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Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: A meta-analysis
Shi, Chuan1,2,3,4; Yu, Xin3,4; Cheung, Eric F. C.5; Shum, David H. K.6; Chan, Raymond C. K.1,2
2014-03-30
Source PublicationPSYCHIATRY RESEARCH
ISSN0165-1781
SubtypeReview
Volume215Issue:3Pages:505-513
AbstractThis study sought to determine the moderators in the treatment effect of repetitive transcranial magnetic stimulation (rTMS) on negative symptoms in schizophrenia. We performed a meta-analysis of prospective studies on the therapeutic application of rTMS in schizophrenia assessing the effects of both low-frequency and high-frequency rTMS on negative symptoms. Results indicate that rTMS is effective in alleviating negative symptoms in schizophrenia. The effect size was moderate (0.63 and 0.53, respectively). The effect size of rTMS on negative symptoms in sham-controlled trials was 0.80 as measured by the SANS and 0.41 as measured by the PANSS. A longer duration of illness was associated with poorer efficacy of rTMS on negative symptoms. A 10 Hz setting, at least 3 consecutive weeks of treatment, treatment site at the left dorsolateral prefrontal cortex (DLPFC) and a 110% motor threshold (MT) were found to be the best rTMS parameters for the treatment of negative symptoms. The results of our meta-analysis suggest that rTMS is an effective treatment option for negative symptoms in schizophrenia. The moderators of rTMS on negative symptoms included duration of illness, stimulus frequency, duration of illness, position and intensity of treatment as well as the type of outcome measures used. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
KeywordNegative symptoms Repetitive transcranial magnetic stimulation Schizophrenia Intervention Meta-analysis
Indexed BySSCI
Language英语
WOS IDWOS:000333776500002
Citation statistics
Cited Times:60[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14133
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
4.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China
5.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
6.Griffith Univ, Griffith Hlth Inst, Behav Basis Hlth Res Program, Gold Coast, Australia
Recommended Citation
GB/T 7714
Shi, Chuan,Yu, Xin,Cheung, Eric F. C.,et al. Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: A meta-analysis[J]. PSYCHIATRY RESEARCH,2014,215(3):505-513.
APA Shi, Chuan,Yu, Xin,Cheung, Eric F. C.,Shum, David H. K.,&Chan, Raymond C. K..(2014).Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: A meta-analysis.PSYCHIATRY RESEARCH,215(3),505-513.
MLA Shi, Chuan,et al."Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: A meta-analysis".PSYCHIATRY RESEARCH 215.3(2014):505-513.
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