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Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat
Luo Jia1,2; Wang Tao1; Liang Shan1,2; Hu Xu1; Li Wei1,2; Jin Feng1
2014-03-01
Source PublicationSCIENCE CHINA-LIFE SCIENCES
ISSN1674-7305
SubtypeArticle
Volume57Issue:3Pages:327-335
AbstractEvidence suggests that the hyperammonemia (HA)-induced neuroinflammation and alterations in the serotonin (5-HT) system may contribute to cognitive decline and anxiety disorder during hepatic encephalopathy (HE). Probiotics that maintain immune system homeostasis and regulate the 5-HT system may be potential treatment for HA-mediated neurological disorders in HE. In this study, we tested the efficacy of probiotic Lactobacillus helveticus strain NS8 in preventing cognitive decline and anxiety-like behavior in HA rats. Chronic HA was induced by intraperitoneal injection of ammonium acetate for four weeks in male Sprague-Dawley rats. HA rats were then given Lactobacillus helveticus strain NS8 (10(9) CFU mL(-1)) in drinking water as a daily supplementation. The Morris water maze task assessed cognitive function, and the elevated plus maze test evaluated anxiety-like behavior. Neuroinflammation was assessed by measuring the inflammatory markers: inducible nitric oxide synthase, prostaglandin E2, and interleukin-1 beta in the brain. 5-HT system activity was evaluated by measuring 5-HT and its metabolite, 5-HIAA, and the 5-HT precursor, tryptophan. Probiotic treatment of HA rats significantly reduced the level of inflammatory markers, decreased 5-HT metabolism, restored cognitive function and improved anxiety-like behavior. These results indicate that probiotic L. helveticus strain NS8 is beneficial for the treatment of cognitive decline and anxiety-like behavior in HA rats.
Keywordhyperammonemia probiotics cognition anxiety neuroinflammation serotonin
Indexed BySCI
Language英语
WOS IDWOS:000332740100007
Citation statistics
Cited Times:41[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14129
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Luo Jia,Wang Tao,Liang Shan,et al. Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat[J]. SCIENCE CHINA-LIFE SCIENCES,2014,57(3):327-335.
APA Luo Jia,Wang Tao,Liang Shan,Hu Xu,Li Wei,&Jin Feng.(2014).Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat.SCIENCE CHINA-LIFE SCIENCES,57(3),327-335.
MLA Luo Jia,et al."Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat".SCIENCE CHINA-LIFE SCIENCES 57.3(2014):327-335.
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