Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment

	Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment
	Shao, Shuang 1; Li, Man 1; Du, Wei 1; Shao, Feng 1; Wang, Weiwen2
摘要	Adolescence is a critical period for neurodevelopment. MK-801 treatment and social isolation are important animal models for various neurodevelopmental disorders. Dysfunctions in the central cholinergic system are involved in creating the cognitive deficits observed in neurological diseases. In the present study, we aimed to investigate whether the acetylcholinesterase inhibitor galanthamine could reverse pre-cognitive prepulse inhibition (PPI) deficits and spatial learning deficits of adult rats in the Morris water maze. We induced these effects using either adolescent MK-801 treatment or social isolation from postnatal day (PND) 38-51. Our results showed that both adolescent social isolation and MK-801 treatment impaired PPI in adult rats, but neither had an effect on spatial learning. Furthermore, galanthamine injections over 7 days significantly enhanced PPI of normal rats and improved PPI disruption induced by adolescent pharmacological and rearing interventions. The results suggest that acetylcholinesterase inhibitors, such as galanthamine, might have the potential to improve pre-cognition in neurodevelopmental diseases by improving auditory sensory gating. (C) 2014 Elsevier B.V. All rights reserved.
关键词	Adolescence Mk-801 Social Isolation Galanthamine Prepulse Inhibition
	2014-11-17
语种	英语
发表期刊	BRAIN RESEARCH
ISSN	0006-8993
卷号	1589 期号:1589 页码:105-111
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000345732600011
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/14128
专题	中国科学院心理健康重点实验室
作者单位	1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Shao, Shuang,Li, Man,Du, Wei,et al. Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment[J]. BRAIN RESEARCH,2014,1589(1589):105-111.
APA	Shao, Shuang,Li, Man,Du, Wei,Shao, Feng,&Wang, Weiwen.(2014).Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment.BRAIN RESEARCH,1589(1589),105-111.
MLA	Shao, Shuang,et al."Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment".BRAIN RESEARCH 1589.1589(2014):105-111.

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