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Voxel-based morphometry study of the insular cortex in bipolar depression
Tang, Li-Rong1,2; Liu, Chun-Hong2,3; Jing, Bin4; Ma, Xin1,3; Li, Hai-Yun4; Zhang, Yu2; Li, Feng1,5; Wang, Yu-Ping6,7; Yang, Zhi8; Wang, Chuan-Yue3,5
2014-11-30
发表期刊PSYCHIATRY RESEARCH-NEUROIMAGING
ISSN0925-4927
文章类型Article
卷号224期号:2页码:89-95
摘要Bipolar depression (BD) is a common psychiatric illness characterized by deficits in emotional and cognitive processing. Abnormalities in the subregions of the insula are common findings in neuroanatomical studies of patients with bipolar disorder. However, the specific relationships between morphometric changes in specific insular subregions and the pathogenesis of BD are not clear. In this study, structural magnetic resonance imaging (MRI) was used to investigate gray matter volume abnormalities in the insular subregion in 27 patients with BD and in 27 age and sex-matched controls. Using DARTEL (diffeomorphic anatomical registration through exponentiated lie algebra) for voxel-based morphometry (VBM), we examined changes in regional gray matter volumes of the insula in patients with BD. As compared with healthy controls, the BD patients showed decreased gray matter volumes in the right posterior insula and left ventral anterior insula and increased gray matter volumes in the left dorsal anterior insula. Consistent with the emerging theory of insular interference as a contributor to emotional-cognitive dysregulation, the current findings suggest that the insular cortex may be involved in the neural substrates of BD. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
关键词Bipolar Depression Magnetic Resonance Imaging Insula Voxel-based Morphometry
收录类别SCI
语种英语
WOS记录号WOS:000343826800003
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/14134
专题中国科学院行为科学重点实验室
作者单位1.Capital Med Univ, Ctr Treatment Depress Disorders, Beijing 100088, Peoples R China
2.Capital Med Univ, Beijing Anding Hosp, Dept Radiol, Beijing 100088, Peoples R China
3.Capital Med Univ, Beijing Anding Hosp, Dept Psychiat, Beijing Key Lab Mental Disorders, Beijing 100088, Peoples R China
4.Capital Med Univ, Sch Biomed Engn, Beijing 100069, Peoples R China
5.Capital Med Univ, Minist Sci & Technol, Beijing Inst Brain Disorders, Ctr Schizophrenia,Lab Brain Disorders, Beijing 100088, Peoples R China
6.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China
7.Capital Med Univ, Beijing Key Lab Neuromodulat, Beijing 100053, Peoples R China
8.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
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Tang, Li-Rong,Liu, Chun-Hong,Jing, Bin,et al. Voxel-based morphometry study of the insular cortex in bipolar depression[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2014,224(2):89-95.
APA Tang, Li-Rong.,Liu, Chun-Hong.,Jing, Bin.,Ma, Xin.,Li, Hai-Yun.,...&Wang, Chuan-Yue.(2014).Voxel-based morphometry study of the insular cortex in bipolar depression.PSYCHIATRY RESEARCH-NEUROIMAGING,224(2),89-95.
MLA Tang, Li-Rong,et al."Voxel-based morphometry study of the insular cortex in bipolar depression".PSYCHIATRY RESEARCH-NEUROIMAGING 224.2(2014):89-95.
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