feng1; Wang, Weiwen2
2014-11-17
Source PublicationBRAIN RESEARCH
ISSN0006-8993
SubtypeArticle
Volume1589Issue:1589Pages:105-111
AbstractAdolescence is a critical period for neurodevelopment. MK-801 treatment and social isolation are important animal models for various neurodevelopmental disorders. Dysfunctions in the central cholinergic system are involved in creating the cognitive deficits observed in neurological diseases. In the present study, we aimed to investigate whether the acetylcholinesterase inhibitor galanthamine could reverse pre-cognitive prepulse inhibition (PPI) deficits and spatial learning deficits of adult rats in the Morris water maze. We induced these effects using either adolescent MK-801 treatment or social isolation from postnatal day (PND) 38-51. Our results showed that both adolescent social isolation and MK-801 treatment impaired PPI in adult rats, but neither had an effect on spatial learning. Furthermore, galanthamine injections over 7 days significantly enhanced PPI of normal rats and improved PPI disruption induced by adolescent pharmacological and rearing interventions. The results suggest that acetylcholinesterase inhibitors, such as galanthamine, might have the potential to improve pre-cognition in neurodevelopmental diseases by improving auditory sensory gating. (C) 2014 Elsevier B.V. All rights reserved.
KeywordAdolescence Mk-801 Social Isolation Galanthamine Prepulse Inhibition
Indexed BySCI
Language英语
WOS IDWOS:000345732600011
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14128
Collection中国科学院心理健康重点实验室
Affiliation1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Shao, Shuang,Li, Man,Du, Wei,et al. Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment[J]. BRAIN RESEARCH,2014,1589(1589):105-111.
APA Shao, Shuang,Li, Man,Du, Wei,Shao, Feng,&Wang, Weiwen.(2014).Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment.BRAIN RESEARCH,1589(1589),105-111.
MLA Shao, Shuang,et al."Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment".BRAIN RESEARCH 1589.1589(2014):105-111.
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