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| Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: A meta-analysis | |
Shi, Chuan1,2,3,4; Yu, Xin3,4; Cheung, Eric F. C.5; Shum, David H. K.6; Chan, Raymond C. K.1,2
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| 摘要 | This study sought to determine the moderators in the treatment effect of repetitive transcranial magnetic stimulation (rTMS) on negative symptoms in schizophrenia. We performed a meta-analysis of prospective studies on the therapeutic application of rTMS in schizophrenia assessing the effects of both low-frequency and high-frequency rTMS on negative symptoms. Results indicate that rTMS is effective in alleviating negative symptoms in schizophrenia. The effect size was moderate (0.63 and 0.53, respectively). The effect size of rTMS on negative symptoms in sham-controlled trials was 0.80 as measured by the SANS and 0.41 as measured by the PANSS. A longer duration of illness was associated with poorer efficacy of rTMS on negative symptoms. A 10 Hz setting, at least 3 consecutive weeks of treatment, treatment site at the left dorsolateral prefrontal cortex (DLPFC) and a 110% motor threshold (MT) were found to be the best rTMS parameters for the treatment of negative symptoms. The results of our meta-analysis suggest that rTMS is an effective treatment option for negative symptoms in schizophrenia. The moderators of rTMS on negative symptoms included duration of illness, stimulus frequency, duration of illness, position and intensity of treatment as well as the type of outcome measures used. (C) 2013 Elsevier Ireland Ltd. All rights reserved. |
| 关键词 | Negative symptoms Repetitive transcranial magnetic stimulation Schizophrenia Intervention Meta-analysis |
| 2014-03-30 | |
| 语种 | 英语 |
| 发表期刊 | PSYCHIATRY RESEARCH
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| ISSN | 0165-1781 |
| 卷号 | 215期号:3页码:505-513 |
| 期刊论文类型 | Review |
| 收录类别 | SSCI |
| WOS记录号 | WOS:000333776500002 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/14133 |
| 专题 | 中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China 4.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China 5.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 6.Griffith Univ, Griffith Hlth Inst, Behav Basis Hlth Res Program, Gold Coast, Australia |
| 第一作者单位 | 认知与发展心理学研究室 |
| 推荐引用方式 GB/T 7714 | Shi, Chuan,Yu, Xin,Cheung, Eric F. C.,et al. Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: A meta-analysis[J]. PSYCHIATRY RESEARCH,2014,215(3):505-513. |
| APA | Shi, Chuan,Yu, Xin,Cheung, Eric F. C.,Shum, David H. K.,&Chan, Raymond C. K..(2014).Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: A meta-analysis.PSYCHIATRY RESEARCH,215(3),505-513. |
| MLA | Shi, Chuan,et al."Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: A meta-analysis".PSYCHIATRY RESEARCH 215.3(2014):505-513. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| WOS_000333776500002.（1033KB） | 期刊论文 | 出版稿 | 暂不开放 | CC BY-NC-SA | 请求全文 | |
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