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Voxel-based morphometry study of the insular cortex in bipolar depression
Tang, Li-Rong1,2; Liu, Chun-Hong2,3; Jing, Bin4; Ma, Xin1,3; Li, Hai-Yun4; Zhang, Yu2; Li, Feng1,5; Wang, Yu-Ping6,7; Yang, Zhi8; Wang, Chuan-Yue3,5
2014-11-30
Source PublicationPSYCHIATRY RESEARCH-NEUROIMAGING
ISSN0925-4927
SubtypeArticle
Volume224Issue:2Pages:89-95
AbstractBipolar depression (BD) is a common psychiatric illness characterized by deficits in emotional and cognitive processing. Abnormalities in the subregions of the insula are common findings in neuroanatomical studies of patients with bipolar disorder. However, the specific relationships between morphometric changes in specific insular subregions and the pathogenesis of BD are not clear. In this study, structural magnetic resonance imaging (MRI) was used to investigate gray matter volume abnormalities in the insular subregion in 27 patients with BD and in 27 age and sex-matched controls. Using DARTEL (diffeomorphic anatomical registration through exponentiated lie algebra) for voxel-based morphometry (VBM), we examined changes in regional gray matter volumes of the insula in patients with BD. As compared with healthy controls, the BD patients showed decreased gray matter volumes in the right posterior insula and left ventral anterior insula and increased gray matter volumes in the left dorsal anterior insula. Consistent with the emerging theory of insular interference as a contributor to emotional-cognitive dysregulation, the current findings suggest that the insular cortex may be involved in the neural substrates of BD. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
KeywordBipolar Depression Magnetic Resonance Imaging Insula Voxel-based Morphometry
Indexed BySCI
Language英语
WOS IDWOS:000343826800003
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14134
Collection中国科学院行为科学重点实验室
Affiliation1.Capital Med Univ, Ctr Treatment Depress Disorders, Beijing 100088, Peoples R China
2.Capital Med Univ, Beijing Anding Hosp, Dept Radiol, Beijing 100088, Peoples R China
3.Capital Med Univ, Beijing Anding Hosp, Dept Psychiat, Beijing Key Lab Mental Disorders, Beijing 100088, Peoples R China
4.Capital Med Univ, Sch Biomed Engn, Beijing 100069, Peoples R China
5.Capital Med Univ, Minist Sci & Technol, Beijing Inst Brain Disorders, Ctr Schizophrenia,Lab Brain Disorders, Beijing 100088, Peoples R China
6.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China
7.Capital Med Univ, Beijing Key Lab Neuromodulat, Beijing 100053, Peoples R China
8.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Tang, Li-Rong,Liu, Chun-Hong,Jing, Bin,et al. Voxel-based morphometry study of the insular cortex in bipolar depression[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2014,224(2):89-95.
APA Tang, Li-Rong.,Liu, Chun-Hong.,Jing, Bin.,Ma, Xin.,Li, Hai-Yun.,...&Wang, Chuan-Yue.(2014).Voxel-based morphometry study of the insular cortex in bipolar depression.PSYCHIATRY RESEARCH-NEUROIMAGING,224(2),89-95.
MLA Tang, Li-Rong,et al."Voxel-based morphometry study of the insular cortex in bipolar depression".PSYCHIATRY RESEARCH-NEUROIMAGING 224.2(2014):89-95.
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