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Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat
Luo Jia1,2; Wang Tao1; Liang Shan1,2; Hu Xu1; Li Wei1,2; Jin Feng1
2014-03-01
发表期刊SCIENCE CHINA-LIFE SCIENCES
ISSN1674-7305
文章类型Article
卷号57期号:3页码:327-335
摘要Evidence suggests that the hyperammonemia (HA)-induced neuroinflammation and alterations in the serotonin (5-HT) system may contribute to cognitive decline and anxiety disorder during hepatic encephalopathy (HE). Probiotics that maintain immune system homeostasis and regulate the 5-HT system may be potential treatment for HA-mediated neurological disorders in HE. In this study, we tested the efficacy of probiotic Lactobacillus helveticus strain NS8 in preventing cognitive decline and anxiety-like behavior in HA rats. Chronic HA was induced by intraperitoneal injection of ammonium acetate for four weeks in male Sprague-Dawley rats. HA rats were then given Lactobacillus helveticus strain NS8 (10(9) CFU mL(-1)) in drinking water as a daily supplementation. The Morris water maze task assessed cognitive function, and the elevated plus maze test evaluated anxiety-like behavior. Neuroinflammation was assessed by measuring the inflammatory markers: inducible nitric oxide synthase, prostaglandin E2, and interleukin-1 beta in the brain. 5-HT system activity was evaluated by measuring 5-HT and its metabolite, 5-HIAA, and the 5-HT precursor, tryptophan. Probiotic treatment of HA rats significantly reduced the level of inflammatory markers, decreased 5-HT metabolism, restored cognitive function and improved anxiety-like behavior. These results indicate that probiotic L. helveticus strain NS8 is beneficial for the treatment of cognitive decline and anxiety-like behavior in HA rats.
关键词hyperammonemia probiotics cognition anxiety neuroinflammation serotonin
收录类别SCI
语种英语
WOS记录号WOS:000332740100007
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/14129
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Luo Jia,Wang Tao,Liang Shan,et al. Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat[J]. SCIENCE CHINA-LIFE SCIENCES,2014,57(3):327-335.
APA Luo Jia,Wang Tao,Liang Shan,Hu Xu,Li Wei,&Jin Feng.(2014).Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat.SCIENCE CHINA-LIFE SCIENCES,57(3),327-335.
MLA Luo Jia,et al."Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat".SCIENCE CHINA-LIFE SCIENCES 57.3(2014):327-335.
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